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Peroxisome proliferator-activated receptor γ Pro12 ala polymorphism and risk of cerebral stroke in type 2 diabetes mellitus egyptian patients
ConclusionA12 containing genotypes and A12 allele are not associated with IR, diabetes and risk of IS development, however, significant higher BMI were observed in A12 allele carriers in the studied patients with diabetes as well as those with IS.
Source: Journal of Diabetes and Metabolic Disorders - December 22, 2022 Category: Endocrinology Source Type: research

Potential mechanisms for poor glycaemic control in patients with type two diabetes and fear of hypoglycaemia
ConclusionA significant finding of this study highlighted the considerable and direct effect of fear of hypoglycaemia on poor glycaemic control among patients with T2D. However, only fear-related anxiety and avoidance —and not confidence in the ability to control low glucose levels—had an effect on poor glycaemic control.
Source: Journal of Diabetes and Metabolic Disorders - September 29, 2022 Category: Endocrinology Source Type: research

Rating the importance of outcomes from diabetes trials. A survey of patients ’ and doctors’ opinions
ConclusionThe current study suggest that patients and doctors weigh some diabetic outcomes used as part of composite endpoints in clinical diabetes trials differently. These findings call for more studies on patient reported outcomes and patient education for improved personal care.Highlights• We performed this study to assess how patients and practicing physicians rate the importance of outcomes commonly used in diabetes trials.• We found that patients and doctors rate the importance of some outcomes used in clinical diabetes trials differently.• These findings suggest that shared decision making is pivotal when tak...
Source: Journal of Diabetes and Metabolic Disorders - November 25, 2021 Category: Endocrinology Source Type: research

Prevalence and factors connected with chronic diseases in the elderly residents of Birjand: a community – based study in Birjand, South Khorasan Province, Iran
ConclusionThe findings demonstrated that hypertension, diabetes mellitus, and stroke are the three prevalent NCDs among elders in the area and warrant a specific focus on reducing the burden of diseases and aligning healthcare services to prepare the whole needs of this population.
Source: Journal of Diabetes and Metabolic Disorders - November 3, 2021 Category: Endocrinology Source Type: research

Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME): study design and protocol
ConclusionPCIME will enable us to assess the role of malnutrition in development of post stroke dementia. This study will help clinicians and researchers develop preventive measures to reduce the burden of stroke and dementia.
Source: Journal of Diabetes and Metabolic Disorders - July 13, 2021 Category: Endocrinology Source Type: research

Acute myocardial infarction: Circadian, daily, monthly and seasonal patterns of occurrence in diabetics
ConclusionThe present study of Iranian patients with diabetes revealed that AMI occurred more frequently during the winter compared to the other seasons. ARBs use was associated with an increased odd of the AMI occurrence in winter.
Source: Journal of Diabetes and Metabolic Disorders - May 20, 2021 Category: Endocrinology Source Type: research

Burden of non-communicable diseases in Iran: past, present, and future
AbstractIran, as an in-transition country, tackled communicable diseases and now is confronting emerging challenges of non-communicable diseases (NCDs) in the path to reach health for everyone at all ages by 2030. Across Iran, death-averting treatments of NCDs have been expanded recently which might cause a shift toward a greater share of years lived with disability (YLDs) compared to years of life lost (YLLs) in the disability-adjusted life years of NCDs. Since the management of disability differs from the reduction of mortality in terms of public health policies, depicting the current picture of the burden of NCDs is pri...
Source: Journal of Diabetes and Metabolic Disorders - October 27, 2020 Category: Endocrinology Source Type: research

Prevalence of cardiometabolic syndrome in HIV-infected persons: a systematic review
ConclusionsCMetS was a common problem among HIV infected persons. Several RFs can contribute to the development of CMetS with smoking and hypertension highly interrelated.PROSPERO-numberCRD42018107187.
Source: Journal of Diabetes and Metabolic Disorders - June 8, 2020 Category: Endocrinology Source Type: research

Prevention of myocardial infarction and stroke with PCSK9 inhibitors treatment: a metanalysis of recent randomized clinical trials
ConclusionsPCSK9 inhibitors reduce the incidence of myocardial infarction by 19% and stroke by 25%.
Source: Journal of Diabetes and Metabolic Disorders - May 31, 2020 Category: Endocrinology Source Type: research

Deep learning approach for diabetes prediction using PIMA Indian dataset
ConclusionThe outcome of the study confirms that DL provides the best results with the most promising extracted features. DL achieves the accuracy of 98.07% which can be used for further development of the automatic prognosis tool. The accuracy of the DL approach can further be enhanced by including the omics data for prediction of the onset of the disease.
Source: Journal of Diabetes and Metabolic Disorders - April 13, 2020 Category: Endocrinology Source Type: research

Prevalence of diabetic nephropathy among Chinese patients with type 2 diabetes mellitus and different categories of their estimated glomerular filtration rate based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in primary care in Hong Kong: a cross-sectional study
ConclusionsDiabetic nephropathy was common among Chinese patients with type 2 diabetes in primary care in Hong Kong. Early identification and control of the modifiable risk factors are of upmost importance in preventing the complication.
Source: Journal of Diabetes and Metabolic Disorders - November 14, 2019 Category: Endocrinology Source Type: research

Relationship between hemoglobin A1c and serum troponin in patients with diabetes and cardiovascular events
ConclusionsChronic hyperglycemia decreases glomerular filtration and consequently decreases troponin elimination and also by affecting the heart microcirculation it leads to microvascular damage and consequently to ischemia which contribute to troponin concentration elevation. Furthermore, correlation between hemoglobin A1c and troponin concentration manifests in their prognostic value for mortality.
Source: Journal of Diabetes and Metabolic Disorders - November 10, 2019 Category: Endocrinology Source Type: research

The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials
ConclusionsThis meta-analysis suggested the beneficial impacts of ALA supplementation in improving fasting glucose of patients diagnosed with stroke.
Source: Journal of Diabetes and Metabolic Disorders - July 28, 2019 Category: Endocrinology Source Type: research

Obesity paradox on the survival of elderly patients with diabetes: an AHAP-based study
ConclusionAlthough overweight and obesity significantly improved the risk of mortality in elderly patients with diabetes, central obesity is still considered as an important risk factor.
Source: Journal of Diabetes and Metabolic Disorders - June 1, 2018 Category: Endocrinology Source Type: research