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Source: Cell Research
Vaccination: Cancer Vaccines
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Total 154 results found since Jan 2013.
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Madhav V Dhodapkar Source Type: research
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
CONCLUSIONS: Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.PMID:37735756 | DOI:10.1158/1078-0432.CCR-22-3987
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Ciara L Freeman Reginald Atkins Indumathy Varadarajan Meghan Menges Jeffrey Edelman Rachid Baz Jason Brayer Omar Castaneda Puglianini Jose Leonel Ochoa-Bayona Taiga Nishihori Kenneth H Shain Bijal Shah Dung Tsa Chen Linda Kelley Domenico Coppola Melissa A Source Type: research
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
Turning anecdotal irradiation-induced anti-cancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells
In conclusion, our novel approach generated an anti-cancer immune response, resulting in a lack of or low tumor incidence post-rechallenge and robust AEs, i.e., the absence of or decreased spontaneous lung metastasis in tumor-bearing mice. This approach is readily translatable to clinical settings and may increase IR-induced AEs in cancer patients.PMID:37645899 | PMC:PMC10462241 | DOI:10.21203/rs.3.rs-3195392/v1
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Xinhui Wang Wei Guo Lin Jia Ling Xie Juliann Kiang Yangyang Wang Fuyou Wang Zunwen Lin Enwen Wang Yida Zhang Peigen Huang Ting Sun Xiao Zhang Zhengying Bian Tiejun Tang Jingtian Guo Soldano Ferrone Source Type: research
Recent advances and applications of peptide-agent conjugates for targeting tumor cells
CONCLUSIONS: This review highlights the potential of ACPs as a promising therapeutic option for cancer treatment, particularly through the use of peptide vaccines and peptide-drug conjugates. Despite the limitations of peptides, such as poor metabolic stability and low bioavailability, modified peptides show promise in addressing these challenges. Various mechanism of action of anticancer peptides. Modes of action against cancer cells including: inducing apoptosis by cytochrome c release, direct cell membrane lysis (necrosis), inhibiting angiogenesis, inducing autophagy-mediated cell death and immune cell regulation.PMID:3...
Source: Cell Research - August 15, 2023 Category: Cytology Authors: Vahab Alamdari-Palangi Khojaste Rahimi Jaberi Mahshid Shahverdi Yasaman Naeimzadeh Amir Tajbakhsh Sahar Khajeh Vahid Razban Jafar Fallahi Source Type: research
Liquid nitrogen frozen cells for chemotherapy drug delivery and vaccination of melanoma
CONCLUSION: In this work, we obtain the LNF cells with a simple procedure. The LNF cells not only provides a tumor cells-based multi-modal system for cancer therapy but inspires new insights into future development of individualized CVs strategies. This study processes live B16F10 cells by liquid nitrogen frozen to obtain LNF cells, which preserve cell integrity and homologous targeting ability. The LNF cells can load and deliver drug and can serve as tumor vaccine. Results demonstrated the LNF cells have effective prophylactic ability, and ideal anti-tumor ability with the loaded drug and adjuvant.PMID:37522925 | DOI:10.1...
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Minliang Wu Yuai Xiao Jianguo Huang Yuchong Wang Yifan Zhang Jianguo Xu Haiying Dai Chuan Lv Yihui Hu Bingdi Chen Qingge Fu Wenjun Le Chunyu Xue Source Type: research
Sequential Chromogenic IHC: Spatial Analysis of Lymph Nodes Identifies Contact Interactions between Plasmacytoid Dendritic Cells and Plasmablasts
We present a comprehensive guide for developing customized biomarker panels to investigate cell-cell interactions in the context of immune responses in cancer. This approach revealed novel contact interactions between plasmablasts and plasmacytoid dendritic cells in lymph nodes from patients with head and neck cancer.PMID:37484199 | PMC:PMC10361537 | DOI:10.1158/2767-9764.CRC-23-0102
Source: Cell Research - July 24, 2023 Category: Cytology Authors: Natalie Claudio My-Tien Nguyen Adrian Wanner Ferdinando Pucci Source Type: research
New immunotherapeutic approaches for cancer treatment
Pathol Res Pract. 2023 Jun 19;248:154632. doi: 10.1016/j.prp.2023.154632. Online ahead of print.ABSTRACTNeoplasms are a worldwide recognized non-contagious disease which has the most mortality rate after cardiovascular diseases. For decades, there has been a vast amount of study on treatment methods of cancer which has led to conventional therapies such as chemotherapy, radiation therapy, surgery and so on. Clinicians and researchers believed that there is an urgent need, considering the high rate of incidence and prevalence, for an alternative treatment option which is more efficacious and has less adverse effects than th...
Source: Cell Research - July 22, 2023 Category: Cytology Authors: Amin Kamrani Ramin Hosseinzadeh Navid Shomali Javad Ahmadian Heris Parviz Shahabi Reza Mohammadinasab Shahram Sadeghvand Kazem Ghahremanzadeh Mohammadreza Sadeghi Morteza Akbari Source Type: research
Randomized Trial of a Personalized Dendritic Cell Vaccine after Autologous Stem Cell Transplant for Multiple Myeloma
CONCLUSIONS: DC/MM fusion vaccination with lenalidomide did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating MM-reactive lymphocytes indicative of tumor-specific immunity. Site-specific production of a personalized cell therapy with centralized product characterization was effectively accomplished in the context of a multicenter cooperative group study.PMID:37463058 | DOI:10.1158/1078-0432.CCR-23-0235
Source: Cell Research - July 18, 2023 Category: Cytology Authors: David J Chung Nina Shah Juan Wu Brent Logan Lina Bisharat Natalie Callander Giulia Cheloni Kenneth Anderson Thinle Chodon Binod Dhakal Steven Devine Poorvi Somaiya Dutt Yvonne Efebera Nancy Geller Haider Ghiasuddin Peiman Hematti Leona Holmberg Alan Howar Source Type: research
rWTC-MBTA: autologous vaccine prevents metastases via antitumor immune responses
CONCLUSION: The rWTC-MBTA vaccine demonstrated efficacy in multiple animal models through T-cell mediated cytotoxicity and has potential as a therapeutic option for preventing and treating tumor metastasis with minimal systemic toxicity.PMID:37434263 | DOI:10.1186/s13046-023-02744-8
Source: Cell Research - July 11, 2023 Category: Cytology Authors: Juan Ye Herui Wang Rogelio Medina Samik Chakraborty Mitchell Sun Alex Valenzuela Xueyu Sang Yaping Zhang Ondrej Uher Jan Zenka Karel Pacak Zhengping Zhuang Source Type: research
Tumor neoantigens: Novel strategies for application of cancer immunotherapy
Oncol Res. 2023 Jun 27;31(4):437-448. doi: 10.32604/or.2023.029924. eCollection 2023.ABSTRACTNeoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer. The recognition of antigens by immune cells is a crucial step in tumor-specific killing, and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells, making them an attractive therapeutic target. Currently, neoantigens find utility in various domains, primarily in the realm of neoantigen vaccines such as DC vaccines, nucleic acid vaccines, and synthetic long...
Source: Cell Research - July 7, 2023 Category: Cytology Authors: Hanyang Guan Yue Wu L U Li Yabing Yang Shenghui Qiu Zhan Zhao Xiaodong Chu Jiashuai He Zuyang Chen Yiran Zhang Hui Ding Jinghua Pan Yunlong Pan Source Type: research
Non-interfacial self-assembly of synthetic protocells
CONCLUSION: This synthetic protocell fabricated by the NISA method simulates the occurrence and development process of primitive life, which has great potential application value in mRNA vaccine, cancer immunotherapy, and drug delivery.PMID:37400932 | DOI:10.1186/s40824-023-00402-w
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Xiaolin Xu Wencai Guan Xiaolei Yu Guoxiong Xu Chenglong Wang Source Type: research
Clinical Activity of Combined Telomerase Vaccination and Pembrolizumab in Advanced Melanoma: Results from a Phase I Trial
CONCLUSIONS: Encouraging safety and preliminary efficacy were observed. Randomized phase II trials are currently ongoing.PMID:37378632 | DOI:10.1158/1078-0432.CCR-23-0416
Source: Cell Research - June 28, 2023 Category: Cytology Authors: Espen B Ellingsen Steven O'Day Artur Mezheyeuski Agnieszka Gromadka Trevor Clancy Timothy S Kristedja Mohammed Milhem Yousef Zakharia Source Type: research
