Filtered By:
Specialty: Neuroscience
Nutrition: Calcium

This page shows you your search results in order of date. This is page number 5.

Order by Relevance | Date

Total 118 results found since Jan 2013.

Molecular pathophysiological mechanisms of ischemia/reperfusion injuries after recanalization therapy for acute ischemic stroke
J Integr Neurosci. 2021 Sep 30;20(3):727-744. doi: 10.31083/j.jin2003078.ABSTRACTWith the larger variety of methods employed, recanalization therapy is increasingly used to treat acute ischemic stroke resulting in about one-third of patients undergoing early neurological deterioration, in which ischemia/reperfusion injuries are the main cause, leading to increases in the infarcted area, the no-reflow phenomenon, or hemorrhagic transformation. Efficient prevention or treatment of these injuries depends on extensive knowledge of the involved mechanisms. These pathways have dual, damaging, and neuroprotective effects, dependi...
Source: Journal of Integrative Neuroscience - October 14, 2021 Category: Neuroscience Authors: Anamaria Jurcau Ioana Adriana Ardelean Source Type: research

Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF- β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats
In conclusion, the study data supports the cerebroprotective role of efonidipine in diabetic animals possibly through TGF-β/SMAD-2 signaling pathway.
Source: Journal of Molecular Neuroscience - September 1, 2021 Category: Neuroscience Source Type: research

Down ‐regulation of miR‐3068‐3p enhances kcnip4‐regulated A‐type potassium current to protect against glutamate‐induced excitotoxicity
AbstractThe main cause of excitotoxic neuronal death in ischemic stroke is the massive release of glutamate. Recently, microRNAs (miRNAs) have been found to play an essential role in stroke pathology, although the molecular mechanisms remain to be investigated. Here, to identify potential candidate miRNAs involved in excitotoxicity, we treated rat primary cortical neurons with glutamate and found that miR ‐3068‐3p, a novel miRNA, was upregulated. We hypothesized that restoring miR‐3068‐3p expression might influence the neuronal injury outcomes. The inhibition of miR‐3068‐3p, using tough decoy lentiviruses, sign...
Source: Journal of Neurochemistry - December 1, 2019 Category: Neuroscience Authors: Zi ‐Jun Su, Xu‐Yi Wang, Chen Zhou, Zhen Chai Tags: ORIGINAL ARTICLE Source Type: research