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Optogenetic Stimulation Array for Confocal Microscopy Fast Transient Monitoring
Optogenetics is an emerging discipline with multiple applications in neuroscience, allowing to study neuronal pathways or serving for therapeutic applications such as in the treatment of anxiety disorder, autism spectrum disorders (ASDs), or Parkinson's disease. More recently optogenetics is opening its way also to stem cell-based therapeutic applications for neuronal regeneration after stroke or spinal cord injury. The results of optogenetic stimulation are usually evaluated by immunofluorescence or flow cytometry, and the observation of transient responses after stimulation, as in cardiac electrophysiology studies...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research

Hyper-acute EEG alterations predict functional and morphological outcomes in thrombolysis-treated ischemic stroke: a wireless EEG study
AbstractOwing to the large inter-subject variability, early post-stroke prognosis is challenging, and objective biomarkers that can provide further prognostic information are still needed. The relation between quantitative EEG parameters in pre-thrombolysis hyper-acute phase and outcomes has still to be investigated. Hence, possible correlations between early EEG biomarkers, measured on bedside wireless EEG, and short-term/long-term functional and morphological outcomes were investigated in thrombolysis-treated strokes. EEG with a wireless device was performed in 20 patients with hyper-acute (<  4.5 h from onset) ant...
Source: Medical and Biological Engineering and Computing - December 4, 2020 Category: Biomedical Engineering Source Type: research

A Multidimensional Data Acquisition as a Preliminary Step to the Secondary Prevention of the Loss of Autonomy for Patients With Traumatic Injury and Stroke: An AMISIA Pilot Study
Publication date: Available online 7 July 2020Source: IRBMAuthor(s): S. Mandigout, A. Perrochon, L. Fernandez, N. Rezzoug, B. Encelle, I. Kanellos, D. Ricard, M. Bouet, M. Shneider, S. Buffat
Source: IRBM - July 9, 2020 Category: Biomedical Engineering Source Type: research

A Fast Parallel Solver for the Forward Problem in Electrical Impedance Tomography
Electrical impedance tomography (EIT) is a noninvasive imaging modality, where imperceptible currents are applied to the skin and the resulting surface voltages are measured. It has the potential to distinguish between ischaemic and haemorrhagic stroke with a portable and inexpensive device. The image reconstruction relies on an accurate forward model of the experimental setup. Because of the relatively small signal in stroke EIT, the finite-element modeling requires meshes of more than 10 million elements. To study the requirements in the forward modeling in EIT and also to reduce the time for experimental image acquisiti...
Source: IEEE Transactions on Biomedical Engineering - December 19, 2014 Category: Biomedical Engineering Source Type: research

Dynamic Iterative Reconstruction for Interventional 4-D C-Arm CT Perfusion Imaging
We present a dynamic, iterative reconstruction (DIR) approach to reconstruct TACs described by a weighted sum of basis functions. To reduce noise, a regularization technique based on joint bilateral filtering (JBF) is introduced. We evaluated the algorithm with a digital dynamic brain phantom and with data from six canine stroke models. With our dynamic approach, we achieve an average Pearson correlation (PC) of the PCCT canine blood flow maps to co-registered perfusion CT maps of 0.73. This PC is just as high as the PC achieved in a recent PCCT study, which required repeated injections and acquisitions.
Source: IEE Transactions on Medical Imaging - June 28, 2013 Category: Biomedical Engineering Source Type: research