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Impact of statin use on major adverse cardiovascular events in patients with normal stress myocardial perfusion imaging and elevated coronary artery calcium score
CONCLUSION: Post-MPI MHIS use is associated with lower MACE and is an independent negative predictor for 24-month MACE among patients with normal MPI and CAC > 300.PMID:35139626 | DOI:10.11622/smedj.2022018
Source: Singapore Medical Journal - February 10, 2022 Category: General Medicine Authors: Yi Hui To Xi Min Tan Cher-Lyn Low Htet Htet Min Min Sen Yew Source Type: research

Association between vascular calcification in intracranial vertebrobasilar circulation and luminal stenosis
ConclusionOur study showed a moderate correlation between higher burden of vascular calcification and the degree of luminal stenosis. However, higher calcium burden and circumferential wall calcification were not associated with severe luminal stenosis.
Source: Neuroradiology - May 12, 2022 Category: Radiology Source Type: research

Acetate suppresses myocardial contraction via the short-chain fatty acid receptor GPR43
The heart has high energy requirements, with an estimated 40%–60% of myocardial ATP production derived from the oxidation of fatty acids under physiological conditions. However, the effect of short-chain fatty acids on myocardial contraction remains controversial, warranting further research. The present study sought to investigate the effects and mechanisms of acetate, a short-chain fatty acid, on myocardial contraction in rat ventricular myocytes. Echocardiography and Langendorff heart perfusion were used to evaluate cardiac function. Cell shortening and calcium transient were measured in isolated cardiomyocytes. The p...
Source: Frontiers in Physiology - December 16, 2022 Category: Physiology Source Type: research

Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function
CONCLUSION: The TRPV1 at CV23 after EA treatment might play a key role in mediating local blood perfusion but was not involved in transferring EA signals to the central nervous system (CNS). These findings collectively suggested that TRPV1 may be one of the important regulators involved in the mechanism of EA treatment for improving swallowing function in PSD.PMID:37718934 | DOI:10.1111/cns.14457
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Si Yuan Bo Qiu Ying Liang Bing Deng Jing Xu Xiaorong Tang Junshang Wu Sheng Zhou Zeli Li Hongzhu Li Qiuping Ye Lin Wang Shuai Cui Chunzhi Tang Wei Yi Lulu Yao Nenggui Xu Source Type: research

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