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Safety and Efficacy of MEDI0457 Plus Durvalumab in Patients With Human Papillomavirus-associated Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
CONCLUSIONS: MEDI0457 plus durvalumab was well tolerated. While the primary efficacy endpoint was not reached, clinical benefit was encouraging.PMID:36455147 | DOI:10.1158/1078-0432.CCR-22-1987
Source: Clinical Cancer Research - December 1, 2022 Category: Cancer & Oncology Authors: Charu Aggarwal Nabil F Saba Alain Algazi Ammar Sukari Tanguy Y Seiwert Missak Haigentz Mercedes Porosnicu Marcelo Bonomi Jean Boyer Mark T Esser Lily I Cheng Sonia Agrawal Emily C Jennings Nicholas M Durham Karl Fraser Delphine Lissa Maozhen Gong Natalia Source Type: research

An update on treatment of penile cancer
Ther Adv Med Oncol. 2022 Sep 24;14:17588359221127254. doi: 10.1177/17588359221127254. eCollection 2022.ABSTRACTPenile cancer is a rare malignancy, particularly in industrialized nations. In the United States, rates are approximately less than 1 per 100,000 men per year with just over 2000 new cases per year. However, there is significantly increased prevalence in developing nations, with limited treatment expertise and reduced access to care, further driving an unmet clinical need. The most noteworthy risk factor for penile cancer is the association with human papillomavirus infection, which may be present in up to 50% of ...
Source: Adv Data - September 29, 2022 Category: Epidemiology Authors: Juskaran Chadha Jad Chahoud Philippe E Spiess Source Type: research

Pretreatment C-Reactive Protein/Albumin Ratio is Associated With Poor Survival in Patients With 2018 FIGO Stage IB-IIA HPV-Positive Cervical Cancer
Conclusion: In patients with HPV-positive cervical cancer, depth of invasion, PNI and CAR are independent factors of OS, and depth of invasion, PLR and CAR are independent factors for PFS. For patients with HPV-negative disease, no inflammation indexes had predictive value for prognosis. The predictive value of inflammation indexes on prognosis is more significant in patients with HPV-positive cervical cancer. Stratification of HPV infection status promotes a more precise clinical application of inflammation indexes, thus improving their accuracy and feasibility.PMID:34992504 | PMC:PMC8724028 | DOI:10.3389/pore.2021.1609946
Source: Pathology Oncology Research - January 7, 2022 Category: Pathology Authors: Yinan Jiang Haifeng Gu Xiaojing Zheng Baoyue Pan Pingping Liu Min Zheng Source Type: research

Functional Organ Preservation Surgery in Head and Neck Cancer: Transoral Robotic Surgery and Beyond
Conclusions In the span of a very short time—less than a decade—robotic head and neck surgery has transformed the management of the head and neck cancer, and it seems clear that the future of treatment for these cancers lies in a multimodal approach in which TORS is likely to play an important role. Nevertheless, it is important to keep in mind that the current indications for TORS are limited and long-term data on the safety and oncological outcomes are needed to better understand the true role of TORS in treatment of head and neck cancer. Nonetheless, the emergence of ever more advanced robotic instrumen...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research