Filtered By:
Specialty: Chemistry
Infectious Disease: Tuberculosis
This page shows you your search results in order of date.
Order by Relevance | Date
Total 725 results found since Jan 2013.
Unraveling the unexpected aggregation behavior of Pyrazole-Based compounds Targeting Mycobacterium tuberculosis UDP-Galactopyranose mutase
Bioorg Med Chem. 2023 Sep 9;94:117466. doi: 10.1016/j.bmc.2023.117466. Online ahead of print.ABSTRACTA pyrazole-based compound, MS208, was previously identified as an inhibitor of UDP-Galactopyranose Mutase from Mycobacterium tuberculosis (MtUGM). Targeting this enzyme is a novel therapeutic strategy for the development of new antituberculosis agents because MtUGM is an essential enzyme for the bacterial cell wall synthesis and it is not present in human. It was proposed that MS208 targets an allosteric site in MtUGM as MS208 followed a mixed inhibition model. DA10, an MS208 analogue, showed competitive inhibition rather t...
Source: Bioorganic and Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Dalia M Ahmed David A R Sanders Source Type: research
Toward the early diagnosis of tuberculosis: A gold particle-decorated graphene-modified paper-based electrochemical biosensor for Hsp16.3 detection
Talanta. 2023 Sep 14;267:125210. doi: 10.1016/j.talanta.2023.125210. Online ahead of print.ABSTRACTTuberculosis (TB) currently remains a major life-threatening disease as it can be fatal if not treated properly or in a timely manner. Herein, we first describe a disposable and cost-effective paper-based electrochemical biosensor based on a gold particle-decorated carboxyl graphene (AuPs/GCOOH)-modified electrode for detecting heat shock protein (Hsp16.3), which is a specific biomarker indicating the onset of TB infection. The device pattern was first engineered to facilitate detection procedures and printed on low-cost filt...
Source: Talanta - September 17, 2023 Category: Chemistry Authors: Thimpika Pornprom Naruedon Phusi Paptawan Thongdee Bongkochawan Pakamwong Jidapa Sangswan Pharit Kamsri Auradee Punkvang Khomson Suttisintong Jiraporn Leanpolchareanchai Poonpilas Hongmanee Putthapoom Lumjiaktase Sakda Jampasa Orawon Chailapakul Pornpan P Source Type: research
Pyrrole-thiazolidinone hybrids as a new structural class of broad-spectrum anti-infectives
Eur J Med Chem. 2023 Aug 25;260:115757. doi: 10.1016/j.ejmech.2023.115757. Online ahead of print.ABSTRACTA series of pyrrole-thiazolidinone hybrids was designed, synthesized and evaluated for activities against ESKAP bacteria panel and mycobacterial pathogens. From the series, compound 9d showed prominent activity against S. aureus (MIC = 0.5 μg/mL) and compound 9k showed the most promising activity against M. tuberculosis H37Rv (MIC = 0.5 μg/mL). Potent derivatives were found to be non-toxic when tested against Vero cells. Compound 9d upon evaluation in vitro against several MRSA and VRSA strains produced activity compa...
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Shujauddin Ahmed Alka Mital Abdul Akhir Deepanshi Saxena Mohammad Naiyaz Ahmad Arunava Dasgupta Sidharth Chopra Rahul Jain Source Type: research
Orchids of Dibru-Saikhowa: A Systematic Review on Their Traditional Use, Pharmacological Activity and Phytochemistry
CONCLUSION: Orchids found in DSNPBR hold great significance in traditional culture for their medicinal properties and have been effectively studied for their bioactivities. Nevertheless, to confirm their effectiveness as therapeutics, conducting methodical research, examining their molecular mechanisms, and performing toxicity tests are necessary.PMID:37649298 | DOI:10.2174/1568026623666230830125205
Source: Current Topics in Medicinal Chemistry - August 31, 2023 Category: Chemistry Authors: Pal Gogoi Saikat Sen Source Type: research
Amino Acid Profiling as A Screening and Prognostic Biomarker in Active Tuberculosis Patients
CONCLUSIONS: Taken together, amino acid profiling can be used for TB screening, and a multiparameter profiling model is better. The profiling can also reflect the severity of lung damage. Moreover, the amino acid profile is useful for reflecting the efficacy of TB treatment.PMID:37625512 | DOI:10.1016/j.cca.2023.117523
Source: International Journal of Clinical Chemistry - August 25, 2023 Category: Chemistry Authors: Yunmei Sun Yunli Liao Nating Xiong Xing He Huihua Zhang Xiaomin Chen Guohui Xiao Zhaoqin Wang Weiqiao Rao Guoliang Zhang Source Type: research
