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Source: Acta Pharmacologica Sinica
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Total 122 results found since Jan 2013.
Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation.
In conclusion, these results reveal for the first time the potential anti-ischemic effects of RABE on neuronal and glial cells and elucidate the molecular mechanisms involved in its dual beneficial profiles in vitro. RABE may be a promising drug lead/candidate for the treatment of ischemic stroke.
PMID: 28216621 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - February 19, 2017 Category: Drugs & Pharmacology Authors: Wu L, Wang HM, Li JL, Feng HX, Zhao WM, Zhang HY Tags: Acta Pharmacol Sin Source Type: research
Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.
CONCLUSION: A considerable portion (11.66%) of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms.
PMID: 27641736 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - September 18, 2016 Category: Drugs & Pharmacology Authors: Peng LL, Zhao YQ, Zhou ZY, Jin J, Zhao M, Chen XM, Chen LY, Cai YF, Li JL, Huang M Tags: Acta Pharmacol Sin Source Type: research
Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice.
CONCLUSION: Probucol inhibits LPS-induced microglia activation and ameliorates cerebral ischemic injury in normal and hyperlipidemic mice via its anti-neuroinflammatory actions, suggesting that probucol has potential for the treatment of patients with or at risk for ischemic stroke and hyperlipidemia.
PMID: 27345627 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - June 26, 2016 Category: Drugs & Pharmacology Authors: Jung YS, Park JH, Kim H, Kim SY, Hwang JY, Hong KW, Bae SS, Choi BT, Lee SW, Shin HK Tags: Acta Pharmacol Sin Source Type: research
Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke.
CONCLUSION: The individuals with both the CYP2C19(*)2 allele and hypertension are at high risk of CR during anti-thrombosis therapy. The CYP3A4(*)1G allele, P2RY12 (rs2046934) C allele and NR1I2 (rs13059232) CC genotype may be protective factors for CR. The associated SNPs studied may be useful to predict clopidogrel resistance in Chinese patients with ischemic stroke.
PMID: 27133299 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 1, 2016 Category: Drugs & Pharmacology Authors: Liu R, Zhou ZY, Chen YB, Li JL, Yu WB, Chen XM, Zhao M, Zhao YQ, Cai YF, Jin J, Huang M Tags: Acta Pharmacol Sin Source Type: research
Functional implications of axon initial segment cytoskeletal disruption in stroke.
Abstract
Axon initial segment (AIS) is the proximal part of the axon, which is not covered with a myelin sheath and possesses a distinctive, specialized assembly of voltage-gated ion channels and associated proteins. AIS plays critical roles in synaptic integration and action potential generation in central neurons. Recent evidence shows that stroke causes rapid, irreversible calpain-mediated proteolysis of the AIS cytoskeleton of neurons surrounding the ischemic necrotic core. A better understanding of the molecular mechanisms underlying this "non-lethal" neuronal damage might provide new therapeutic strategies f...
Source: Acta Pharmacologica Sinica - December 21, 2015 Category: Drugs & Pharmacology Authors: Stoler O, Fleidervish IA Tags: Acta Pharmacol Sin Source Type: research
KCNQ potassium channels in sensory system and neural circuits.
Abstract
M channels, an important regulator of neural excitability, are composed of four subunits of the Kv7 (KCNQ) K(+) channel family. M channels were named as such because their activity was suppressed by stimulation of muscarinic acetylcholine receptors. These channels are of particular interest because they are activated at the subthreshold membrane potentials. Furthermore, neural KCNQ channels are drug targets for the treatments of epilepsy and a variety of neurological disorders, including chronic and neuropathic pain, deafness, and mental illness. This review will update readers on the roles of KCNQ channe...
Source: Acta Pharmacologica Sinica - December 21, 2015 Category: Drugs & Pharmacology Authors: Wang JJ, Li Y Tags: Acta Pharmacol Sin Source Type: research
Brain protection against ischemic stroke using choline as a new molecular bypass treatment.
CONCLUSION: Choline effectively attenuates brain ischemic injury in pMCAO rats, possibly by facilitating pial arteriogenesis and cerebral-cortical capillary angiogenesis via upregulating α7 nAChR levels and inducing the expression of HIF-1α and VEGF.
PMID: 26567726 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - November 16, 2015 Category: Drugs & Pharmacology Authors: Jin X, Wang RH, Wang H, Long CL, Wang H Tags: Acta Pharmacol Sin Source Type: research
Connexin 43 stabilizes astrocytes in a stroke-like milieu to facilitate neuronal recovery.
CONCLUSION: Cx43 can stabilize astrocytes and facilitate the resistance to the deleterious effects of a stroke-like milieu and promote neuronal recovery.
PMID: 26095039 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - June 22, 2015 Category: Drugs & Pharmacology Authors: Wu LY, Yu XL, Feng LY Tags: Acta Pharmacol Sin Source Type: research
Deciphering the pharmacological mechanism of the Chinese formula Huanglian-Jie-Du decoction in the treatment of ischemic stroke using a systems biology-based strategy.
CONCLUSION: This study has developed for the first time a comprehensive systems approach integrating drug target prediction, network analysis and molecular docking simulation to reveal the relationships between the herbs contained in HLJDD and their putative targets and ischemic stroke-related pathways.
PMID: 25937634 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 4, 2015 Category: Drugs & Pharmacology Authors: Zhang YQ, Wang SS, Zhu WL, Ma Y, Zhang FB, Liang RX, Xu HY, Yang HJ Tags: Acta Pharmacol Sin Source Type: research
Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice.
Conclusion:Chronic administration of dl-PHPB improves learning and memory and promotes LTP in the animal models of Alzheimer's disease, possibly via increasing p-GluN2B expression in the hippocampus.
PMID: 24858312 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 26, 2014 Category: Drugs & Pharmacology Authors: Li PP, Wang WP, Liu ZH, Xu SF, Lu WW, Wang L, Wang XL Tags: Acta Pharmacol Sin Source Type: research
Glutamate transporters in brain ischemia: to modulate or not?
Abstract
In this review, we briefly describe glutamate (Glu) metabolism and its specific transports and receptors in the central nervous system (CNS). Thereafter, we focus on excitatory amino acid transporters, cystine/glutamate antiporters (system xc-) and vesicular glutamate transporters, specifically addressing their location and roles in CNS and the molecular mechanisms underlying the regulation of Glu transporters. We provide evidence from in vitro or in vivo studies concerning alterations in Glu transporter expression in response to hypoxia or ischemia, including limited human data that supports the role of ...
Source: Acta Pharmacologica Sinica - March 31, 2014 Category: Drugs & Pharmacology Authors: Krzyżanowska W, Pomierny B, Filip M, Pera J Tags: Acta Pharmacol Sin Source Type: research
Dietary salt intake and stroke.
PMID: 23274412 [PubMed - in process]
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: Turlova E, Feng ZP Tags: Acta Pharmacol Sin Source Type: research
Restoring neuroprotection through a new preclinical paradigm: translational success for NA-1 in stroke therapy.
PMID: 23262667 [PubMed - in process]
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: Instrum R, Sun HS Tags: Acta Pharmacol Sin Source Type: research
The good and bad of microglia/macrophages: new hope in stroke therapeutics.
PMID: 23262666 [PubMed - in process]
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: Huang YC, Feng ZP Tags: Acta Pharmacol Sin Source Type: research
Current mechanisms in stroke.
PMID: 23262665 [PubMed - in process]
Source: Acta Pharmacologica Sinica - January 1, 2013 Category: Drugs & Pharmacology Authors: Sun HS Tags: Acta Pharmacol Sin Source Type: research
