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An Optimal Animal Model of Ischemic Stroke Established by Digital Subtraction Angiography-Guided Autologous Thrombi in Cynomolgus Monkeys
ConclusionOur study may provide an optimal non-human primate model for an in-depth study of the pathogenesis and treatment of focal cerebral ischemia.
Source: Frontiers in Neurology - April 25, 2022 Category: Neurology Source Type: research

CPCGI confers neuroprotection by enhancing blood circulation and neurological function in cerebral ischemia/reperfusion rats.
Authors: Miao Y, Wang R, Wu H, Yang S, Qiu Y Abstract The current study used a rat middle cerebral artery occlusion (MCAO) model with the aim to explore the effects of compound porcine cerebroside and ganglioside injection (CPCGI) on brain ischemia/reperfusion injury in rats. Improvement in the infarct‑side microcirculation and the overall recovery of neurological function were detected by triphenyltetrazolium chloride staining, laser speckle blood flow monitoring, latex perfusion, immunofluorescence and immunoblotting. The results revealed that administration of CPCGI for 7 consecutive days following ischemic ...
Source: Molecular Medicine Reports - July 21, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Ketamine improves neuronal recovery following spreading depolarization in peri ‐infarct tissues
We examined spreading depolarization (SD) waves in a mouse stroke model. SDs were initiated by focal potassium chloride application and propagated through a region of graded perfusion deficit created by distal middle cerebral artery (dMCA) occlusion. Longer lasting depolarizations (DC shifts measured from local field potential (LFP) electrodes) and neuronal Ca2+ transients (epifluorescence GCaMP imaging) occurred at locations with larger perfusion deficits (proximal to occlusion), as compared with remote recording sites (laser speckle contrast imaging (LSCI) of cerebral perfusion). Ketamine, at concentrations that did not ...
Source: Journal of Neurochemistry - August 19, 2023 Category: Neuroscience Authors: Katelyn M. Reinhart, Russell A. Morton, K. C. Brennan, Andrew P. Carlson, C. William Shuttleworth Tags: ORIGINAL ARTICLE Source Type: research