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Total 454 results found since Jan 2013.
Targeted drug delivery in pulmonary therapy based on adhesion and transmission of nanocarriers designed with a metal-organic framework
This study aimed to design a magnetic field-assisted targeted drug delivery system to the lungs using three types of metal-organic frameworks (MOFs) and nanoliposomes. The optimization of the system was based on three main parameters: the surface density of the nanocarriers' (NCs) adherence to each of the lung branches, the amount of drug transferred to each branch, and the toxicity based on the rate of nanocarrier delivery to the branches. The study investigated the effect of increasing the diameter of the drug carriers and the amount of drug loaded onto the NCs in improving drug delivery to targeted areas of the lung. Re...
Source: Biomechanics and Modeling in Mechanobiology - August 25, 2023 Category: Biomedical Science Authors: Hamed Ranjbar Amirhamzeh Farajollahi Mohsen Rostami Source Type: research
New cyclic arylguanidine scaffolds as a platform for development of antimicrobial and antiviral agents
Bioorg Chem. 2023 Jul 11;139:106730. doi: 10.1016/j.bioorg.2023.106730. Online ahead of print.ABSTRACTAccording to WHO, infectious diseases are still a significant threat to public health. The combine effects of antibiotic resistance, immunopressure, and mutations within the bacterial and viral genomes necessitates the search for new molecules exhibiting antimicrobial and antiviral activities. Such molecules often contain cyclic guanidine moiety. As part of this work, we investigated the selected antimicrobial and antiviral activity of compounds from the cyclic arylguanidine group. Molecules were designed using molecular m...
Source: Bioorganic Chemistry - July 20, 2023 Category: Chemistry Authors: Przemys ław Zaręba Anna K Drabczyk Sylwia Wnorowska Artur Wnorowski Jolanta Ja śkowska Source Type: research
Public perception of COVID-19 vaccines through analysis of Twitter content and users
This study successfully explores sentiment, emotion, topics, and user demographics to elucidate important trends in public perception about COVID-19 vaccines. While public perception trended positively over the study period, some trends, especially within certain topic and demographic clusters, are concerning for COVID-19 vaccine hesitancy. These insights can provide targets for educational interventions and opportunity for continued real-time monitoring.PMID:37385887 | PMC:PMC10288320 | DOI:10.1016/j.vaccine.2023.06.058
Source: Vaccine - June 29, 2023 Category: Allergy & Immunology Authors: Sameh N Saleh Samuel A McDonald Mujeeb A Basit Sanat Kumar Reuben J Arasaratnam Trish M Perl Christoph U Lehmann Richard J Medford Source Type: research
An electrochemical sensor based on Ce-MOF-derived Ce-doped poly(3,4-ethylenedioxythiophene) composite for efficient determination of rutin in food
Talanta. 2023 May 16;263:124678. doi: 10.1016/j.talanta.2023.124678. Online ahead of print.ABSTRACTAs a common antioxidant and nutritional fortifier in food chemistry, rutin has positive therapeutic effects against novel coronaviruses. Here, Ce-doped poly(3,4-ethylenedioxythiophene) (Ce-PEDOT) nanocomposites derived through cerium-based metal-organic framework (Ce-MOF) as a sacrificial template have been synthesized and successfully applied to electrochemical sensors. Due to the outstanding electrical conductivity of PEDOT and the high catalytic activity of Ce, the nanocomposites were used for the detection of rutin. The C...
Source: Talanta - May 29, 2023 Category: Chemistry Authors: Yilin Wang Jia Chen Chenxi Wang Li Zhang Yaqi Yang Chao Chen Yixi Xie Pengcheng Zhao Junjie Fei Source Type: research
Canine Olfactory Detection of SARS-CoV-2-Infected Humans - a Systematic Review
Ann Epidemiol. 2023 May 18:S1047-2797(23)00087-X. doi: 10.1016/j.annepidem.2023.05.002. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) developed into a pandemic within months. SARS-CoV-2 testing measures and vaccines became quickly accessible. However, due to pre- or asymptomatic transmission, effective disease control remains challenging. To complement conventional testing methods, scientists around the world have investigated dogs' olfactory capability for true real-time detection. Several diseases are known to produce specific scents in affected individuals, excreted as volatile organic compounds, whi...
Source: Annals of Epidemiology - May 20, 2023 Category: Epidemiology Authors: Sebastian Meller Charles Caraguel Friederike Twele Marios Charalambous Clara Schoneberg Anne-Lise Chaber Lo ïc Desquilbet Dominique Grandjean Fernando O Mardones Lothar Kreienbrock St éphane de la Rocque Holger A Volk Source Type: research
