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Total 3962 results found since Jan 2013.

Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula Brief Reports
Conclusions— Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Garcia-Cordero, I., Sedeno, L., Fraiman, D., Craiem, D., de la Fuente, L. A., Salamone, P., Serrano, C., Sposato, L., Manes, F., Ibanez, A. Tags: Computerized tomography and Magnetic Resonance Imaging, Other imaging, Pathology of Stroke Brief Reports Source Type: research

Damage to the Left Precentral Gyrus Is Associated With Apraxia of Speech in Acute Stroke Clinical Sciences
Conclusions— Damage to the left precentral gyrus is associated with AOS in acute to subacute stroke patients, suggesting a role of this brain region in motor speech production.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Itabashi, R., Nishio, Y., Kataoka, Y., Yazawa, Y., Furui, E., Matsuda, M., Mori, E. Tags: Computerized Tomography (CT), Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Cognitive Impairment, Ischemic Stroke Clinical Sciences Source Type: research

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis Basic Sciences
Conclusions— Our results provide the basis needed for the design of future preclinical studies on recanalization therapies using this model of thromboembolic stroke in mice. The power analysis reveals that a multicenter trial would require 123 animals per group instead of 40 for a single-center trial.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Orset, C., Haelewyn, B., Allan, S. M., Ansar, S., Campos, F., Cho, T. H., Durand, A., El Amki, M., Fatar, M., Garcia-Yebenes, I., Gauberti, M., Grudzenski, S., Lizasoain, I., Lo, E., Macrez, R., Margaill, I., Maysami, S., Meairs, S., Nighoghossian, N., Or Tags: Animal Models of Human Disease, Ischemic Stroke Basic Sciences Source Type: research

FABS: An Intuitive Tool for Screening of Stroke Mimics in the Emergency Department Clinical Sciences
Conclusions— FABS seems to be reliable in stratifying SM from acute cerebral ischemia cases among patients in whom the head computed tomography was negative for any acute findings. It can help clinicians consider advanced imaging for further diagnosis.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Goyal, N., Tsivgoulis, G., Male, S., Metter, E. J., Iftikhar, S., Kerro, A., Chang, J. J., Frey, J. L., Triantafyllou, S., Papadimitropoulos, G., Abedi, V., Alexandrov, A. W., Alexandrov, A. V., Zand, R. Tags: Ischemic Stroke Clinical Sciences Source Type: research

Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling Clinical Sciences
Background and Purpose—Perfusion-weighted imaging is used to select patients with acute ischemic stroke for intervention, but knowledge of cerebral perfusion can also inform the understanding of ischemic injury. Arterial spin labeling allows repeated measurement of absolute cerebral blood flow (CBF) without the need for exogenous contrast. The aim of this study was to explore the relationship between dynamic CBF and tissue outcome in the month after stroke onset.Methods—Patients with nonlacunar ischemic stroke underwent ≤5 repeated magnetic resonance imaging scans at presentation, 2 hours, 1 day, 1 week, and 1 month....
Source: Stroke - December 22, 2016 Category: Neurology Authors: George W.J. Harston, Thomas W. Okell, Fintan Sheerin, Ursula Schulz, Phil Mathieson, Ian Reckless, Kunal Shah, Gary A. Ford, Michael A. Chappell, Peter Jezzard, James Kennedy Tags: Ischemic Stroke Original Contributions Source Type: research

Regional Comparison of Multiphase Computed Tomographic Angiography and Computed Tomographic Perfusion for Prediction of Tissue Fate in Ischemic Stroke Clinical Sciences
Background and Purpose—Within different brain regions, we determine the comparative value of multiphase computed tomographic angiography (mCTA) and computed tomographic perfusion (CTP) in predicting follow-up infarction.Methods—Patients with M1-middle cerebral artery occlusions were prospectively included in this multicenter study. Regional analysis was performed for each patient within Alberta Stroke Program Early CT Score regions M2 to M6. Regional pial vessel filling was assessed on mCTA in 3 ways: (1) Washout of contrast within pial vessels; (2) Extent of maximal pial vessel enhancement compared with contralateral ...
Source: Stroke - March 27, 2017 Category: Neurology Authors: Christopher D. d’Esterre, Anurag Trivedi, Pooneh Pordeli, Mari Boesen, Shivanand Patil, Seong Hwan Ahn, Mohamed Naȷm, Enrico Fainardi, Jai Jai Shiva Shankar, Marta Rubiera, Mohammed A. Almekhlafi, Jennifer Mandzia, Alexander V. Khaw, Philip Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Arterial Wall Imaging in Pediatric Stroke Clinical Sciences
Conclusions—AWI is a noninvasive, high-resolution magnetic resonance AWI technique, which can be successfully used in children presenting with AIS. Patterns of AWI enhancement are recognizable and associated with specific AIS pathogeneses. Further studies are required to assess the additional diagnostic utility of AWI over routine vascular imaging techniques, in childhood AIS.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Nomazulu Dlamini, Ivanna Yau, Prakash Muthusami, David J. Mikulis, Jorina Elbers, Mahmoud Slim, Rand Askalan, Daune MacGregor, Gabrielle deVeber, Manohar Shroff, Mahendranath Moharir Tags: Pediatrics, Imaging, Ischemic Stroke, Vascular Disease Original Contributions Source Type: research

Early New Diffusion-Weighted Imaging Lesions Appear More Often in Stroke Patients With a Multiple Territory Lesion Pattern Clinical Sciences
Conclusion— Lesion pattern on initial image is an independent risk factor for new DWI lesions. The risk for new DWI lesions is highest in patients with multiple territory lesion pattern.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Braemswig, T. B., Usnich, T., Albach, F. N., Brunecker, P., Grittner, U., Scheitz, J. F., Fiebach, J. B., Nolte, C. H. Tags: CT and MRI, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke Clinical Sciences Source Type: research

Gradual Lesion Expansion and Brain Shrinkage Years After Stroke Brief Reports
Conclusions— We show gradual lesion expansion many years after stroke, beyond that expected by normal aging and after controlling for other variables. Future studies need to understand how structural reorganization enables long-term recovery even when the brain is shrinking.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Seghier, M. L., Ramsden, S., Lim, L., Leff, A. P., Price, C. J. Tags: Behavioral Changes and Stroke, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Relationships Between Imaging Assessments and Outcomes in Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke Clinical Sciences
Conclusions— Patients who achieved reperfusion had substantially more favorable clinical and imaging outcomes in both the intervention and the control groups. Infarct volume at 27 hours strongly correlated with clinical outcome at 90 days in both treatment groups. SWIFT PRIME patients with the target mismatch profile had a highly favorable response to endovascular therapy on both clinical and imaging outcomes. Both reperfusion and infarct volumes at 27 hours were powerful and independent predictors of 90-day clinical outcomes. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01657461.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Albers, G. W., Goyal, M., Jahan, R., Bonafe, A., Diener, H.-C., Levy, E. I., Pereira, V. M., Cognard, C., Yavagal, D. R., Saver, J. L. Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Role of Genetic Variation in Collateral Circulation in the Evolution of Acute Stroke Basic Sciences
We examined ischemic tissue evolution during acute stroke, as measured by magnetic resonance imaging and histology, by comparing 2 congenic mouse strains with otherwise identical genetic backgrounds but with different alleles of the Determinant of collateral extent-1 (Dce1) genetic locus. We also optimized magnetic resonance perfusion and diffusion–deficit thresholds by using histological measures of ischemic tissue.Methods—Perfusion, diffusion, and T2-weighted magnetic resonance imaging were performed on collateral-poor (congenic-Bc) and collateral-rich (congenic-B6) mice at 1, 5, and 24 hours after permanent middle c...
Source: Stroke - February 26, 2017 Category: Neurology Authors: Yu-Chieh Jill Kao, Esteban A. Oyarzabal, Hua Zhang, James E. Faber, Yen-Yu Ian Shih Tags: Genetics, Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research

Multiparametric Model for Penumbral Flow Prediction in Acute Stroke Clinical Sciences
In this study, we established a multiparametric perfusion imaging model and cross-validated it using positron emission tomography perfusion for detection of penumbral flow.Methods—In a retrospective analysis of 17 subacute stroke patients with consecutive magnetic resonance imaging and H2O15 positron emission tomography scans, perfusion maps of cerebral blood flow, cerebral blood volume, mean transit time, time-to-maximum, and time-to-peak were constructed and combined using a generalized linear model (GLM). Both the GLM maps and the single perfusion maps alone were cross-validated with positron emission tomography-cereb...
Source: Stroke - June 26, 2017 Category: Neurology Authors: Michelle Livne, Tabea Kossen, Vince I. Madai, Olivier Zaro-Weber, Walter Moeller-Hartmann, Kim Mouridsen, Wolf-Dieter Heiss, Jan Sobesky Tags: Imaging, Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research

Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Stroke Thrombolysis Clinical Sciences
Background and Purpose—We assessed whether the presence, number, and distribution of cerebral microbleeds (CMBs) on pre-intravenous thrombolysis MRI scans of acute ischemic stroke patients are associated with an increased risk of intracerebral hemorrhage (ICH) or poor functional outcome.Methods—We performed an individual patient data meta-analysis, including prospective and retrospective studies of acute ischemic stroke treated with intravenous tissue-type plasminogen activator. Using multilevel mixed-effects logistic regression, we investigated associations of pre-treatment CMB presence, burden (1, 2–4, ≥5, and>10...
Source: Stroke - July 24, 2017 Category: Neurology Authors: Andreas Charidimou, Guillaume Turc, Catherine Oppenheim, Shenqiang Yan, Jan F. Scheitz, Hebun Erdur, Pascal P. Klinger–Gratz, Marwan El–Koussy, Wakoh Takahashi, Yusuke Moriya, Duncan Wilson, Chelsea S. Kidwell, Jeffrey L. Saver, Asma Sallem, S Tags: Magnetic Resonance Imaging (MRI), Prognosis, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

DWI-ASPECTS (Diffusion-Weighted Imaging-Alberta Stroke Program Early Computed Tomography Scores) and DWI-FLAIR (Diffusion-Weighted Imaging-Fluid Attenuated Inversion Recovery) Mismatch in Thrombectomy Candidates Brief Report
Conclusions—Agreement between clinicians assessing DWI-ASPECTS and DWI-FLAIR mismatch may not be sufficient to make repeatable clinical decisions in mechanical thrombectomy. The dichotomization of the DWI-ASPECTS (0–5 versus 0–6 or 0–6 versus 7–10) improved interrater and intrarater agreement, however, its relevance for patients selection for mechanical thrombectomy needs to be validated in a randomized trial.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Robert Fahed, Augustin Lecler, Candice Sabben, Naim Khoury, Celina Ducroux, Vanessa Chalumeau, Daniele Botta, Erwah Kalsoum, William Boisseau, Loic Duron, Dominique Cabral, Patricia Koskas, Azzedine Benaissa, Hasmik Koulakian, Michael Obadia, Benȷa Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Brief Reports Source Type: research

Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke Clinical Sciences
Background and Purpose—It has been hypothesized that cerebral small vessel disease (SVD) and chronic renal impairment may be part of a multisystem small-vessel disorder, but their association may simply be as a result of shared risk factors (eg, hypertension) rather than to a systemic susceptibility to premature SVD. However, most previous studies were hospital based, most had inadequate adjustment for hypertension, many were confined to patients with lacunar stroke, and none stratified by age.Methods—In a population-based study of transient ischemic attack and ischemic stroke (OXVASC [Oxford Vascular Study]), we evalu...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Bian Liu, Kui Kai Lau, Linxin Li, Caroline Lovelock, Ming Liu, Wilhelm Kuker, Peter M. Rothwell Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research