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Specialty: Cardiology
Management: National Institutes of Health (NIH)
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Total 40 results found since Jan 2013.
Pulse pressure and in-hospital outcome of acute ischemic stroke
We aimed to evaluate the association between pulse pressure, a readily available marker of arterial stiffness, and the in-hospital outcome of patients with acute ischemic stroke. We prospectively studied 790 consecutive patients who were admitted with acute ischemic stroke (41.0% males, age 79.4±6.8 years). The severity of stroke was assessed at admission with the National Institutes of Health Stroke Scale (NIHSS). The outcome was assessed with dependency rates at discharge (modified Rankin scale between 2 and 5) and with in-hospital mortality.
Source: Journal of the American Society of Hypertension - March 31, 2016 Category: Cardiology Authors: Konstantinos Tziomalos, Stella Bouziana, Marianna Spanou, Stavroula Kostaki, Stella-Maria Angelopoulou, Maria Papadopoulou, Vasilios Giampatzis, Maria Tsopozidi, Christos Savopoulos, Apostolos I. Hatzitolios Tags: Stroke Source Type: research
Methods for stroke severity assessment by chart review in the Atherosclerosis Risk in Communities study
Sci Rep. 2022 Jul 19;12(1):12338. doi: 10.1038/s41598-022-16522-7.ABSTRACTStroke severity is the most important predictor of post-stroke outcome. Most longitudinal cohort studies do not include direct and validated measures of stroke severity, yet these indicators may provide valuable information about post-stroke outcomes, as well as risk factor associations. In the Atherosclerosis Risk in Communities (ARIC) study, stroke severity data were retrospectively collected, and this paper outlines the procedures used and shares them as a model for assessment of stroke severity in other large epidemiologic studies. Trained physic...
Source: Atherosclerosis - July 19, 2022 Category: Cardiology Authors: Silvia Koton Shalom Patole Julia M Carlson Taylor Haight Michelle Johansen Andrea L C Schneider James Russell Pike Rebecca F Gottesman Josef Coresh Source Type: research
Effects of Different Classes of Antihypertensive Agents on the Outcome of Acute Ischemic Stroke
It is unclear whether antihypertensive treatment before stroke affects acute ischemic stroke severity and outcome. To evaluate this association, the authors studied 482 consecutive patients (age 78.8±6.7 years) admitted with acute ischemic stroke. Stroke severity was assessed at admission with the National Institutes of Health Stroke Scale (NIHSS). The outcome was assessed with rates of adverse outcome (modified Rankin scale at discharge ≥2). Independent predictors of severe stroke (NIHSS ≥16) were female sex and atrial fibrillation. Treatment with diuretics before stroke was associated with nonsevere stroke. At disc...
Source: The Journal of Clinical Hypertension - March 1, 2015 Category: Cardiology Authors: Konstantinos Tziomalos, Vasilios Giampatzis, Stella D. Bouziana, Marianna Spanou, Maria Papadopoulou, Pavlina Kazantzidou, Stavroula Kostaki, Antonios Kouparanis, Christos Savopoulos, Apostolos I. Hatzitolios Tags: Original Paper Source Type: research
Predictive Role of hsCRP in Recurrent Stroke Differed According to Severity of Cerebrovascular Disease: Analysis from a Prospective Cohort Study
J Clin Med. 2023 Feb 20;12(4):1676. doi: 10.3390/jcm12041676.ABSTRACTElevated levels of high-sensitivity C-reactive protein (hsCRP) were associated with an increased risk of recurrent stroke. However, it is still unknown whether the predictive value of hsCRP differed according to the severity of cerebrovascular disease. We used the cohort of the prospective multicenter cohort study of the Third China National Stroke Registry (CNSR-III), in which 10,765 consecutive patients with acute ischemic stroke or transient ischemic attack (TIA) had hsCRP levels measured. Patients were classified into minor stroke, or TIA, and non-min...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Jiejie Li Yuesong Pan Mengxing Wang Xia Meng Jinxi Lin Zixiao Li Hao Li Yilong Wang Xingquan Zhao Liping Liu Yongjun Wang Source Type: research
Clinical significance of CT angiographic assessment of collateral circulation combined with serum NLRP1 levels in ischemic stroke patients
This study showed that the serum NLRP1 levels were remarkably decreased in ischemic stroke patients. In addition, the serum NLRP1 levels and ASITN/SIR grade could predict the prognosis of ischemic stroke patients.PMID:37000063 | DOI:10.1097/MD.0000000000033433
Source: Atherosclerosis - March 31, 2023 Category: Cardiology Authors: Chong Tao Yu Wang Shiyin Xiao Source Type: research
Factors Predicting Misidentification of Acute Ischemic Stroke and Large Vessel Occlusion by Paramedics
The emergence of thrombectomy for large vessel occlusions has increased the importance of accurate prehospital identification and triage of acute ischemic stroke (AIS). Despite available clinical scores, prehospital identification is suboptimal. Our objective was to improve the sensitivity of prehospital AIS identification by combining dispatch information with paramedic impression. We performed a retrospective cohort review of emergency medical services and hospital records of all patients for whom a stroke alert was activated in 1 urban, academic emergency department from January 1, 2018, to December 31, 2019. Using admi...
Source: Critical Pathways in Cardiology - November 24, 2022 Category: Cardiology Tags: Original Study Source Type: research
Effects of Batroxobin with Continuous Transcranial Doppler Monitoring in Patients with Acute Cerebral Stroke: A Randomized Controlled Trial
Our objective was to determine whether continuous transcranial Doppler (TCD) monitoring could safely enhance the efficacy of batroxobin, a thrombin‐like enzyme extracted from Bothrops atrox moojeni venom, in the treatment for acute cerebral stroke beyond the thrombolytic time window. Ninety patients suffering an acute cerebral stroke were recruited into the study within 12 hours after the onset of symptoms. Patients were randomized to receive batroxobin with (target group) or without 1 hour of continuous TCD monitoring (control group). Clinical evaluation of stroke was based on the National Institutes of Health Stroke ...
Source: Echocardiography - March 1, 2014 Category: Cardiology Authors: He Yitao, Ma Kefu, Tang Bingshan, Fu Xuejun, Zhan Ying, Cai Zhili, Jiang Xin, Yi Guo Tags: Original Investigation Source Type: research
Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury
Ann Clin Transl Neurol. 2023 Jun 23. doi: 10.1002/acn3.51837. Online ahead of print.ABSTRACTOBJECTIVE: Accumulating studies have shown that circulating circular RNAs (circRNAs) represent novel biomarkers for many human diseases. We investigated whether plasma circPTP4A2 and circTLK2 levels are associated with stroke severity, infarct volume, stroke etiology, and functional outcome in acute ischemic stroke (AIS) patients.METHODS: We applied quantitative real-time PCR (qPCR) to measure plasma circPTP4A2 and circTLK2 levels of 236 AIS patients within 72 h of symptoms onset and 136 healthy controls. We further assessed the Nat...
Source: Atherosclerosis - June 23, 2023 Category: Cardiology Authors: Xingzhi Wang Shenyang Zhang Zuohui Zhang Jie Zu Hongjuan Shi Lu Yu Bingchen Lv Likun Cui Wenqi Mao Di Wu Guiyun Cui Source Type: research
Prestroke treatment with beta-blockers for hypertension is not associated with severity and poor outcome in patients with ischemic stroke: data from a national stroke registry
Background: Beta-blockers are not recommended as the initial therapy for hypertension. Reports on associations between use of beta-blockers and stroke severity are inconclusive. We assessed associations between prestroke use of beta-blockers and stroke severity, poststroke disability and death in a large group of hypertensive patients hospitalized with acute ischemic stroke.
Methods: All 3915 patients with ischemic stroke, treated prestroke for hypertension and registered in the National Acute Stroke ISraeli, were included. Treatment for hypertension was classified by medication type (beta-blockers, diuretics, calcium ant...
Source: Journal of Hypertension - March 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Circular RNA FUNDC1 for Prediction of Acute Phase Outcome and Long-Term Survival of Acute Ischemic Stroke
This study aimed to explore the potential value of circRNAs for identifying acute neurological deterioration and estimating long-term survival for acute ischemic stroke (AIS). One hundred healthy controls and 200 patients with AIS within 72 h were recruited, 140 of whom were admitted within 24 h after onset. CircRNA levels in peripheral blood were measured by quantitative polymerase chain reaction (qPCR). Compared to the controls, the levels of three circRNAs were significantly increased in three subgroups of patients, including large artery atherosclerosis (LAA) stroke, small artery occlusion (SAO) stroke, and cardioembol...
Source: Atherosclerosis - June 20, 2022 Category: Cardiology Authors: Juan Zu Lei Zuo Lin Zhang Zan Wang Yachen Shi Lihua Gu Zhijun Zhang Source Type: research
Association of High Blood Homocysteine and Risk of Increased Severity of Ischemic Stroke Events
Int J Angiol DOI: 10.1055/s-0038-1667141Stroke is the leading cause of death and disability in the world as well as in Indonesia. Initial stroke severity is an important factor that affects short- and long-term stroke outcomes. This cross-sectional study was conducted in Cipto Mangunkusumo Hospital from July 2017 to January 2018 to investigate the factors that affect stroke severity. A total of 77 acute ischemic stroke patients were divided into three groups, which include low blood homocysteine levels (< 9 μmol/L), moderate blood homocysteine levels (9–15 μmol/L), and high blood homocysteine levels (> 15 μmol/L...
Source: International Journal of Angiology - July 26, 2018 Category: Cardiology Authors: Harris, Salim Rasyid, Al Kurniawan, Mohammad Mesiano, Taufik Hidayat, Rakhmad Tags: Original Article Source Type: research
Low levels of high-density lipoprotein cholesterol in patients with atherosclerotic stroke: A prospective cohort study
Abstract: Objective: The purpose of this study was to evaluate the influence of baseline high-density lipoprotein cholesterol (HDL-C) on initial stroke severity and clinical outcomes in acute ischemic stroke.Methods: From August 2006 through December 2011, patients with acute atherosclerotic ischemic stroke were included. Total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and HDL-C were checked and National Institutes of Health Stroke Scale (NIHSS) scores were obtained at admission. The primary outcomes were a composite end point of all-cause mortality, recurrent stroke, or occurrence of ischemic...
Source: Atherosclerosis - April 25, 2013 Category: Cardiology Authors: Poh-Shiow Yeh, Chun-Ming Yang, Sheng-Hsiang Lin, Wei-Ming Wang, Po-Sheng Chen, Ting-Hsing Chao, Huey-Juan Lin, Kao-Chang Lin, Chia-Yu Chang, Tain-Junn Cheng, Yi-Heng Li Tags: Epidemiology, Biomarkers, Nutrition Source Type: research
