Filtered By:
Specialty: Molecular Biology
Infectious Disease: Parasitic Diseases
This page shows you your search results in order of date.
Order by Relevance | Date
Total 547 results found since Jan 2013.
Antimalarial drug discovery against malaria parasites through haplopine modification: An advanced computational approach
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17940. Online ahead of print.ABSTRACTThe widespread emergence of antimalarial drug resistance has created a major threat to public health. Malaria is a life-threatening infectious disease caused by Plasmodium spp., which includes Apicoplast DNA polymerase and Plasmodium falciparum cysteine protease falcipain-2. These components play a critical role in their life cycle and metabolic pathway, and are involved in the breakdown of erythrocyte hemoglobin in the host, making them promising targets for anti-malarial drug design. Our current study has been designed to explore the pote...
Source: Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Shopnil Akash Guendouzi Abdelkrim Imren Bayil Md Eram Hosen Nobendu Mukerjee Abdullah F Shater Fayez M Saleh Ghadeer M Albadrani Muath Q Al-Ghadi Mohamed M Abdel-Daim Tu ğba Taşkin Tok Source Type: research
Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants
Chem Biol Interact. 2023 Sep 16:110716. doi: 10.1016/j.cbi.2023.110716. Online ahead of print.ABSTRACTCongenital toxoplasmosis, caused by the opportunistic protozoan parasite T. gondii, can cause stillbirths, miscarriages and fetal abnormalities, as well as encephalitis and chorioretinitis in newborns. Available treatment options rely on antiparasitic drugs that have been linked to serious side effects, high toxicity and the development of drug-resistant parasites. The search for alternative therapeutics to treat this disease without acute toxicity for the mother and child is essential for the advancement of current therap...
Source: Chemico-Biological Interactions - September 18, 2023 Category: Molecular Biology Authors: Samuel Cota Teixeira Marina Paschoalino Guilherme de Souza Alessandra Monteiro Rosini Joed Pires de Lima Junior Luana Carvalho Luz Aryani Felixa Fajardo Mart ínez Rosiane Nascimento Alves Marcos Paulo Oliveira Almeida Jaqueline Lopes Damasceno Marcelo Jo Source Type: research
Schistosoma mansoni-induced oxidative stress triggers hepatocellular proliferation
CONCLUSIONS: Our data suggest that hepatocellular proliferation is triggered by S. mansoni egg-induced oxidative stress.PMID:37696392 | DOI:10.1016/j.jcmgh.2023.08.014
Source: Molecular Medicine - September 11, 2023 Category: Molecular Biology Authors: Verena von B ülow Maryam Schneider Dorothee Dreizler Lena Russ Anne Baier Nicola Buss Jakob Lichtenberger Lukas H ärle Heike M üller Annette Tschuschner Gabriele Schramm J örn Pons-Kühnemann Christoph G Grevelding Elke Roeb Martin Roderfeld Source Type: research
Avermectin B1a Shows Potential Anti-Proliferative and Anticancer Effects in HCT-116 Cells via Enhancing the Stability of Microtubules
This study aimed to investigate the potential anti-cancer activities of avermectin B1a using the HCT-116 colon cancer cell line. The MTT assay was used to calculate the IC50 by incubating cells with increasing doses of avermectin B1a for 24, 48, and 72 h. Flow cytometry was used to evaluate apoptosis following the 24 h incubation of cells. The migration capacity of the HCT-116 cells in the absence or presence of avermectin B1a was also investigated. Finally, tubulin polymerization in the presence of avermectin B1a was evaluated. Avermectin B1a presented anti-proliferative activity with an IC50 value of 30 μM. Avermectin B...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Qendresa Hoti Duygu Gencalp Rustem Ozlem Dalmizrak Source Type: research
