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Invasive mucorales sinusitis in a young patient with Emberger syndrome and newly diagnosed AML: A case report and literature review of invasive fungal infections in GATA2 deficiency
In this report, we present the case of a 40-year-old man with Emberger syndrome (GATA2 mutation, recently diagnosed acute myeloid leukaemia [AML] and history of lymphedema with hearing loss) who developed Mucorales sinusitis while receiving his first course of remission induction chemotherapy. Additionally, we review the literature on all published cases of proven IFIs in patients with GATA2 PVs. Clinicians should be aware that patients with GATA2 PVs could be vulnerable to opportunistic IFIs, even in the absence of AML and antineoplastic therapy. Furthermore, the distinctly unusual occurrence of mucormycosis during the fi...
Source: Cancer Control - August 7, 2023 Category: Cancer & Oncology Authors: Chia-Yu Chiu Takahiro Matsuo Sebastian Wurster Yoheved Gerstein Danielle E Hammond Kelly S Chien Courtney DiNardo Dimitrios P Kontoyiannis Source Type: research

Role of TNFSF15 variants in oral cancer development and clinicopathologic characteristics
In conclusion, although TNFSF15 SNVs did not affect OCSCC development, the patients with altered TNFSF15 SNVs exhibited poorer histological differentiation. The patients with higher TNFSF15 expression had poorer prognosis than did those with lower TNFSF15 expression.PMID:36226563 | DOI:10.1111/jcmm.17569
Source: Molecular Medicine - October 13, 2022 Category: Molecular Biology Authors: Hsueh-Ju Lu Chun-Yi Chuang Chun-Wen Su Mu-Kuan Chen Wei-En Yang Chia-Ming Yeh Chih-Hsin Tang Chiao-Wen Lin Shun-Fa Yang Source Type: research

Functional Organ Preservation Surgery in Head and Neck Cancer: Transoral Robotic Surgery and Beyond
Conclusions In the span of a very short time—less than a decade—robotic head and neck surgery has transformed the management of the head and neck cancer, and it seems clear that the future of treatment for these cancers lies in a multimodal approach in which TORS is likely to play an important role. Nevertheless, it is important to keep in mind that the current indications for TORS are limited and long-term data on the safety and oncological outcomes are needed to better understand the true role of TORS in treatment of head and neck cancer. Nonetheless, the emergence of ever more advanced robotic instrumen...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research