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Total 16 results found since Jan 2013.

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

UCLA, USC get $2M to develop stroke center network in Southland
Stroke is the second leading cause of death in Los Angeles County and the fourth in the U.S. In order to cut those numbers, it's imperative that new treatments be developed and refined for stroke prevention, acute therapy and recovery after stroke.   Now, a three-way partnership between the UCLA Stroke Center at Ronald Reagan UCLA Medical Center, the USC Comprehensive Stroke and Cerebrovascular Center at Keck Medicine of USC, and UC Irvine has been awarded a $2 million grant from the National Institutes of Health to address these three stroke priorities.   Together, the three universities will form the Los A...
Source: UCLA Newsroom: Health Sciences - October 15, 2013 Category: Universities & Medical Training Source Type: news

Researcher Studies Statins for Stroke Therapy
Stacy Pigott A $2.8 million grant may help develop an improved therapeutic treatment for acute ischemic stroke patients to let them recover faster with fewer long-term complications. The protocol hinges on effectively delivering statins to the brain, where their neuroprotective properties can help save tissue damaged by stroke. Aug. 7, 2020 University of Arizona Health Sciencesnhg-PATRICK-RONALDSON_DSC6492-web.jpg Patrick Ronaldson (right), associate professor in the College of Medicine – Tucson's Department of Pharmacology, and doctoral students Erica Williams and Robert Betterton discuss their latest researc...
Source: The University of Arizona: Health - August 6, 2020 Category: Universities & Medical Training Authors: mittank Source Type: research

Cholesterol buildup in brain presents new target to reduce dementia risk from stroke
University of Arizona Health Sciences researchers suggest the risk of developing dementia after a stroke might be reduced by a drug that could help immune cells process the cholesterol-rich debris generated by a stroke. Today University of Arizona Health SciencesHealthBIO5College of Medicine - TucsonCollege of PharmacyExploration Media contact(s)Anna Christensen University of Arizona Health Sciencesachristensen@arizona.edu520-626-7383University of Arizona Health Sciences researchers discovered a potential treatment to reduce the risk of post-stroke dementia, which may be influenced by the immune response to dead bra...
Source: The University of Arizona: Health - January 19, 2022 Category: Universities & Medical Training Authors: mittank Source Type: research

National Institutes of Health Stroke Scale in Plain English Is Reliable for Novice Nurse Users with Minimal Training
Discussion With minimal or no training, novice nurse users of the NIHSS-PE can do as well as, if not better than, novice users of the NIHSS, making this tool useful for facilities pursuing Acute Stroke-Ready certification.
Source: Journal of Emergency Nursing - March 28, 2017 Category: Nursing Source Type: research

The Influence of β-Adrenergic Receptor Kinase-1 on Stroke-induced Immunodeficiency Syndrome
The objective was to quantify the influence of lymphocyte BARK-1 on stroke-induced immunodeficiency in AIS patients. Methods: A prospective clinical cohort study was conducted (N = 44). Measures included age, gender, race, risk factors for stroke, stroke severity, comorbidities, presence of infection, white blood cell counts and differential proportions, and lymphocyte BARK-1. Student t tests, effect sizes, and linear and logistic regressions were conducted to test the study objective. The study was approved by the Oregon Health & Science University Institutional Review Board. Results: There were significant changes ...
Source: Journal of Cardiovascular Nursing - June 12, 2018 Category: Nursing Tags: Feature Article/Online Only Source Type: research

E-057 Process Improvement in Door-to-Groin Puncture Times at a Comprehensive Stroke Center Shows a Trend Towards Reduced Mortality at 90 Days
ConclusionOur systematic process improvement initiative significantly reduced door-to-groin puncture times and showed a trend towards reduced mortality at 90 days. A multidisciplinary approach and ensuring hospital system investment are key to an effective process.DisclosuresY. Kayan: 2; C; Medtronic, Penumbra. J. Delgado Almandoz: 2; C; Medtronic, Penumbra. M. Young: None. J. Fease: None. J. Scholz: None. A. Milner: None. T. Hehr: None. M. Mulder: None. P. Roohani: None. R. Tarrel: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Kayan, Y., Delgado Almandoz, J., Young, M., Fease, J., Scholz, J., Milner, A., Hehr, T., Mulder, M., Roohani, P., Tarrel, R. Tags: Electronic poster abstracts Source Type: research

Blood test identifies risk of disease linked to stroke and dementia
A UCLA-led study has found that levels of six proteins in the blood can be used to gauge a person ’s risk for cerebral small vessel disease, or CSVD, a brain disease that affects an estimated 11 million older adults in the U.S. CSVD can lead to dementia and stroke, but currently it can only be diagnosed with an MRI scan of the brain.“The hope is that this will spawn a novel diagnostic test that clinicians can start to use as a quantitative measure of brain health in people who are at risk of developing cerebral small vessel disease,” said Dr. Jason Hinman, a UCLA assistant professor of neurology and lead author of t...
Source: UCLA Newsroom: Health Sciences - February 1, 2020 Category: Universities & Medical Training Source Type: news

Brain rewires itself after damage or injury, life scientists discover
When the brain's primary "learning center" is damaged, complex new neural circuits arise to compensate for the lost function, say life scientists from UCLA and Australia who have pinpointed the regions of the brain involved in creating those alternate pathways — often far from the damaged site.   The research, conducted by UCLA's Michael Fanselow and Moriel Zelikowsky in collaboration with Bryce Vissel, a group leader of the neuroscience research program at Sydney's Garvan Institute of Medical Research, appears this week in the early online edition of the journal Proceedings of the National Academy of Sciences. ...
Source: UCLA Newsroom: Health Sciences - May 15, 2013 Category: Universities & Medical Training Source Type: news

Prevention of central nervous system sequelae in sickle cell disease without evidence from randomized controlled trials: the case for a team-based learning collaborative.
Authors: DeBaun MR, King AA Abstract Since 1998, the National Institutes of Health has funded 5 randomized controlled trials (RCTs) for primary and secondary prevention of strokes in children with sickle cell anemia (SCA). In a systematic fashion, these trials have significantly advanced the care of children with SCA. In the absence of an RCT, clinicians are often compelled to make decisions at the bedside, based on experience, observational studies, and principles of hematology. We will provide an initial example that describes how a team-based, learning collaborative developed a multisite standard care protocol w...
Source: Hematology ASH Education Program - December 4, 2016 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Following nature ' s rules, researchers develop new methods for treating degenerative neurological disease
Following nature's rules, researchers develop new methods for treating degenerative neurological disease The University of Arizona has licensed the new class of drugs designed to penetrate the blood-brain barrier to startup Teleport Pharmaceuticals. Paul Tumarkin Tuesday Tech Launch Arizonateleport-web-crop.jpg Robin Polt (right) coaches undergraduate student Hannah Kuo Feinberg as she works on a glycopeptide project in Polt ’s lab. Paul Tumarkin/Tech Launch ArizonaHealthScience and TechnologyCollege of Medicine - TucsonCollege of ScienceDeterminationExpertsExplorationTech Launch Arizona Media contact(s)Paul...
Source: The University of Arizona: Health - July 26, 2022 Category: Universities & Medical Training Authors: mittank Source Type: research

Boosting 'cellular garbage disposal' can delay the aging process, UCLA biologists report
UCLA life scientists have identified a gene previously implicated in Parkinson's disease that can delay the onset of aging and extend the healthy life span of fruit flies. The research, they say, could have important implications for aging and disease in humans.   The gene, called parkin, serves at least two vital functions: It marks damaged proteins so that cells can discard them before they become toxic, and it is believed to play a key role in the removal of damaged mitochondria from cells.   "Aging is a major risk factor for the development and progression of many neurodegenerative diseases," said David Walke...
Source: UCLA Newsroom: Health Sciences - May 6, 2013 Category: Universities & Medical Training Source Type: news

First person - Alec Nickolls FIRST PERSON
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Alec Nickolls is first author on ‘Human embryoid bodies as a 3D tissue model of the extracellular matrix and α-dystroglycanopathies’, published in DMM. Alec conducted the research described in this article while a PhD student in Carsten Bönnemann's lab at National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. He is now a postdoctora...
Source: DMM Disease Models and Mechanisms - June 25, 2020 Category: Biomedical Science Tags: FIRST PERSON Source Type: research

Researchers find link between Parkinson ' s gene and vocal issues that could lead to earlier diagnosis
This study was supported in part by funds from the Parkinson ' s and Movement Disorder Foundation, the University of Arizona ' sAccelerate for Success Program andCore Facilities Pilot Program, and departmental startup funds. The research was also supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under award number R21NS123512. Medina ' s work was supported by a National Science Foundation Graduate Research Fellowship under National Science Foundation award number DGE-1746060, the University of Arizona ' s Initiative for Maximizing Student Development under Nationa...
Source: The University of Arizona: Health - May 2, 2022 Category: Universities & Medical Training Authors: mittank Source Type: research

When does life end? New organ donation strategy fuels debate
On a chilly holiday Monday in January 2020, a medical milestone passed largely unnoticed. In a New York City operating room, surgeons gently removed the heart from a 43-year-old man who had died and shuttled it steps away to a patient in desperate need of a new one. More than 3500 people in the United States receive a new heart each year. But this case was different—the first of its kind in the country. “It took us 6 months to prepare,” says Nader Moazami, surgical head of heart transplantation at New York University (NYU) Langone Health, where the operation took place. The run-up included oversight from an ethi...
Source: ScienceNOW - May 11, 2023 Category: Science Source Type: news