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Source: Atherosclerosis
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Total 436 results found since Jan 2013.
Triglyceride-lowering therapy for the prevention of cardiovascular events, stroke, and mortality in patients with diabetes: A meta-analysis of randomized controlled trials
Triglyceride (TG)-lowering therapy is efficient for the prevention of cardiovascular disease (CVD) in the general population; however, for diabetic individuals, it is more controversial. The purpose of this study was to pool the results from randomized controlled trials (RCTs) to clarify whether the lowering of TG is beneficial for the prevention of CVD events, stroke, and mortality in subjects with diabetes.
Source: Atherosclerosis - July 12, 2023 Category: Cardiology Authors: Xiu Hong Yang, Qian Ming Tu, Li Li, Yong Ping Guo, Nian Song Wang, Hui Min Jin Source Type: research
Ischemic stroke patients with carotid atherosclerosis show dysfunctional high-density lipoprotein particles
Background and Aims: Twenty percent of ischemic strokes are caused by atherosclerosis from the internal carotid artery. HDL plays a protective role against the development of atherosclerosis. We aimed to compare the composition and the function of the HDL from ischemic stroke patients with carotid atherosclerosis and from healthy controls.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: N. Puig, A. Sol é, A. Aguilera-Simón, E. Jiménez-Xarrié, P. Camps-Renom, J.L. Sanchez-Quesada, S. Benitez Source Type: research
Biliverdin reductase B is a plasma biomarker for intraplaque hemorrhage and a predictor of ischemic stroke in symptomatic carotid stenosis
Background and Aims: Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with plaque IPH. We explored the biomarker potential of plasma BLVRB through 1) its correlation with IPH in carotid plaques assessed by magnetic resonance imaging (MRI) and with recurrent ischemic stroke; and 2) its use for monitoring pharmacotherapy targeting IPH in a preclinical setting.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: M. Chemaly, D. Marlevi, M.-J. Iglesias, M. Lengquist, M. Kronqvist, D. Bos, D.H.K. Van Dam-Nolen, A. Van Der Kolk, J. Hendrikse, M. Kassem, L. Matic, J. Odeberg, M.R. De Vries, M.E. Kooi, U. Hedin Source Type: research
Prevalence and risk factors of intracranial and extracranial atherosclerotic stenosis in Chinese patients with acute minor stroke or transient ischemic attack
Background and Aims: To investigate differences in prevalence and risk factors between intracranial and extracranial atherosclerotic stenosis (ICAS and ECAS) in patients with acute minor stroke or transient ischemic attack (TIA).
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: X. Tian, B. Ip, S. Li, Y. Liu, K.L. Chan, Y. Liu, S. Huang, K. Ma, S.H. Ma, F. Fan, V. Ip, Y. Soo, A. Lau, H. Leung, V. Mok, T. Leung, X. Leng Source Type: research
Tangier disease in Israel; Complicated by mobile lipomatous mass on mitral valve and acute stroke
Background and Aims: Tangier disease (TD) is a rare genetic disease which causes very low or even deficient HDL in plasma and accumulation of cholesterol in different tissues throughout the body. The disease is related to early onset of atherosclerotic disease and other clinical sequelae, previous articles described increased incidence of stroke in tangier patients. Valvular involvement in Tangier's disease was never described before .
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: R. Durst, S. Shpitzen, M. Mowaswes, D. Schurr, E. Leitersdorf Source Type: research
Upstream high wall shear stress associated with artery-to-artery embolism and recurrent stroke in symptomatic intracranial atherosclerotic stenosis
Background and Aims: To investigate associations of local wall shear stress (WSS) with artery-to-artery embolism (AAE) and risk of stroke recurrence, in symptomatic intracranial atherosclerotic stenosis (sICAS).
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: S. Li, L. Lan, X. Tian, H. Liu, B. Ip, S.H. Ma, J. Abrigo, Y. Liu, Y. Liu, K. Ma, F. Fan, V. Ip, Y. Soo, A. Lau, H. Leung, V. Mok, T. Leung, X. Leng Source Type: research
Association of thyroid peroxidase antibody with the RNF213 p.R4810K variant in ischemic stroke/transient ischemic attack
RNF213 is a susceptibility gene for moyamoya disease and vasospastic angina, with a second hit considered necessary for their development. Elevated thyroid peroxidase antibody (TPO-Ab) levels have been observed in both diseases, suggesting a possible role of TPO-Ab as a second hit for developing RNF213-related vasculopathy. We investigated the association of TPO-Ab levels with RNF213-related ischemic stroke (IS)/transient ischemic attack (TIA), other than moyamoya disease.
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Takeshi Yoshimoto, Hiroyuki Ishiyama, Yorito Hattori, Kunihiro Nishimura, Yoko Okada, Hideaki Watanabe, Yasumasa Ohyagi, Yasuhisa Akaiwa, Tomoyuki Miyamoto, Michi Kawamoto, Masahiko Ichijo, Hiroyasu Inoue, Noriyuki Matsukawa, Toshiki Mizuno, Hirofumi Mats Source Type: research
Impact of polyvascular disease on clinical outcomes in patients undergoing coronary revascularization: An observation from the CREDO-Kyoto Registry Cohort-2
Abstract: Objective: Patients with coronary artery disease (CAD) often have prior stroke or concomitant extra-cardiac vascular disease (EVD) such as cerebral, aortic, or peripheral vascular disease. However, clinical outcomes after coronary revascularization in patients with polyvascular disease have not been fully elucidated.Methods: Among 15,263 patients undergoing first coronary revascularization enrolled in the CREDO-Kyoto registry Cohort-2 from January 2005 to December 2007, there were 1443 patients with prior stroke (stroke + CAD group), 974 patients with EVD (EVD + CAD group), 253 patients with both prior stroke...
Source: Atherosclerosis - April 29, 2013 Category: Cardiology Authors: Yuko Morikami, Masahiro Natsuaki, Takeshi Morimoto, Koh Ono, Yoshihisa Nakagawa, Yutaka Furukawa, Ryuzo Sakata, Masaki Aota, Yukikatsu Okada, Masahiko Onoe, Michio Kawasuji, Takaaki Koshiji, Hiroyuki Nakajima, Junichiro Nishizawa, Kazuo Yamanaka, Hiroyuki Tags: Intervention Source Type: research
The combination of Helicobacter pylori- and cytotoxin-associated gene-A seropositivity in relation to the risk of myocardial infarction in middle-aged Japanese: The Japan Public Health Center-based study
Conclusions: H. pylori infection was not significantly associated with risk of MI and stroke among middle-aged Japanese. However, CagA positivity tended to be associated with MI.Highlights:
Source: Atherosclerosis - August 20, 2013 Category: Cardiology Authors: Ai Ikeda, Hiroyasu Iso, Shizuka Sasazuki, Manami Inoue, Shoichiro Tsugane, for the JPHC Study Group Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research
Adiponectin and risk of vascular events in the Northern Manhattan Study
Conclusions: In NOMAS, low-moderate adiponectin was associated with a decreased risk of vascular events despite the fact that low adiponectin levels were associated with an elevated vascular risk profile. These counter-intuitive findings underscore the need for further research on adiponectin as a useful biomarker of vascular disease risk and mechanisms explaining the inconsistent observations in the literature.Highlights: ► Low-moderate adiponectin was associated with a decreased risk of vascular events. ► A dose-response relationship was not suggested. ► The association was independent of demographics and vascular ...
Source: Atherosclerosis - December 17, 2012 Category: Cardiology Authors: Hannah Gardener, Ronald Goldberg, Armando J. Mendez, Clinton B. Wright, Tatjana Rundek, Mitchell S.V. Elkind, Ralph L. Sacco Tags: Epidemiology, Biomarkers, Nutrition Source Type: research
Obstructive sleep apnea and cardiovascular risk: Meta-analysis of prospective cohort studies
Conclusions: In conclusion, findings from this meta-analysis supported that moderate-severe OSA significantly increased cardiovascular risk, in particular stroke risk.
Source: Atherosclerosis - May 16, 2013 Category: Cardiology Authors: Jia-Yi Dong, Yong-Hong Zhang, Li-Qiang Qin Tags: Reviews Source Type: research
Predictive value of ankle-brachial index and PAI-1 in symptomatic intracranial atherosclerotic disease recurrence
Abstract: Background and purpose: We prospectively examine the single and combined predictive value of biological and clinical markers in recurrent strokes related to intracranial atherosclerotic disease (ICAD).Methods: In 73 ICAD first-ever stroke patients, ankle-brachial index (ABI) was assessed three months after TIA or stroke together with CRP, Lp-PLA2, ICAM-1, E-selectin and PAI-1 measurements. Appearance of new TIA/stroke was assessed every 6 months.Results: After a median follow-up of 22.4 months, 13 patients (17.8%) suffered a new stroke or TIA. Risk of new cerebrovascular events (CVEs) was associated with lowered ...
Source: Atherosclerosis - February 18, 2014 Category: Cardiology Authors: A. Massot, D. Giralt, A. Penalba, T. Garcia-Berrocoso, M. Navarro-Sobrino, J.F. Arenillas, M. Ribó, C.A. Molina, J. Alvarez-Sabín, J. Montaner, P. Delgado Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research
Coronary and carotid atherosclerosis: Similarities and differences
Abstract: Although a relationship is commonly accepted between coronary and carotid arterial disease, suggesting that atherosclerosis is a systemic condition, the extent of this association and correspondence has not been fully elucidated. This review discusses recent research in this field and highlights areas for future study. The prevalence of severe carotid stenosis increases with prevalence of coronary stenosis, with the latter being found in a significant number of stroke patients, while those with carotid stenosis may be at higher risk of myocardial infarction than stroke. There also appear to be common risk factors...
Source: Atherosclerosis - December 7, 2012 Category: Cardiology Authors: Fisnik Jashari, Pranvera Ibrahimi, Rachel Nicoll, Gani Bajraktari, Per Wester, Michael Y. Henein Tags: Reviews Source Type: research
MicroRNA-616 and atherosclerosis – A commentary on the paper by Liu et al.
MicroRNAs (miRNA, miR) in cardiovascular diseases are a constantly growing field. As individual microRNAs are predicted to regulate the expression of hundreds of genes, and a single gene can be targeted by numerous microRNAs, microRNA profiling can rarely indicate the mechanism through which microRNAs affect the disease. In their paper “A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis”, Liu et al. have shown a decreased binding affinity of miR-616 to the 3′-UTR as well as an increased paraoxonase 1 (PON1) expression in a plasmid co...
Source: Atherosclerosis - March 6, 2013 Category: Cardiology Authors: Emma Raitoharju Tags: Invited Commentaries Source Type: research
