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Source: Journal of Neurochemistry
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Total 123 results found since Jan 2013.
Cystatin C improves blood –brain barrier integrity after ischemic brain injury in mice
We report that Cystatin C reduces the permeability of the blood –brain barrier (BBB) by up‐regulating the expression of caveolin‐1 and occludin in ischemic brain injury. Enhancing the permeability of the BBB leads to increased MMP‐9 and the death of bEnd.3 cells, which can be counteracted by ameliorating the BBB disruption and might represent a new thera peutic strategy for cerebral ischemic injury. The diagram shows that pretreatment with cystatin C increases caveolin‐1 and occludin expression in ischemic brain injury (right side of diagram). Left side of the diagram: cerebral ischemia‐reperfusion‐induced in...
Source: Journal of Neurochemistry - December 1, 2019 Category: Neuroscience Authors: Bo Yang,
Junjie Xu,
Liuhui Chang,
Zhigang Miao,
Dara Heang,
Yuwei Pu,
Xun Zhou,
Lingwei Zhang,
Hong Xie Tags: Original Article Source Type: research
Biglycan Regulates Neuroinflammation by Promoting M1 Microglial Activation in Early Brain Injury after Experimental Subarachnoid Hemorrhage
AbstractNeuroinflammation can be caused by various factors in early brain injury (EBI) after subarachnoid hemorrhage (SAH) One of the most important features of this process is M1 microglial activation. In turn, the TLR4/NF ‐κB pathway plays an essential role in activating M1 phenotypic microglia. Biglycan (BGN), a small leucine‐rich proteoglycan, functions as an endogenous ligand of TLR4 and TLR2 in macrophages. However, the underlying mechanisms associated with microglial activation in stroke pathogenesis are po orly understood. Here, we aimed to identify the role of biglycan in neuroinflammation following SAH. In o...
Source: Journal of Neurochemistry - November 27, 2019 Category: Neuroscience Authors: Yuke Xie,
Jianhua Peng,
Jinwei Pang,
Kecheng Guo,
Lifang Zhang,
Shigang Yin,
Jian Zhou,
Long Gu,
Tianqi Tu,
Qiancheng Mu,
Yuyan Liao,
Xianhui Zhang,
Ligang Chen,
Yong Jiang Tags: ORIGINAL ARTICLE Source Type: research
Metabolic fingerprints discriminating severity of acute ischemia using in vivo high ‐field 1H magnetic resonance spectroscopy
AbstractDespite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high ‐field1H MR Spectroscopy (1H ‐MRS) neurochemical profile as a metabolic signature for acute ischemia severity in rodent brains.We modeled global ischemia with one ‐stage 4‐vessel‐occlusion (4VO) in rats. Vascular structures were assessed immediately by magnetic resonance angiography (MRA). The neurochemical responses in the bilateral cortex were measured 1h after stroke onset by...
Source: Journal of Neurochemistry - November 22, 2019 Category: Neuroscience Authors: Mario G Lepore,
Lara Buscemi,
Lorenz Hirt,
Hongxia Lei Tags: ORIGINAL ARTICLE Source Type: research
Cystatin C Improves Blood ‐Brain Barrier Integrity After Ischemic Brain Injury in Mice
AbstractCystatin C, a well ‐established biomarker of renal function, has been associated with a protective effect against stroke. However, the potential neuroprotective mechanism of cystatin C in ischemic brain injury remains unclear. Our study hypothesized that cystatin C can ameliorate blood‐brain barrier (BBB) disrupti on by upregulating caveolin‐1 expression, thereby improving neurological outcomes in cerebral ischemic injury. Western blotting, immunohistochemistry, immunofluorescence staining, and immunoprecipitation were performed to investigate target proteins. Evans Blue and gelatin zymography were used to ex...
Source: Journal of Neurochemistry - October 10, 2019 Category: Neuroscience Authors: Bo Yang,
Junjie Xu,
Liuhui Chang,
Zhigang Miao,
Dara Heang,
Yuwei Pu,
Xun Zhou,
Lingwei Zhang,
Hong Xie Tags: ORIGINAL ARTICLE Source Type: research
Prothymosin alpha and its mimetic hexapeptide improve delayed tissue plasminogen activator ‐induced brain damage following cerebral ischemia
Administration of tissue plasminogen activator (tPA) beyond 4.5 h increases the risk of cerebral hemorrhage. Here, tPA administration during reperfusion at 4.5 or 6 h after middle cerebral artery occlusion or photochemically induced thrombosis in mice caused brain damage with hemorrhage. Co‐administration of prothymosin α (ProTα) or its mimetic hexapeptide (P6Q) inhibited tPA‐induced such brain damage. Therefore, ProTα or P6Q co‐administration would be beneficial to inhibit tPA‐induced hemorrhagic mechanisms in ischemic stroke. AbstractTissue plasminogen activator (tPA) administration beyond 4.5 h of stroke ...
Source: Journal of Neurochemistry - October 9, 2019 Category: Neuroscience Authors: Sebok Kumar Halder,
Hayato Matsunaga,
Hiroshi Ueda Tags: Original Article Source Type: research
Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice
This study is the first to document functional significance of Nln in pathophysiology of stroke and provide evidence that Nln is an endogenous mechanism functioning to preserve the brain from ischemic injury.This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - September 4, 2019 Category: Neuroscience Authors: Srinidhi Jayaraman,
Abdullah Al Shoyaib,
Joanna Kocot,
Heidi Villalba,
Faisal F. Alamri,
Mamoon Rashid,
Naomi J. Wangler,
Ekram A. Chowdhury,
Nadezhda German,
Thiruma V. Arumugam,
Thomas J. Abbruscato,
Vardan T. Karamyan Tags: Original Article Source Type: research
Prothymosin alpha and its mimetic hexapeptide improve delayed tPA ‐induced brain damage following cerebral ischemia
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 26, 2019 Category: Neuroscience Authors: Sebok Kumar Halder,
Hayato Matsunaga,
Hiroshi Ueda Tags: Original Article Source Type: research
Post ‐ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia
This study shows that necroptosis in cerebral cortex can be detected after 72 h of the insult and seems to be elicited before 48 h of reperfusion. The type of necroptosis here observed seems to be Tumor Necrosis Factor Receptor 1 (TNFR ‐1) independent. Necroptotic response is less evident in the CA1 hippocampal area than in cerebral cortex. The treatment with salubrinal administered 1 and 24 h after the ischemia, decreased the necroptotic marker levels and reduced the areas of selective neuronal loss, supporting the presence of ischemic‐dependent necroptosis, and the notion that ER stress is involved in the necroptotic...
Source: Journal of Neurochemistry - June 4, 2019 Category: Neuroscience Authors: Enrique Font ‐Belmonte,
Irene F Ugidos,
María Santos‐Galdiano,
Paloma González‐Rodríguez,
Berta Anuncibay‐Soto,
Diego Pérez‐Rodríguez,
Jose Manuel Gonzalo‐Orden,
Arsenio Fernández‐López Tags: Original Article Source Type: research
Metabolic constraints of swelling ‐activated glutamate release in astrocytes and their implication for ischemic tissue damage
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - April 28, 2019 Category: Neuroscience Authors: Corinne S. Wilson,
Martin D. Bach,
Zahra Ashkavand,
Kenneth R. Norman,
Nina Martino,
Alejandro P. Adam,
Alexander A. Mongin Tags: Original Article Source Type: research
Issue Cover (February 2019)
This study suggests that the non ‐canonical mechanism of CREB activation is a conserved mechanism in protection from excitotoxic necrosis, a finding that may help define the specific mechanism of neuroprotection in brain ischemia.Image Content: The image depicts in red the expression of a constitutively active form of CRTC in the nematode ‘s head (anterior: left ; dorsal: up ; scale bar: 10 micron). Green fluorescence (merged) labels neurons subjected to excitotoxicity.Read the full article‘Non ‐canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of exictotoxic necosis’ by
K. G...
Source: Journal of Neurochemistry - February 18, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research
G protein ‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes
In this study, we also demonstrate that selective activation of GPER induced astrocyte apoptosis via the phospholipase C pathway and subsequent intracellular calcium rise, whereas in neurons, this effect was not observed. Taken together, this evidence supports a direct impact of GPER activity on the viability of astrocytes, which seems to be associated with the regulation of different signaling pathways in astrocytes and neurons.
Source: Journal of Neurochemistry - January 28, 2019 Category: Neuroscience Authors: Cl áudio Roque,
Julieta Mendes‐Oliveira,
Graça Baltazar Tags: Original Article Source Type: research
Issue Cover (January 2019)
Front cover:Heat shock protein B8(HSPB8) has been recently reported to confer neuroprotection against ischemia ‐reperfusion(I/R)‐induced cerebral injury in vivo and in vitro. To investigate the effect of HSPB8 against neurological injury in a rat model of cerebral I/R, recombinant lentivirus vector (pLV‐HSPB8) was constructed and delivered through i.c.v injection in rats.We found that HSPB8 overexpression strongly alleviated infarct volume, improved neurobehavioral outcomes and reduced brain edema in rat middle cerebral artery occlusion/reperfusion (MCAO/R) model. HSPB8 overexpression promoted autophagic flux. Enhanc...
Source: Journal of Neurochemistry - January 15, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research
Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 7, 2019 Category: Neuroscience Authors: Alberto Martire,
Catia Lambertucci,
Rita Pepponi,
Antonella Ferrante,
Nicholas Benati,
Michela Buccioni,
Diego Dal Ben,
Gabriella Marucci,
Karl ‐Norbert Klotz,
Rosaria Volpini,
Patrizia Popoli Tags: Original Article Source Type: research
Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 5, 2019 Category: Neuroscience Authors: Kamaldeep S. Dhami,
Matthew A. Churchward,
Glen. B. Baker,
Kathryn G. Todd Tags: Original Article Source Type: research
G protein ‐coupled estrogen receptor activates cell type specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - December 20, 2018 Category: Neuroscience Authors: C Roque,
J. Mendes ‐Oliveira,
G. Baltazar Tags: Original Article Source Type: research
