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Source: Journal of Chemical Neuroanatomy
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Total 19 results found since Jan 2013.
Effect of Nicorandil on the Spatial Arrangement of Primary Motor Cortical Neurons in the Sub-Acute Phase of Stroke in a Rat Model
Publication date: Available online 4 July 2021Source: Journal of Chemical NeuroanatomyAuthor(s): Maryam Owjfard, Zohreh Taghadosi, Mohammad Reza Bigdeli, Anahid Safari, Asadollah Zarifkar, Afshin Borhani-Haghighi, Mohammad Reza Namavar
Source: Journal of Chemical Neuroanatomy - July 5, 2021 Category: Neuroscience Source Type: research
TLR4 /NF-ĸB and JAK2/STAT3 signaling pathways: Cellular signaling pathways targeted by cell-conditioned medium therapy in protection against ischemic stroke
Publication date: Available online 23 February 2021Source: Journal of Chemical NeuroanatomyAuthor(s): Donya Nazarinia, Mojtaba Dolatshahi, Masoumeh Faezi, Solmaz Nasseri Maleki, Nahid Aboutaleb
Source: Journal of Chemical Neuroanatomy - February 25, 2021 Category: Neuroscience Source Type: research
Neuroprotective effects of human neural stem cells over-expressing choline acetyltransferase in a middle cerebral artery occlusion model
Publication date: January 2020Source: Journal of Chemical Neuroanatomy, Volume 103Author(s): Jihyun Kim, Kyungha Shin, Yeseul Cha, Young-Hwan Ban, Sung Kyeong Park, Heon Sang Jeong, Dongsun Park, Ehn-Kyoung Choi, Yun-Bae KimAbstractStroke is one of the most-devastating brain diseases causing acute death or permanent disability. Although tissue-type plasminogen activator was approved by Food and Drug Administration for early reperfusion of the occluded vessels, oxidative injury may cause extensive brain infarction. Accordingly, there is a need for effective neuroprotection during reperfusion, and stem cell-based therapeutic...
Source: Journal of Chemical Neuroanatomy - December 17, 2019 Category: Neuroscience Source Type: research
Conditioned medium obtained from human amniotic mesenchymal stem cells attenuates focal cerebral ischemia/ reperfusion injury in rats by targeting mTOR pathway
Publication date: Available online 28 October 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Donya Nazarinia, Nahid Aboutaleb, Raheleh Gholamzadeh, Solmaz Nasseri Maleki, Behnaz Mokhtari, Mahin NikougoftarAbstractConditioned medium obtained from human amniotic mesenchymal stem cells (hAMSC-CM) was recently shown to have many antioxidant, antiapoptotic and proangiogenic growth factors. The present study was performed to investigate whether protective effects of hAMSC-CM against focal cerebral ischemia/ reperfusion (I/R) injury is associated with modulation of the mammalian target of rapamycin (mTOR) pathway.A rat mo...
Source: Journal of Chemical Neuroanatomy - October 30, 2019 Category: Neuroscience Source Type: research
Phenotyping neurons activated in the mouse brain during restoration of salt debt
Publication date: Available online 6 August 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Craig M Smith, Joshua Cross, Izel M Eraslan, Aparna Attawar, Sarah Ch’ng, Poshmaal Dhar, Rasika Samarasinghe, Laura Gray, Andrew J LawrenceAbstractSalt overconsumption contributes to hypertension, which is a major risk factor for stroke, heart and kidney disease. Characterising neuronal pathways that may control salt consumption is therefore important for developing novel approaches for reducing salt overconsumption. Here, we identify neurons within the mouse central amygdala (CeA), lateral parabrachial nucleus (LPBN), inte...
Source: Journal of Chemical Neuroanatomy - August 7, 2019 Category: Neuroscience Source Type: research
Effect of G-CSF on the Spatial Arrangement of CA1 Hippocampal Pyramidal Neurons after Brain Ischemia in the male Rats
In conclusion, G-CSF had beneficial effects after cerebral ischemia on the neurological behavioral outcome, infarct volume and preserved the regular spatial distribution of CA1 hippocampal neurons.
Source: Journal of Chemical Neuroanatomy - April 19, 2019 Category: Neuroscience Source Type: research
Effects of Craniopharyngioma Cyst Fluid on Neurons and Glial Cells cultured from rat brain hypothalamus
In this study, we have collected CP cyst fluid (CCF) from mostly young patients during surgical removal and exposed it 9-10 days in vitro to the primary cultures derived from rat brain hypothalamus for 48 hours. A gradual decline in cell viability was noted with increasing concentration of CCF. Moreover, a distinct degenerative morphological transformation was observed in neurons and glial cells, including appearance of blebbing and overall reduction of the cell volume. Further, enhanced expression of Caspase-3 in neurons and glial cells exposed to CCF by immunofluorescence imaging, supported by Western blot experiment s...
Source: Journal of Chemical Neuroanatomy - October 17, 2018 Category: Neuroscience Source Type: research
Pluchea lanceolata protects hippocampal neurons from endothelin-1 induced ischemic injury to ameliorate cognitive deficits
Publication date: Available online 29 September 2018Source: Journal of Chemical NeuroanatomyAuthor(s): Ravi Mundugaru, Senthilkumar Sivanesan, Popa-Wagner A, Padmaja Udaykumar, Ramalingam Kirubagaran, Guruprasad KP, Vidyadhara D JAbstractIschemic brain injury is one of the leading causes of death and disability, where lack of disease modifying treatment strategies make us rely on symptomatic relief. Treatment principles from traditional systems of medicine may fill this gap and its validation in modern medicine perspective is important to bring them to mainstream. Here, we evaluated the neuroprotective efficacy of Ayurvedi...
Source: Journal of Chemical Neuroanatomy - October 4, 2018 Category: Neuroscience Source Type: research
The membrane mesenchymal stem cell derived conditioned medium exerts neuroprotection against focal cerebral ischemia by targeting apoptosis
ConclusionThe results of this study indicate that treatment with AMSC-CM improves the pathological effects in the acute phase of cerebral ischemia. These findings establish a substantial foundation for stroke therapy and future research.
Source: Journal of Chemical Neuroanatomy - August 17, 2018 Category: Neuroscience Source Type: research
Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in Bilateral Common Carotid Arterial occlusion (BCCAo) mouse model
This study shows a region-specific temporal molecular response to global ischemia in the brain, which is important to get better insight into the pathophysiology since each region consists of different subsets of neurons that are having different susceptibility and tolerance pattern/level. This insight into a temporally different ischemic response and the underlying molecular basis might help in strategizing the effective therapeutics against stroke.Graphical abstract
Source: Journal of Chemical Neuroanatomy - July 10, 2018 Category: Neuroscience Source Type: research
Mitochondrial SIRT3 and neurodegenerative brain disorders
Publication date: Available online 9 November 2017Source: Journal of Chemical NeuroanatomyAuthor(s): Anamika, Archita Khanna, Papia Acharjee, Arup Acharjee, Surendra Kumar TrigunAbstractSirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require NAD+ for their activity, the cellular level of Sirtuins represents redox status of the cells and thereby serves as bona fide metabolic stress sensors. Out of seven homologues of Sirtuins identified in mammals, SIRT3, 4 & 5 have been found to be localized and acti...
Source: Journal of Chemical Neuroanatomy - July 10, 2018 Category: Neuroscience Source Type: research
Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in Bilateral Common Carotid Arterial occlusion (BCCAo) mouse model
This study shows a region-specific temporal molecular response to global ischemia in the brain, which is important to get better insight into the pathophysiology since each region consists of different subsets of neurons that are having different susceptibility and tolerance pattern/level. This insight into a temporally different ischemic response and the underlying molecular basis might help in strategizing the effective therapeutics against stroke.Graphical abstract
Source: Journal of Chemical Neuroanatomy - July 5, 2018 Category: Neuroscience Source Type: research
Mitochondrial SIRT3 and neurodegenerative brain disorders
Publication date: Available online 9 November 2017Source: Journal of Chemical NeuroanatomyAuthor(s): Anamika, Archita Khanna, Papia Acharjee, Arup Acharjee, Surendra Kumar TrigunAbstractSirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require NAD+ for their activity, the cellular level of Sirtuins represents redox status of the cells and thereby serves as bona fide metabolic stress sensors. Out of seven homologues of Sirtuins identified in mammals, SIRT3, 4 & 5 have been found to be localized and acti...
Source: Journal of Chemical Neuroanatomy - July 5, 2018 Category: Neuroscience Source Type: research
Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in Bilateral Common Carotid Arterial occlusion (BCCAo) mouse model
This study shows a region-specific temporal molecular response to global ischemia in the brain, which is important to get better insight into the pathophysiology since each region consists of different subsets of neurons that are having different susceptibility and tolerance pattern/level. This insight into a temporally different ischemic response and the underlying molecular basis might help in strategizing the effective therapeutics against stroke. Graphical abstract
Source: Journal of Chemical Neuroanatomy - April 25, 2018 Category: Neuroscience Source Type: research
Mitochondrial SIRT3 and neurodegenerative brain disorders
Publication date: Available online 9 November 2017 Source:Journal of Chemical Neuroanatomy Author(s): Anamika, Archita Khanna, Papia Acharjee, Arup Acharjee, Surendra Kumar Trigun Sirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require NAD+ for their activity, the cellular level of Sirtuins represents redox status of the cells and thereby serves as bona fide metabolic stress sensors. Out of seven homologues of Sirtuins identified in mammals, SIRT3, 4 & 5 have been found to be localized and a...
Source: Journal of Chemical Neuroanatomy - December 8, 2017 Category: Neuroscience Source Type: research
