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Severity of COVID-19 in pregnant women: a review on the potential role of regulatory T cells
Curr Med Chem. 2023 Jun 19. doi: 10.2174/0929867330666230619114508. Online ahead of print.ABSTRACTAs a physiological condition, pregnancy may cause temporary alterations in the hematological, cardiopulmonary, and immune responses, affecting the maternal susceptibility to viral infections. Pregnant women are vulnerable to infection with the influenza A virus, hepatitis E virus, MERS CoV, and SARS CoV. The agent of Coronavirus disease (COVID-19) is the SARS coronavirus (SARS CoV-2), which affects the cells upon binding to the angiotensin-converting enzyme-2 (ACE2). However, ACE2 expression is elevated in the placental tissue...
Source: Current Medicinal Chemistry - June 21, 2023 Category: Chemistry Authors: Nafiseh Saghafi Mahmoud Mahmoudi Amir Abbas Momtazi-Borojeni Sara Mirzaeian Fataneh Tavasolian Thozhukat Sathyapalan Elham Abdollahi Amirhossein Sahebkar Source Type: research

Case report: Acute liver failure in children and the human herpes virus 6-? A factor in the recent epidemic
We report on the historic cases of three female infants who had suspected primary HHV-6B infection, acute hepatitis and rapid progression to acute liver failure (ALF) requiring LT. Appearances of their native liver were identical to those described in children in the recent hepatitis epidemic. Deteriorating clinical trajectories of recurrent graft hepatitis and rejection-like episodes followed and all three succumbed to graft failure with HHV-6B detected posthumously in their liver allografts. Our case series and the serious complications observed with the recent rise in common childhood infections is a reminder that these...
Source: Herpes - May 14, 2023 Category: Infectious Diseases Authors: Suz Warner Rachel M Brown Gary M Reynolds Zania Stamataki Deirdre A Kelly Source Type: research

Impact of Donation After Circulatory Death Allografts on Outcomes Following Simultaneous Liver-Kidney Transplant: A Single-Center Experience and Review of the Literature
CONCLUSIONS: Grafts from donors after circulatory death could help safely expand the donor pool in patients undergoing simultaneous liver-kidney transplant without compromising outcomes.PMID:37154590 | DOI:10.6002/ect.2023.0035
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 8, 2023 Category: Transplant Surgery Authors: Shiva Kumar Rachel Pedersen Ajay Sahajpal Source Type: research

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