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Acute Fulminant Hepatic Failure Caused by Sevoflurane Linked to Influenza A
Exp Clin Transplant. 2023 Jun;21(6):540-542. doi: 10.6002/ect.2022.0386.ABSTRACTSevoflurane is a volatile anesthetic agent that does not tend to cause clinically significant hepatotoxicity, but there are some reported hepatotoxicity cases in the literature. In the case presented here, adenotonsillectomy was performed during influenza infection, and sevoflurane was administered, after which acute fulminant hepatitis developed. At hour 24 of hospitalization after fulminant hepatic failure, liver transplant was performed in a 3.5-year-old patient without any known diseases. In such cases, etiology investigations should be pla...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 17, 2023 Category: Transplant Surgery Authors: Alper Koker Gazi Arslan Ömer Özden Utku Karaarslan Tolga K öroğlu Source Type: research

Optimizing anesthesia and delivery approaches for dosing into lungs of mice
Am J Physiol Lung Cell Mol Physiol. 2023 Jul 4. doi: 10.1152/ajplung.00046.2023. Online ahead of print.ABSTRACTMicrobes, toxins, therapeutics and cells are often instilled into lungs of mice to model diseases and test experimental interventions. Consistent pulmonary delivery is critical for experimental power and reproducibility, but we observed variation in outcomes between handlers using different anesthetic approaches for intranasal dosing into mice. We therefore used a radiotracer to quantify lung delivery after intranasal dosing under inhalational (isoflurane) versus injectable (ketamine/xylazine) anesthesia in C57BL/...
Source: Am J Physiol Lung Ce... - July 4, 2023 Category: Respiratory Medicine Authors: Yurim Seo Longhui Qiu M élia Magnen Catharina Conrad S Farshid Moussavi-Harami Mark R Looney Simon J Cleary Source Type: research

Ferrets as Models for Viral Respiratory Disease
Comp Med. 2023 May 31. doi: 10.30802/AALAS-CM-22-000064. Online ahead of print.ABSTRACTDomestic ferrets (Mustela putorius furo) have been used in biomedical research to study influenza viruses since the early 20th century. Ferrets have continued to gain importance for the study of viral respiratory disease due to their disease susceptibility and anatomic similarities to humans. Here we review features of ferret biology and management that should be considered when planning to work with this species, particularly in models of respiratory disease. We specifically discuss biosafety and husbandry, clinical and pathologic asses...
Source: Comparative Medicine - May 31, 2023 Category: Zoology Authors: Rachel E Smith Shambhunath Choudhary Julita A Ramirez Source Type: research

Secondary infections in critically ill patients with viral pneumonia due to COVID-19 and influenza: a historical cohort study
CONCLUSION: Secondary infections were common among critically ill patients with viral pneumonia including COVID-19. We found no difference in the incidence of SI between COVID-19 and influenza in our cohort study, but SI in patients with COVID-19 were associated with worse clinical outcomes and increased healthcare resource use. The small cohort size precludes any causal inferences but may provide a basis for future research.PMID:36918454 | DOI:10.1007/s12630-022-02376-0
Source: Canadian Journal of Anaesthesia - March 15, 2023 Category: Anesthesiology Authors: Alina Beliavsky Barry Johnston Qixuan Li George Tomlinson Rupert Kaul John Granton Source Type: research

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