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Non eosinophilic chronic stricturing esophagitis: lessons from thirty eight cases
CONCLUSION: The management of non-eosinophilic chronic stricturing esophagitis is challenging, because of a low contribution of esophageal biopsies and the refractory nature of the strictures. In our experience, a dermatological evaluation helped in 55% of cases to introduce a systemic treatment, leading to limit the use of endoscopic dilatation. Endoscopic follow-up is needed, considering the significant risk of esophageal squamous cell carcinoma.PMID:37657720 | DOI:10.1016/j.clinre.2023.102202
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Flavius-Stefan Marin Antoine Assaf Sarra Oumrani Vannina Seta Marianne Gaudric Fr édéric Beuvon Arthur Belle Romain Coriat Nicolas Dupin Stanislas Chaussade Maximilien Barret Source Type: research

Mild asthma: Lessons learned and remaining questions
Respir Med. 2023 Jun 14:107326. doi: 10.1016/j.rmed.2023.107326. Online ahead of print.ABSTRACTPatients living with mild disease represent the largest proportion of asthma patients. There are significant challenges in proposing a definition that would best describe these patients, while also accurately identifying at-risk individuals. Current literature suggests considerable inflammatory and clinical heterogeneity within this group. Research has shown that these patients are at risk of poor control, exacerbations, lung function decline, and death. Despite conflicting data on its prevalence, eosinophilic inflammation appear...
Source: Respiratory Care - June 16, 2023 Category: Respiratory Medicine Authors: Arjun Mohan Njira L Lugogo Source Type: research

Investigational medications in 9,638 hospitalized patients with severe COVID-19: lessons from the "fail-and-learn" strategy during the first two waves of the pandemic in 2020
CONCLUSION: This retrospective multicenter observational cohort study on 9,638 hospitalized patients with severe COVID-19 during revealed that the necessity for invasive ventilation had the highest odds of mortality, beyond the variable effects observed by administration of the prevalent EUA-approved investigational drugs during the first two surges of the early 2020 pandemic in the United States.PMID:37041643 | PMC:PMC10088131 | DOI:10.1186/s13037-023-00358-9
Source: Patient Safety in Surgery - April 11, 2023 Category: Surgery Authors: Adam C Delgado Brendon Cornett Ye Ji Choi Christina Colosimo Vincent P Stahel Oliwier Dziadkowiec Philip F Stahel Source Type: research

Lessons from tadpoles on the physiological roles of corticosteroids
Endocrinology. 2023 Jan 10:bqad002. doi: 10.1210/endocr/bqad002. Online ahead of print.NO ABSTRACTPMID:36624971 | DOI:10.1210/endocr/bqad002
Source: Endocrinology - January 10, 2023 Category: Endocrinology Authors: Alex M Schreiber Source Type: research

Reducing short-acting beta-agonist overprescribing in asthma: lessons from a quality-improvement prescribing project in East London
CONCLUSION: In this multi-ethnic population a fifth of practices demonstrate an overprescribing rate of <20% a year. Based on previous data, supporting practices to enable the SABA ≥12 group to reduce to 4-12 a year could potentially save up to 70% of asthma admissions a year within that group.PMID:35995577 | DOI:10.3399/BJGP.2021.0725
Source: The British Journal of General Practice - August 22, 2022 Category: Primary Care Authors: Anna De Simoni Hajar Hajmohammadi Paul Pfeffer Jim Cole Chris Griffiths Sally A Hull Source Type: research

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