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Infectious Disease: Parasitic Diseases
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Total 1019 results found since Jan 2013.
State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis
Curr Med Chem. 2023 Sep 15. doi: 10.2174/0929867331666230915093928. Online ahead of print.ABSTRACTProtozoan parasites represent a significant risk for public health worldwide, afflicting particularly people in more vulnerable categories and cause large morbidity and heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, route of administration, and cost, reflecting their low priority in global health management. Moreover, the drug resistance phenomenon threatens the positive therapy outcome. This scenario claims the need of addressing more adequate therapies. Among the diverse strategies impl...
Source: Current Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Valeria Francesconi Marco Rizzo Silvia Schenone Anna Carbone Michele Tonelli Source Type: research
Traditional uses, phytochemistry, pharmacology, and toxicology of the genus Artemisia L. (Asteraceae): A high-value medicinal plant
Curr Top Med Chem. 2023 Sep 14. doi: 10.2174/1568026623666230914104141. Online ahead of print.ABSTRACTBiologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal and aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, the genus Artemisia consists of approximately 500 species. Artemisia species have a rich history in traditional medicine worldwide, offering remedies for a wide range of ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, ...
Source: Current Topics in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Manzoor Hussain Rakesh Kr Thakur Jabeena Khazir Sajad Ahmed Mohammad Imtiyaj Khan Praveen Rahi Latif Ahmad Peer V S Pragadheesh Satwinderjeet Kaur S N Raina Zafar Ahmad Reshi Deepmala Sehgal Vijay Rani Rajpal Bilal Ahmad Mir Source Type: research
Three decades targeting falcipains to develop antiplasmodial agents: what have we learned and what can be done next?
Curr Med Chem. 2023 Sep 13. doi: 10.2174/0929867331666230913165219. Online ahead of print.ABSTRACTMalaria is a devastating infectious disease that affects large swathes of human populations across the planet's tropical regions. It is caused by parasites of the genus Plasmodium, with Plasmodium falciparum being responsible for the most lethal form of the disease. During the intraerythrocytic stage in the human hosts, malaria parasites multiply and degrade hemoglobin (Hb) using a battery of proteases, which include two cysteine proteases, falcipains 2 and 3 (FP-2 and FP-3). Due to their role as major hemoglobinases, FP-2 and...
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Jorge Enrique Hern ández González Emir Salas-Sarduy Lilian Hern ández Alvarez Pedro A Valiente Raghuvir K Arni Pedro G Pascutti Source Type: research
Design, synthesis and antiplasmodial evaluation of new amide-, carbamate-, and ureido-type harmicines
Bioorg Med Chem. 2023 Sep 7;94:117468. doi: 10.1016/j.bmc.2023.117468. Online ahead of print.ABSTRACTMalaria, one of the oldest parasitic diseases, remains a global health threat, and the increasing resistance of the malaria parasite to current antimalarials is forcing the discovery of new, effective drugs. Harmicines, hybrid compounds in which harmine/β-carboline alkaloids and cinnamic acid derivatives are linked via an amide bond or a triazole ring, represent new antiplasmodial agents. In this work, we used a multiple linear regression technique to build a linear quantitative structure-activity relationship (QSAR) model...
Source: Bioorganic and Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Marina Marinovi ć Hrvoje Rimac Lais Pessanha de Carvalho C R ôla S Santana Kristina Pavi ć Jana Held Miguel Prud êncio Zrinka Raji ć Source Type: research
Alkaline Ni-Zn Rechargeable Batteries for Sustainable Energy Storage: Battery Components, Deterioration Mechanisms, and Impact of Additives
ChemSusChem. 2023 Sep 8:e202300940. doi: 10.1002/cssc.202300940. Online ahead of print.ABSTRACTThe demand for long-term, sustainable, and low-cost battery energy storage systems with high power delivery capabilities for stationary grid-scale energy storage, as well as the necessity for safe lithium-ion battery alternatives, has renewed interest in aqueous zinc-based rechargeable batteries. The Alkaline Ni-Zn rechargeable battery chemistry was identified as a promising technology for sustainable energy storage applications, albeit a considerable investment in academic research, it still fails to deliver the requisite perfor...
Source: ChemSusChem - September 8, 2023 Category: Chemistry Authors: Katerina Bogomolov Yair Ein-Eli Source Type: research
Recent advances in fluorescence-based chemosensing of organoarsenic feed additives using luminescence MOFs, COFs, HOFs, and QDs
Chem Commun (Camb). 2023 Sep 7. doi: 10.1039/d3cc03125j. Online ahead of print.ABSTRACTOrganoarsenics are low-toxicity compounds that are used widely as feed additives to promote livestock growth, enhance meat pigmentation, and fight against intestinal parasites. The organoarsenic compounds are commonly found in poultry waste and the degradation of organoarsenic produces the toxic carcinogen inorganic arsenic such as As(V) and As(III), which results in severe arsenic pollution of soil and groundwater. As a consequence, there exists a high necessity to develop suitable sensing methods for the trace detection and quantificat...
Source: Chemical Communications - September 7, 2023 Category: Chemistry Authors: Rajdeep Mondal Ananthu Shanmughan A Murugeswari Sankarasekaran Shanmugaraju Source Type: research
