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Source: Stroke
Therapy: Stem Cell Therapy

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Total 28 results found since Jan 2013.

Stroke: Highlights of Selected Articles Stroke: Highlights of Selected Articles
Source: Stroke - June 26, 2016 Category: Neurology Tags: Stem Cells, Magnetic Resonance Imaging (MRI), Quality and Outcomes, Ischemic Stroke, Thrombosis Stroke: Highlights of Selected Articles Source Type: research

Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study Clinical Sciences
Conclusions— In this interim report, SB623 cells were safe and associated with improvement in clinical outcome end points at 12 months. Clinical Trial Registration— URL: https://www.clinicaltrials.gov. Unique identifier: NCT01287936.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Steinberg, G. K., Kondziolka, D., Wechsler, L. R., Lunsford, L. D., Coburn, M. L., Billigen, J. B., Kim, A. S., Johnson, J. N., Bates, D., King, B., Case, C., McGrogan, M., Yankee, E. W., Schwartz, N. E. Tags: Clinical Studies, Ischemia, Stem Cells, Transplantation, Treatment Clinical Sciences Source Type: research

Systematic Review and Meta-Analysis of Bone Marrow-Derived Mononuclear Cells in Animal Models of Ischemic Stroke Basic Sciences
Conclusions— BMMNCs demonstrate beneficial effects across histological and behavioral outcomes in animal ischemic stroke models. Although study quality has improved over time, considerable degree of heterogeneity calls for standardization in the conduct and reporting of experimentation.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Vahidy, F. S., Rahbar, M. H., Zhu, H., Rowan, P. J., Bambhroliya, A. B., Savitz, S. I. Tags: Cell Therapy, Stem Cells, Ischemic Stroke Basic Sciences Source Type: research

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke Basic Sciences
Conclusions— hBMSC transplantation is therapeutic in chronic stroke possibly by abrogating the inflammation-plagued secondary cell death.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Acosta, S. A., Tajiri, N., Hoover, J., Kaneko, Y., Borlongan, C. V. Tags: Animal models of human disease, Pathology of Stroke, Other Stroke Treatment - Surgical Basic Sciences Source Type: research

Stem Cell-Based Tissue Replacement After Stroke: Factual Necessity or Notorious Fiction? Topical Reviews
Source: Stroke - July 27, 2015 Category: Neurology Authors: Janowski, M., Wagner, D.-C., Boltze, J. Tags: Cerebrovascular disease/stroke, Cell biology/structural biology, Acute Cerebral Infarction, Neuroprotectors, Other Stroke Treatment - Medical Topical Reviews Source Type: research

Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade Basic Sciences
Conclusions— Our data demonstrate that the Nampt–NAD cascade may act as a centralizing switch in postischemic regeneration through controlling different sirtuins and therefore represent a promising therapeutic target for long-term recovery of ischemic stroke.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Zhao, Y., Guan, Y.-F., Zhou, X.-M., Li, G.-Q., Li, Z.-Y., Zhou, C.-C., Wang, P., Miao, C.-Y. Tags: Animal models of human disease, Brain Circulation and Metabolism Basic Sciences Source Type: research

Delayed Pituitary Adenylate Cyclase-Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization Basic Sciences
Conclusions— Our results demonstrated that immunomodulatory strategies capable of redirecting the microglial response toward a neuroprotective M2 phenotype in the late phase of brain ischemia could represent attractive options for stroke treatment in a new and unexploited therapeutical window.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Brifault, C., Gras, M., Liot, D., May, V., Vaudry, D., Wurtz, O. Tags: Embolic stroke Basic Sciences Source Type: research

Intravenous Autologous Bone Marrow Mononuclear Stem Cell Therapy for Ischemic Stroke: A Multicentric, Randomized Trial Clinical Sciences
Conclusions— With the methods used, results of this hitherto first randomized controlled trial indicate that intravenous infusion of BMSCs is safe, but there is no beneficial effect of treatment on stroke outcome. Clinical Trial Registration— URLs: http://ctri.nic.in/Clinicaltrials and http://www.clinicaltrials.gov. Unique identifiers: CTRI-ROVCTRI/2008/091/0004 and NCT0150177.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Prasad, K., Sharma, A., Garg, A., Mohanty, S., Bhatnagar, S., Johri, S., Singh, K. K., Nair, V., Sarkar, R. S., Gorthi, S. P., Hassan, K. M., Prabhakar, S., Marwaha, N., Khandelwal, N., Misra, U. K., Kalita, J., Nityanand, S., for InveST Study Group Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Stem Cells as an Emerging Paradigm in Stroke 3: Enhancing the Development of Clinical Trials Special Report
Source: Stroke - January 27, 2014 Category: Neurology Authors: Savitz, S. I., Cramer, S. C., Wechsler, L., on behalf of STEPS 3 Consortium, STEPS 3 Consortium:, Aronowski, Boltze, Borlongan, Case, Chase, Chopp, Carmichael, Cramer, Duncan, Finklestein, Fischkoff, Guzman, Hess, Huang, Hinson, Kautz, Kondziolka, Mays, M Tags: Other Ethics and Policy, Other Stroke Treatment - Medical Special Report Source Type: research

Vasculogenesis in Experimental Stroke After Human Cerebral Endothelial Cell Transplantation Basic Sciences
Conclusions— We found attenuation of behavioral and histological deficits coupled with robust vasculogenesis and neurogenesis in endothelial cell–transplanted stroke animals, suggesting that targeting vascular repair sets in motion a regenerative process in experimental stroke possibly via the VEGF pathway.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Ishikawa, H., Tajiri, N., Shinozuka, K., Vasconcellos, J., Kaneko, Y., Lee, H. J., Mimura, O., Dezawa, M., Kim, S. U., Borlongan, C. V. Tags: Animal models of human disease Basic Sciences Source Type: research

Intra-arterial Cell Transplantation Provides Timing-Dependent Cell Distribution and Functional Recovery After Stroke Clinical Sciences
Conclusions— Our results indicate that intra-arterial cell transplantation provides timing-dependent cell distribution and poststroke functional recovery via a combination of neuroprotection, reactive astrocyte enhancement, and angiogenesis.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Ishizaka, S., Horie, N., Satoh, K., Fukuda, Y., Nishida, N., Nagata, I. Tags: Animal models of human disease Clinical Sciences Source Type: research

Human Dental Pulp-Derived Stem Cells Protect Against Hypoxic-Ischemic Brain Injury in Neonatal Mice Brief Reports
Conclusions— SHED transplantation into the HI-injured brain resulted in remarkable neurological and pathophysiological recovery. Our findings indicate that paracrine factors derived from SHED support a neuroprotective microenvironment in the HI brain. SHED graft and SHED-conditioned medium may provide a novel neuroprotective therapy for HI.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Yamagata, M., Yamamoto, A., Kako, E., Kaneko, N., Matsubara, K., Sakai, K., Sawamoto, K., Ueda, M. Tags: Animal models of human disease, Apoptosis Brief Reports Source Type: research

Mesenchymal Stem Cells Prevent Hydrocephalus After Severe Intraventricular Hemorrhage Basic Sciences
Conclusions— Intraventricular transplantation of umbilical cord blood-derived mesenchymal stem cells significantly attenuated the posthemorrhagic hydrocephalus and brain injury after IVH. This neuroprotective mechanism appears to be mediated by the anti-inflammatory effects of these cells.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Ahn, S. Y., Chang, Y. S., Sung, D. K., Sung, S. I., Yoo, H. S., Lee, J. H., Oh, W. I., Park, W. S. Tags: Animal models of human disease, Acute Cerebral Hemorrhage, Other Stroke Treatment - Medical Basic Sciences Source Type: research