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Protective effects of D-Limonene against transient cerebral ischemia in stroke-prone spontaneously hypertensive rats.
Authors: Wang X, Li G, Shen W Abstract Stroke is a leading cause of disability and death world-wide and there is currently a lack of effective treatments for acute stroke. D-Limonene is a common natural monocyclic monoterpene possessing various activities. The present study aimed to evaluate the therapeutic efficacy of D-limonene against ischemia-associated cerebral injury in hypertensive SHRsp rats. Although systolic blood pressure was not altered by ischemia, D-Limonene decreased the systolic blood pressure of SHRsp rats following stroke. Induction of stroke resulted in increased escape latency time, decreased ti...
Source: Experimental and Therapeutic Medicine - February 6, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke.
Authors: KiliÇ E, ÇaĞlayan B, Caglar Beker M Abstract Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood circulation but particularly cerebrospinal fluid in a circadian manner. It can also easily diffuse through cellular membranes due its small size and lipophilic structure. Its cytoprotective activity has been linked to its potent free radical scavenger activity with the desirable characteristics of a clinically- reliable antioxidant. Melatonin deto...
Source: Turkish Journal of Medical Sciences - September 25, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Neuroprotective Effects of Grape Seed Procyanidin Extract on Ischemia-Reperfusion Brain Injury
Conclusion GSPE administration protects mice from ischemia-reperfusion brain injury through attenuating oxidative stress and apoptosis, promoting angiogenesis, and activating antioxidant enzyme GSH-Px. GSPE may represent a new therapeutical direction for the treatment of ischemia-reperfusion brain injury.
Source: Chinese Medical Sciences Journal - July 13, 2017 Category: General Medicine Source Type: research

Changes of complement and oxidative stress parameters in patients with acute cerebral infarction or cerebral hemorrhage and the clinical significance.
Authors: Zheng M, Wang X, Yang J, Ma S, Wei Y, Liu S Abstract Changes of complement and oxidative stress parameters in patients with acute cerebral infarction (ACI) or cerebral hemorrhage (CH), and their clinical significance were explored. A total of 122 patients with ACI or CH admitted to the People's Hospital of Zhangqiu Area from August 2018 to September 2019 were collected. There were 59 ACI patients assigned into a cerebral infarction group (CIG) and further 63 CH patients in a cerebral hemorrhage group (CHG). Additionally, 53 healthy people in physical examination during the same period were enrolled as a co...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Neuroprotective effects of an < em > in vitro < /em > BBB permeable phenoxythiophene sulfonamide small molecule in glutamate-induced oxidative injury
Exp Ther Med. 2022 Jan;23(1):79. doi: 10.3892/etm.2021.11002. Epub 2021 Nov 25.ABSTRACTReactive oxygen species (ROS) play a central role in oxidative stress-associated neuronal cell death during ischemia. Further investigation into the inhibition of excessive ROS generation post-stroke is urgently required for the treatment of ischemic stroke. In the present study, the neuroprotective properties of the blood-brain barrier (BBB) penetrant B355227 were investigated. B355227 is a chemical analogue of B355252, and the role of the phenoxythiophene sulfonamide compound B355227 was further investigated in a glutamate-induced oxid...
Source: Experimental and Therapeutic Medicine - December 23, 2021 Category: General Medicine Authors: Smritee Pokharel Nailya S Gliyazova Srinivasa R Dandepally Alfred L Williams Gordon C Ibeanu Source Type: research

Oxidation ‑reduction potential parameters worsen following intraarterial therapy in patients with reduced collateral circulation and middle cerebral artery occlusions
In conclusion, upon patient admission, the ORP parameters were not significantly different between the collateral circulation status groups for MCA occlusions. The ORP parameters worsened after IAT regardless of the collateral circulation status; however, after IAT, on day 2, patients with good collaterals experienced less oxidative stress (sORP) and had higher antioxidant reserves (cORP) than patients with reduced collaterals.PMID:37229324 | PMC:PMC10203750 | DOI:10.3892/etm.2023.11994
Source: Experimental and Therapeutic Medicine - May 25, 2023 Category: General Medicine Authors: Benjamin Atchie Stephanie Jarvis Richard Bellon Trevor Barton Lauren Disalvo Kristin Salottolo Raphael Bar-Or David Bar-Or Source Type: research

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