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Total 1790 results found since Jan 2013.

Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion
Transl Stroke Res. 2023 Jun 16. doi: 10.1007/s12975-023-01164-2. Online ahead of print.ABSTRACTRepulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain injury, acute ischemic stroke (AIS), and other neuropathological conditions. Neutralization of RGMa is neuroprotective and promotes neuroplasticity in several preclinical models of neurodegeneration and injury including multiple sclerosis, AIS, and SCI. Given the limitations of current treatments for AIS due to narrow time windows ...
Source: Cell Research - June 16, 2023 Category: Cytology Authors: Peer B Jacobson Andrea Mothe Aharon Levy Michael Krakovsky Bradley A Hooker Xiaomeng Zhang Jennifer Mollon Yulia Mordashova Mathias Droescher Sabine Weiss Stefan Barghorn Ingeborg Dreher Khader Awwad Volker Nimmrich Lili Huang Emma Fung Wayne R Buck Kimbe Source Type: research

Transapical Transcatheter Mitral Valve Implantation with the Tendyne Valve: The Swiss Experience
CONCLUSION: Transcatheter mitral valve implantation with Tendyne is feasible to treat polymorbid patients suffering from complex mitral valve disease as well as patients with previous mitral interventions. Perioperative risk was acceptable and procedural success high.PMID:37327913 | DOI:10.1055/s-0043-1769099
Source: The Thoracic and Cardiovascular Surgeon - June 16, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Maria Nucera Jules Miazza Fabien Praz Christoph Kaiser Matthias Siepe David Reineke Oliver Reuthebuch Source Type: research

The intestinal γδ T cells: functions in the gut and in the distant organs
Located in the frontline against the largest population of microbiota, the intestinal mucosa of mammals has evolved to become an effective immune system. γδ T cells, a unique T cell subpopulation, are rare in circulation blood and lymphoid tissues, but rich in the intestinal mucosa, particularly in the epithelium. Via rapid production of cytokines and growth factors, intestinal γδ T cells are key contributors to epithelial homeostasis and immune surveillance of infection. Intriguingly, recent studies have revealed that the intestinal γδ T cells may play novel exciting functions ranging from epithelial plasticity and ...
Source: Frontiers in Immunology - June 16, 2023 Category: Allergy & Immunology Source Type: research

Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion
AbstractRepulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain injury, acute ischemic stroke (AIS), and other neuropathological conditions. Neutralization of RGMa is neuroprotective and promotes neuroplasticity in several preclinical models of neurodegeneration and injury including multiple sclerosis, AIS, and SCI. Given the limitations of current treatments for AIS due to narrow time windows to intervention (TTI), and restrictive patient selection criteria, there is significant...
Source: Translational Stroke Research - June 16, 2023 Category: Neurology Source Type: research