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Specialty: Genetics & Stem Cells
Infectious Disease: SARS
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Total 605 results found since Jan 2013.
HPC-Atlas: Computationally Constructing A Comprehensive Atlas of Human Protein Complexes
Genomics Proteomics Bioinformatics. 2023 Sep 18:S1672-0229(23)00103-1. doi: 10.1016/j.gpb.2023.05.001. Online ahead of print.ABSTRACTA fundamental principle of biology is that proteins tend to form complexes to play significant roles in the core functions of cells. For a complete understanding of human cellular functions, it is crucial to have a comprehensive atlas of human protein complexes. Unfortunately, we still lack such a comprehensive atlas of experimentally validated protein complexes, which prevents us from gaining a complete understanding of the compositions and functions of human protein complexes and biological...
Source: Genomics Proteomics ... - September 20, 2023 Category: Genetics & Stem Cells Authors: Yuliang Pan Ruiyi Li Wengen Li Liuzhenghao Lv Jihong Guan Shuigeng Zhou Source Type: research
Alzheimer's Disease as A Viral Infectious Disease: Revisiting the Infectious Hypothesis
Ageing Res Rev. 2023 Sep 11:102068. doi: 10.1016/j.arr.2023.102068. Online ahead of print.ABSTRACTAlzheimer's disease (AD) represents the most frequent type of dementia in elderly people. Two major forms of the disease exist: sporadic - the causes of which have not yet been fully understood - and familial - inherited within families from generation to generation, with a clear autosomal dominant transmission of mutations in Presenilin 1 (PSEN1), 2 (PSEN2) or Amyloid Precursors Protein (APP) genes. The main hallmark of AD consists of extracellular deposits of amyloid-beta (Aβ) peptide and intracellular deposits of the hyper...
Source: Ageing Research Reviews - September 13, 2023 Category: Genetics & Stem Cells Authors: Francesco Bruno Paolo Abondio Rossella Bruno Leognano Ceraudo Ersilia Pararazzo Luigi Citrigno Donata Luiselli Amalia C Bruni Giuseppe Passarino Rosanna Colao Raffaele Maletta Alberto Montesanto Source Type: research
Correction: A Machine Learning Approach to Identify Potential miRNA-Gene Regulatory Network Contributing to the Pathogenesis of SARS-CoV-2 Infection
Biochem Genet. 2023 Sep 5. doi: 10.1007/s10528-023-10511-9. Online ahead of print.NO ABSTRACTPMID:37668831 | DOI:10.1007/s10528-023-10511-9
Source: Biochemical Genetics - September 5, 2023 Category: Genetics & Stem Cells Authors: Rajesh Das Vigneshwar Suriya Prakash Sinnarasan Dahrii Paul Amouda Venkatesan Source Type: research
Bioinformatics analysis of carotid vulnerable plaques associated with the SARS-CoV-2 Pattern
Gene. 2023 Aug 31:147754. doi: 10.1016/j.gene.2023.147754. Online ahead of print.ABSTRACTThe rupture of carotid artery vulnerable plaque plays a critical role in ischemic stroke, and the widely spread new coronavirus in recent years plays a certain role in the development of human carotid artery vulnerable plaque, we screened out 27 differential expression genes (DEGs) of stable plaque and vulnerable plaque associated with the new coronavirus. Through the construction of the protein-protein interaction (PPI) network, the Cathepsin B (CTSB) and Niemann-Pick Disease Type 2 (NPC2) were identified as crucial expression genes, ...
Source: Gene - September 2, 2023 Category: Genetics & Stem Cells Authors: Tao Jiang Jiaming Huang Shupeng Li Qiushi Xu Tianding Zhang Xianwei Wang Dong Chen Source Type: research
Viral Instant Mutation Viewer: A Tool to Speed Up the Identification and Analysis of New SARS-CoV-2 Emerging Variants and Beyond
Viruses. 2023 Jul 26;15(8):1628. doi: 10.3390/v15081628.ABSTRACTThe appearance of genetic variants impacts vaccination efficiency and therapeutic options, generating a need to map and relate mutations observed in the proteome and the genome. We develop an user-friendly web service software (Viral Instant Mutation Viewer or VIMVer) which allows a direct identification of mutations in the genome and its counterpart in the viral proteome. Since its emergence in 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has generated an overwhelming amount of data while becom...
Source: Genomics Proteomics ... - August 26, 2023 Category: Genetics & Stem Cells Authors: Vincent Wilde Bruno Canard Fran çois Ferron Source Type: research
Effect of the SARS-CoV-2 Delta-associated G15U mutation on the s2m element dimerization and its interactions with miR-1307-3p
RNA. 2023 Aug 21:rna.079627.123. doi: 10.1261/rna.079627.123. Online ahead of print.ABSTRACTThe stem loop 2 motif (s2m), a highly conserved 41-nucleotide hairpin structure in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome, serves as an attractive therapeutic target that may have important roles in the virus life cycle or interactions with the host. However, the conserved s2m in Delta SARS-CoV-2, a previously dominant variant characterized by high infectivity and disease severity, has received relatively less attention than that of the original SARS-CoV-2 virus. The focus of this work is to identify...
Source: RNA - August 21, 2023 Category: Genetics & Stem Cells Authors: Caylee L Cunningham Caleb J Frye Joseph A Makowski Adam H Kensinger Morgan Shine Ella J Milback Patrick E Lackey Jeffrey D Evanseck Mihaela Rita Mihailescu Source Type: research
The utility of SARS-CoV-2 genomic data for informative clustering under different epidemiological scenarios and sampling
CONCLUSION: Differences in epidemiology and sampling can impact our ability to identify genomic clusters that describe the underlying population structure. These findings can help to guide recommendations for the use of pathogen clustering in public health investigations.PMID:37531976 | DOI:10.1016/j.meegid.2023.105484
Source: Infection, Genetics and Evolution - August 2, 2023 Category: Genetics & Stem Cells Authors: Benjamin Sobkowiak Pouya Haghmaram Natalie Prystajecky James E A Zlosnik John Tyson Linda M N Hoang Caroline Colijn Source Type: research
A Machine Learning Approach to Identify Potential miRNA-Gene Regulatory Network Contributing to the Pathogenesis of SARS-CoV-2 Infection
This study attempts to perform the miRNA seq data analysis to identify the potential differentially expressed miRNAs. Considering only the experimentally proven interaction databases TarBase, miRTarBase, and miRecords, the target genes of the miRNAs have been identified from the mirNET analytics platform. The identified hub genes were subjected to gene ontology and pathway enrichment analysis using EnrichR. It is found that a total of 9 miRNAs are deregulated, out of which 2 were upregulated (hsa-mir-3614-5p and hsa-mir-3614-3p) and 7 were downregulated (hsa-mir-17-5p, hsa-mir-106a-5p, hsa-mir-17-3p, hsa-mir-181d-5p, hsa-m...
Source: Biochemical Genetics - July 29, 2023 Category: Genetics & Stem Cells Authors: Rajesh Das Vigneshwar Suriya Prakash Sinnarasan Dahrii Paul Amouda Venkatesan Source Type: research
Meta-analysis of Transcriptomic Data from Lung Autopsy and Cellular Models of SARS-CoV-2 Infection
Biochem Genet. 2023 Jul 24. doi: 10.1007/s10528-023-10453-2. Online ahead of print.ABSTRACTSevere COVID-19 is a systemic disorder involving excessive inflammatory response, metabolic dysfunction, multi-organ damage, and several clinical features. Here, we performed a transcriptome meta-analysis investigating genes and molecular mechanisms related to COVID-19 severity and outcomes. First, transcriptomic data of cellular models of SARS-CoV-2 infection were compiled to understand the first response to the infection. Then, transcriptomic data from lung autopsies of patients deceased due to COVID-19 were compiled to analyze alt...
Source: Biochemical Genetics - July 24, 2023 Category: Genetics & Stem Cells Authors: Nathan Araujo Cadore Vinicius Oliveira Lord Mariana Recamonde-Mendoza Thayne Woycinck Kowalski Fernanda Sales Luiz Vianna Source Type: research
