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The impact of lag time to cancer diagnosis and treatment on clinical outcomes prior to the COVID-19 pandemic: a scoping review of systematic reviews and meta-analyses
Conclusions: Our review highlighted measured associations between lag time and cancer-related outcomes and identified the need for a standardized methodological approach in areas such as lag time definitions and accounting for the waiting-time paradox. Prioritization of lag time research is integral for revised cancer care guidelines under pandemic contingency and assessing the pandemic's long-term effect on patients with cancer.Funding: The present work was supported by the Canadian Institutes of Health Research (CIHR-COVID-19 Rapid Research Funding opportunity, VR5-172666 grant to Eduardo L. Franco). Parker Tope, Eliya F...
Source: Cancer Control - January 31, 2023 Category: Cancer & Oncology Authors: Parker Tope Eliya Farah Rami Ali Mariam El-Zein Wilson H Miller Eduardo L Franco Source Type: research

Impact of the COVID-19-pandemic on patients with gynecological malignancies undergoing surgery: A Dutch population-based study using data from the 'Dutch Gynecological Oncology Audit'
CONCLUSIONS: The COVID-19-pandemic impacted surgical gynecological-oncology healthcare: in 2020, surgical volume for cervical cancer dropped considerably, waiting time was significantly shorter for all malignancies, while neoadjuvant chemotherapy administration for advanced-stage ovarian cancer increased. The safety of perioperative healthcare was not negatively impacted by the pandemic, as complications and 30-day-mortality remained stable.PMID:35221132 | DOI:10.1016/j.ygyno.2022.02.013
Source: Gynecologic Oncology - February 28, 2022 Category: Cancer & Oncology Authors: M D Algera W J van Driel B F M Slangen R F P M Kruitwagen M W J M Wouters participants of the Dutch Gynecological Oncology Collaborator group Source Type: research

Evaluating potential delays and outcomes of patients undergoing surgical resection for locally advanced and recurrent colorectal cancer during a pandemic
CONCLUSION: This study suggests that it is possible to mitigate the risks of COVID-19-related complications in patients undergoing complex surgery for locally advanced and recurrent CRC. Delay in surgical intervention is associated with tumour progression, particularly in patients who may not have neoadjuvant therapy. Efforts should be made to prioritise resources for patients requiring time-sensitive surgery for advanced and recurrent CRC.PMID:35132892 | DOI:10.1308/rcsann.2021.0274
Source: Annals of the Royal College of Surgeons of England - February 8, 2022 Category: Surgery Authors: M A Javed A Kohler J Tiernan A Quyn P Sagar Source Type: research

Neoadjuvant treatment with angiogenesis-inhibitor dovitinib prior to local therapy in hepatocellular carcinoma: a phase 2 study
CONCLUSION: Already after a short 4-week dovitinib treatment period, intratumoral blood flow reduction and modest antitumor responses were observed. Although these results support use of systemic neoadjuvant strategies, the poor tolerability indicates that dovitinib dose adaptations are required in HCC.IMPLICATIONS FOR PRACTICE: Orthotopic liver transplantation may cure early and intermediate stage hepatocellular carcinoma. Considering the expected waiting time >6 months due to donor liver scarcity, there is an unmet need for effective neoadjuvant downsizing strategies. Angiogenesis inhibition by dovitinib does not nega...
Source: The Oncologist - July 12, 2021 Category: Cancer & Oncology Authors: F J Sherida H Woei-A-Jin Nir I Weijl Mark C Burgmans Arantza Fari ña Sarasqueta J Tom van Wezel Martin N J M Wasser Minneke J Coenraad Jacobus Burggraaf Susanne Osanto Source Type: research

Analysis of the waiting time of the diagnosis for the first breast cancer treatment in southern Brazil
This study aimed to determine the waiting time from the diagnosis to the first breast cancer treatment at the University Hospital in southern Brazil to verify if the law #12,732/12 is being respected and to identify the impact of this waiting time on breast cancer progression. A retrospective, quantitative, and indirect approach was carried out by reviewing the medical records of 118 patients who underwent oncologic breast surgery at the University Hospital, an exclusive public service, from January 1st 2012 to December 31st 2016. Data analysis revealed that the average waiting time was 104.4 days and the median was 92.5 d...
Source: Women and Health - June 2, 2021 Category: Primary Care Authors: Francine Coutinho Maia de Castro Fl ávio Cabreira Jobim Luciane Flores Jacobi Source Type: research