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Effect of B Vitamins and Lowering Homocysteine on Cognitive Impairment in Patients With Previous Stroke or Transient Ischemic Attack: A Prespecified Secondary Analysis of a Randomized, Placebo-Controlled Trial and Meta-Analysis Clinical Sciences
Conclusions— Daily supplementation with folic acid, vitamin B6, and vitamin B12 to a self-selected clinical trial cohort of cognitively unimpaired patients with previous stroke or transient ischemic attack lowered mean tHcy but had no effect on the incidence of cognitive impairment or cognitive decline, as measured by the MMSE, during a median of 2.8 years. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN74743444; URL: http://www.clinicaltrials.gov. Unique identifier: NCT00097669.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Hankey, G. J., Ford, A. H., Yi, Q., Eikelboom, J. W., Lees, K. R., Chen, C., Xavier, D., Navarro, J. C., Ranawaka, U. K., Uddin, W., Ricci, S., Gommans, J., Schmidt, R., Almeida, O. P., van Bockxmeer, F. M., on Behalf of the VITATOPS Trial Study Group Tags: Other Treatment, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Reservations against new oral anticoagulants after stroke and cerebral bleeding
Abstract: Dabigatran, rivaroxaban, and apixaban are the new oral anticoagulants (NOAC) which have been investigated in patients with atrial fibrillation (AF) for primary and secondary prevention of stroke and thromboembolism. In these trials NOAC had a similar efficacy and safety profile compared to traditional vitamin-K-antagonists such as warfarin. We advise caution in the use of NOAC in patients with stroke or cerebral hemorrhage because of the following reasons:1) Patients with cerebral bleeding were excluded from the trials. 2) Stroke within 14days and severe stroke within 6months before screening were exclusion crite...
Source: Journal of the Neurological Sciences - April 29, 2013 Category: Neurology Authors: Claudia Stöllberger, Josef Finsterer Tags: Opinion Source Type: research

The China Stroke Secondary Prevention Trial (CSSPT) protocol: a double‐blinded, randomized, controlled trial of combined folic acid and B vitamins for secondary prevention of stroke
DiscussionThis is the first multicenter randomized trial of secondary prevention for ischemic stroke in a Chinese population with a higher homocysteine level but without folate food fortification.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Xuedong Liu, Ming Shi, Feng Xia, Junliang Han, Zhirong Liu, Bo Wang, Fang Yang, Li Li, Songdi Wu, Ling Wang, Nan Liu, Yali Lv, Gang Zhao Tags: Protocols Source Type: research

Arterial ischemic stroke and hemorrhagic stroke in Chinese children: A retrospective analysis
This study retrospectively reviewed the records of all patients in both department of neurology and department of neurosurgery in Children’s hospital of Chongqing medical university from January 2003 to March 2011, and patients were eligible for analysis if they had been diagnosed with AIS or HS. And SPSS 17.0 software was used for statistical analysis. The χ2 test was used to exam relationships between stroke types and sex, age, and that between neuroradiological images and sex. 119 Boys (70.4%) and 50 girls (29.6%) were included. In these cases, HS accounted for the majority of the cases (n=109, 64.1%), and vitamin K ...
Source: Brain and Development - March 4, 2013 Category: Neurology Authors: Ling-ling Xie, Li Jiang Tags: Original articles Source Type: research

Assessment of Vitamin D Deficiency in Patients with Neurological Disorders (P03.271)
CONCLUSIONS: The results of the present study may have been biased by the type of the study population (hospital-based) and the small size of the sample. However, the frequent association between Vitamin D deficiency and neurologic disorders indicates that this vitamin may have a fundamental role in physiologic and pathological processes of the Nervous System, particularly in patients over 65 years of age. Vitamin D deficiency should be investigated routinely in clinical practice as the detection of this parameter may have important therapeutic implications.Disclosure: Dr. Triggiani has nothing to disclose. Dr. Barracchini...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Triggiani, L., Barracchini, A., Corona, R., Minisola, G. Tags: P03 Neural Repair Source Type: research

Effect of Low-Dose Aspirin on Functional Outcome From Cerebral Vascular Events in Women Original Contributions
Conclusions— Results from this large randomized clinical trial provide evidence that 100 mg of aspirin every other day may reduce the risk of ischemic cerebral vascular events but does not have differential effects on functional outcomes from stroke.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Rist, P. M., Buring, J. E., Kase, C. S., Kurth, T. Tags: Acute Cerebral Infarction, Epidemiology Original Contributions Source Type: research

Thromboembolic risks of recombinant factor VIIa Use in warfarin-associated intracranial hemorrhage: a case¿control study
Background: Recombinant factor VIIa (rFVIIa) may be used for rapid hemostasis in life-threatening hemorrhage. In warfarin-associated intracerebral hemorrhage (wICH), FVIIa use is controversial and may carry significant thromboembolic risks. We compared incidence of baseline thromboembolic risk factors and thromboembolism rates in wICH patients treated with additional rFVIIa to those treated with standard therapy of fresh frozen plasma (FFP) and vitamin K alone. Methods: We identified 45 consecutive wICH patients treated with additional rFVIIa over 5-year period, and 34 consecutive wICH patients treated with standard therap...
Source: BMC Neurology - December 15, 2012 Category: Neurology Authors: Chou H-YCai XuemeiKonigsberg GBresette MHenderson VSorond AFeske K Source Type: research

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