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Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Design and Functional Evaluation of a Quasi-Passive Compliant Stance Control Knee–Ankle–Foot Orthosis
In this paper, we present the mechanical design, control algorithm, and functional evaluation of a quasi-passive compliant stance control knee–ankle–foot orthosis. The orthosis implements a spring in parallel with the knee joint during the stance phase of the gait and allows free rotation during the swing phase. The design is inspired by the moment-angle analysis of the knee joint revealing that the knee function approximates that of a linear torsional spring in the stance phase of the gait. Our orthosis aims to restore the natural function of a knee that is impaired by injury, stroke, post-polio, multiple sc...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - March 1, 2014 Category: Neuroscience Source Type: research