Filtered By:
Specialty: Genetics & Stem Cells
Source: Ageing Research Reviews

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 65 results found since Jan 2013.

Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis.
CONCLUSION AND RELEVANCE: Post stroke depression is associated with a significantly increased risk of mortality in stroke survivors. More researches are required on the association with stroke recurrence. PMID: 30711712 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - January 31, 2019 Category: Genetics & Stem Cells Authors: Cai W, Mueller C, Li YJ, Shen WD, Stewart R Tags: Ageing Res Rev Source Type: research

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke.
Abstract Stem cell-based treatments have been suggested as promising candidates for stroke. Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for a wide range of diseases. In particular, clinical trial studies have suggested MSCs for stroke therapy. The focus of MSC treatments has been directed towards cell replacement. However, recent research has lately highlighted their paracrine actions. The secretion of extracellular vesicles (EVs) is offered to be the main therapeutic mechanism of MSC therapy. However, EV-based treatments may provide a wider therapeutic window compared to t...
Source: Ageing Research Reviews - June 17, 2020 Category: Genetics & Stem Cells Authors: Rahmani A, Saleki K, Javanmehr N, Khodaparast J, Saadat P, Nouri HR Tags: Ageing Res Rev Source Type: research

Association of blood lipids, atherosclerosis and statin use with dementia and cognitive impairment after stroke: a systematic review and meta-analysis.
CONCLUSION: Atherosclerosis may be associated with an increased risk of post-stroke dementia. Post-stroke statin use was associated with decreased risk of cognitive impairment. To confirm whether or not statins confer advantages in the post-stroke population in terms of preventing cognitive decline over and above their known effectiveness in reducing risk of further vascular events, further stroke trials including cognitive assessment and observational analyses adjusted for key confounders, focusing on key subgroups or statin use patterns are required. PMID: 31505259 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - September 6, 2019 Category: Genetics & Stem Cells Authors: Yang Z, Wang H, Edwards D, Ding C, Yan L, Brayne C, Mant J Tags: Ageing Res Rev Source Type: research

Multi-omics research strategies in ischemic stroke: A multidimensional perspective
Ageing Res Rev. 2022 Sep 7:101730. doi: 10.1016/j.arr.2022.101730. Online ahead of print.ABSTRACTIschemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high rate of death and long-term impairment. Despite years of studies, there are still no stroke biomarkers for clinical practice, and the molecular mechanisms of stroke remain largely unclear. The high-throughput omics approach provides new avenues for discovering biomarkers of IS and explaining its pathological mechanisms. However, single-omics approaches only provide a limited understanding of the biological pathways of diseases. The integr...
Source: Ageing Research Reviews - September 10, 2022 Category: Genetics & Stem Cells Authors: Wentao Li Chongyu Shao Huifen Zhou Haixia Du Haiyang Chen Haitong Wan Yu He Source Type: research

Pathogenesis of Acute Stroke and the Role of Inflammasomes.
Abstract Inflammation is an innate immune response to infection or tissue damage that is designed to limit harm to the host, but contributes significantly to ischemic brain injury following stroke. The inflammatory response is initiated by the detection of acute damage via extracellular and intracellular pattern recognition receptors, which respond to conserved microbial structures, termed pathogen-associated molecular patterns or host-derived danger signals termed damage-associated molecular patterns. Multi-protein complexes known as inflammasomes (e.g. containing NLRP1, NLRP2, NLRP3, NLRP6, NLRP7, NLRP12, NLRC4,...
Source: Ageing Research Reviews - October 5, 2013 Category: Genetics & Stem Cells Authors: Fann DY, Lee SY, Manzanero S, Chunduri P, Sobey CG, Arumugam TV Tags: Ageing Res Rev Source Type: research

Stem cell therapies in age-related neurodegenerative diseases and stroke.
Abstract Aging, a complex process associated with various structural, functional and metabolic changes in the brain, is an important risk factor for neurodegenerative diseases and stroke. These diseases share similar neuropathological changes, such as the formation of misfolded proteins, oxidative stress, loss of neurons and synapses, dysfunction of the neurovascular unit (NVU), reduction of self-repair capacity, and motor and/or cognitive deficiencies. In addition to gray matter dysfunction, the plasticity and repair capacity of white matter also decrease with aging and contribute to neurodegenerative diseases. A...
Source: Ageing Research Reviews - November 18, 2016 Category: Genetics & Stem Cells Authors: Wang Y, Ji X, Leak RK, Chen F, Cao G Tags: Ageing Res Rev Source Type: research

Atrial fibrillation in the elderly: A risk factor beyond stroke.
Abstract Atrial fibrillation (AF) represents the most common arrhythmia worldwide, and its prevalence exponentially increases with age. It is related to increased risk of ischemic stroke or systemic embolism, which determines a significant burden of morbidity and mortality, as widely documented in the literature. AF also constitutes a risk factor for other less investigated conditions, such as heart failure, pulmonary embolism, impairment in physical performance, reduced quality of life and development of disability, mood disorders, and cognitive impairment up to dementia. In the elderly population, the management...
Source: Ageing Research Reviews - May 28, 2020 Category: Genetics & Stem Cells Authors: Bencivenga L, Komici K, Nocella P, Grieco FV, Spezzano A, Puzone B, Cannavo A, Cittadini A, Corbi G, Ferrara N, Rengo G Tags: Ageing Res Rev Source Type: research

Impact of frailty models on the prescription of oral anticoagulants and on the incidence of stroke, bleeding, and mortality in older patients with atrial fibrillation: a systematic review
CONCLUSIONS: Due to the great heterogeneity among different validated frailty measures, indiscriminately relying on "frailty" should not be regarded as the gold standard for clinical decision-making about stroke prevention in older AF patients. Present findings suggest that severe frailty according to the DAM is associated with less use of OAT and increased risk of all-cause mortality, thereby representing at the moment the most reasonable tool to efficiently recognize patients with limited life expectancy and for whom there is so far scant, if any, evidence of a clinical benefit of OAT.AVAILABILITY OF DATA AND MATERIAL: A...
Source: Ageing Research Reviews - October 21, 2022 Category: Genetics & Stem Cells Authors: Roberto Presta Enrico Brunetti Maria Cristina Polidori Mario Bo Source Type: research

Repetitive Transcranial Magnetic Stimulation Combined with Cognitive Training for Cognitive Function and Activities of Daily Living in Patients with Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis
CONCLUSIONS: The pooled data showed more positive effects of rTMS + cognitive training for global cognition, executive function, working memory and ADL in patients with PSCI. While, robust evidence of rTMS + cognitive training for global cognition, executive function, working memory and ADL from the Grade recommendations is lacking. Further, rTMS + cognitive training did not show no better effects on memory. Future definitive trials are needed to determine the benefits of rTMS + cognitive training for cognitive function and ADL in the field of PSCI.PMID:37004840 | DOI:10.1016/j.arr.2023.101919
Source: Ageing Research Reviews - April 2, 2023 Category: Genetics & Stem Cells Authors: Yong Gao Yue Qiu Qingyan Yang Shaowen Tang Jianqiu Gong Hong Fan Yuefeng Wu Xiao Lu Source Type: research

Introduction to Special Issue: Neurovascular Aging - a driving force for neurological dysfunction in stroke and neurodegenerative diseases.
PMID: 27793608 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - October 24, 2016 Category: Genetics & Stem Cells Authors: Graham SH Tags: Ageing Res Rev Source Type: research

Life and death in the trash heap: the ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
Abstract The ubiquitin proteasome pathway (UPP) is essential for removing abnormal proteins and preventing accumulation of potentially toxic proteins within the neuron. UPP dysfunction occurs with normal aging and is associated with abnormal accumulation of protein aggregates within neurons in neurodegenerative diseases. Ischemia disrupts UPP function and thus may contribute to UPP dysfunction seen in the aging brain and in neurodegenerative diseases. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1), an important component of the UPP in the neuron, is covalently modified and its activity inhibited by reactive lipid...
Source: Ageing Research Reviews - September 30, 2016 Category: Genetics & Stem Cells Authors: Graham SH, Liu H Tags: Ageing Res Rev Source Type: research

Aging of Cerebral White Matter.
Abstract White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas, WM undergoes a series of changes during the process of aging. WM malfunction can induce serious neurobehavioral and cognitive impairments. Thus, age-related changes in WM may contribute to the functional decline observed in the elderly. In addition, aged WM becomes more susceptible to neurol...
Source: Ageing Research Reviews - November 15, 2016 Category: Genetics & Stem Cells Authors: Liu H, Yang Y, Xia Y, Zhu W, Leak RK, Wei Z, Wang J, Hu X Tags: Ageing Res Rev Source Type: research