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Deep brain stimulation for stroke: Current uses and future directions
Survivors of stroke often experience significant disability and impaired quality of life related to ongoing maladaptive responses and persistent neurologic deficits. Novel therapeutic options are urgently needed to augment current approaches. One way to promote recovery and ameliorate symptoms may be to electrically stimulate the surviving brain. Various forms of brain stimulation have been investigated for use in stroke, including deep brain stimulation (DBS).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 11, 2017 Category: Neurology Authors: Gavin J.B. Elias, Andrew A. Namasivayam, Andres M. Lozano Source Type: research

Response to ‘Cerebellum as a possible target for neuromodulation after stroke’
We appreciated Fran ça and colleagues' letter (‘Cerebellum as a possible target for neuromodulation after stroke’) in response to our systematic review on deep brain stimulation for stroke [1]. Their primary point – concerning the relevance of the cerebellum to post-stroke neuromodulation – is well taken, espe cially given the increasing recognition of the cerebellum as a critical hub in the widespread, distributed neuronal networks that subserve varied motor, cognitive, and emotional processes [2–4].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - August 24, 2018 Category: Neurology Authors: Gavin J.B. Elias, Andres M. Lozano Source Type: research

DBS in critical care conditions
The efficacy of Deep Brain Stimulation (DBS) is well established in the treatment of chronic neurological diseases such as Parkinson's disease and primary dystonia. Emerging indications include, refractory epilepsy, chronic cluster headache, major depression, obsessive compulsive disorder, disruptive behaviour and Gilles de la Tourette syndrome. Nevertheless in selected cases DBS may be a treatment option in acute neurological disease or sudden dramatic worsening of pre-existing diseases in emergency conditions such as status dystonicus (SD) and post-stroke conditions.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Rizzi, R. Cordella, G. Messina, C.E. Marras, G. Zorzi, D. Caldiroli, A. Franzini Source Type: research

Modulation of cortical motor evoked potential after stroke during electrical stimulation of the lateral cerebellar nucleus
Deep brain stimulation (DBS) targeting the dentato-thalamo-cortical (DTC) pathway at its origin in the lateral cerebellar nucleus (LCN) has been shown to enhance motor recovery in a rodent model of cortical ischemia. LCN DBS also yielded frequency specific changes in motor cortex excitability in the normal brain, indexed by motor evoked potential (MEP) amplitude.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 8, 2015 Category: Neurology Authors: Hyun-Joo Park, Havan Furmaga, Jessica Cooperrider, John T. Gale, Kenneth B. Baker, Andre G. Machado Source Type: research

Short Circuit in Deep Brain Stimulation for Parkinson's Disease Mimicking Stroke
To the Editor:
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - August 20, 2016 Category: Neurology Authors: Niels Allert, Marta Reyes Santana, Hans Karbe Source Type: research

Deep brain stimulation of midbrain locomotor circuits in the freely moving pig
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been studied as a therapeutic target in rodent models of stroke, parkinsonism, and spinal cord injury. Clinical DBS trials have targeted the closely related pedunculopontine nucleus in patients with Parkinson ’s disease as a therapy for gait dysfunction, with mixed reported outcomes. Recent studies suggest that optimizing the MLR target could improve its effectiveness.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 27, 2021 Category: Neurology Authors: Stephano J. Chang, Andrea J. Santamaria, Francisco J. Sanchez, Luz M. Villamil, Pedro Pinheiro Saraiva, Francisco Benavides, Yohjans Nunez-Gomez, Juan P. Solano, Ioan Opris, James D. Guest, Brian R. Noga Source Type: research

Acute head- and gaze deviation, facial asymmetry and anarthria mimicking stroke, caused by short circuit in deep brain stimulation
We report here the case of a patient with acute onset of head- and gaze deviation, anarthria, and facial asymmetry who received intravenous thrombolysis for suspected cerebral ischemia and was subsequently found to have a causal short circuit of a DBS electrode.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 5, 2022 Category: Neurology Authors: Nils Schr öter, Anna Hager, Alexander Rau, Horst Urbach, Volker A. Coenen, Michel Rijntjes Source Type: research