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Inclisiran: A New Strategy for LDL-C Lowering and Prevention of Atherosclerotic Cardiovascular Disease
Vasc Health Risk Manag. 2023 Jul 6;19:421-431. doi: 10.2147/VHRM.S338424. eCollection 2023.ABSTRACTMultiple lines of evidence confirm that the cumulative burden of low-density lipoprotein cholesterol (LDL-C) is causally related to the development of atherosclerotic cardiovascular disease (ASCVD). As such, lowering LDL-C is a central tenet in all ASCVD prevention guidelines, which recommend matching the intensity of LDL-C lowering with the absolute risk of the patient. Unfortunately, issues such as difficulty with long-term adherence to statin therapy and inability to achieve desired LDL-C thresholds with statins alone resu...
Source: Atherosclerosis - July 12, 2023 Category: Cardiology Authors: Michael S Albosta Jelani K Grant Pam Taub Roger S Blumenthal Seth S Martin Erin D Michos Source Type: research

Investigation of Combined Carotid Endarterectomy and Coronary Artery Bypass Graft Surgery Outcomes and Adverse Event Risk Factors in the Vascular Quality Initiative
CONCLUSIONS: Combined CEA and CABG provides excellent long-term mortality prevention in patients with co-existing severe coronary and carotid atherosclerosis. Simultaneous CEA and CABG provides equivalent stroke prevention and long-term survival to both a cohort of patients undergoing coronary revascularization within 5 years of CEA and patients undergoing isolated CEA or CABG in the literature. The two most impactful modifiable risk factors towards long-term stroke and mortality prevention for patients undergoing simultaneous CEA-CABG are patch placement at CEA site and adherence to statin medication therapy.PMID:37303074...
Source: Atherosclerosis - June 11, 2023 Category: Cardiology Authors: Ashley Penton Jonathan Lin Grant Kolde Matthew DeJong Matthew Blecha Source Type: research

Generalizability of the REDUCE-IT trial to South Asians with cardiovascular disease
CONCLUSIONS: A large proportion of high-intensity, statin-treated, high-risk patients with ASCVD and of self-reported SA ethnicity are eligible for IPE. These data have important translational implications for SAs who are at a disproportionately higher risk of CV morbidity and mortality.FUNDING: This study was funded by an unrestricted grant provided by HLS Therapeutics Inc, Canada.PMID:36630964 | DOI:10.1016/j.medj.2022.12.008
Source: Atherosclerosis - January 11, 2023 Category: Cardiology Authors: Aishwarya Krishnaraj Ehab Bakbak Hwee Teoh Deepak L Bhatt Adrian Quan Pankaj Puar Bhaavani Lambotharan Aathmika Kirubaharan Irene N Firoz Gus Meglis Bobby Yanagawa Basel Bari Rajaratnam Kirubaharan Ram Vijayaraghavan David A Hess Andrew M Demchuk G B John Source Type: research

Diagnosis, Phenotype, and Molecular Genetics of Congenital Analbuminemia
Conclusion Figure 4 shows that the 27 different molecular defects within the ALB so far reported to cause CAA are located in ten different exons (1, 3, 4, 5, 7, 8, 9, 10, 11, and 12) and in seven different introns (1, 2, 3, 6, 10, 11, and 12) (The Albumin Website, 2018; Caridi et al., 2019). Variations in the last two coding exons (13 and 14) would probably cause the presence of a circulating C-terminal variant of the protein and not CAA. The first twelve exons of ALB, with the exception of the two shortest, exons 2 and 6, were reported to contain at least one molecular defect resulting in CAA (The Albumin Website, 2018; ...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches
Conclusions In recent years, there have been many advances in the understanding of the molecular basis for vascular involvement in APS, but many areas need to be further investigated, in particular the association between altered genetic/epigenetic profiles, autoantibodies and clinical manifestations, and the effectiveness of new therapeutic strategies. It would be interesting to apply next generation sequencing technologies like RNA-Seq along with GWAS to screen both, the gene profile and the whole transcriptome of large cohorts of primary APS patients, in order to reveal the mutations/polymorphisms, post-transcriptiona...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Sex-Interacting mRNA- and miRNA-eQTLs and Their Implications in Gene Expression Regulation and Disease
This study is the first study to our knowledge that investigated sex-interacting eQTLs in miRNA, and the first study to use two stage regression to investigate ss-eQTLs. Although recent studies suggest that there exist genetic contributions to sexual dimorphisms in complex traits (Rawlik et al., 2016), at the gene expression level, we may not detect many sex-interacting eQTLs in a specific tissue. Increased sample sizes, and increased studies in more tissues may uncover more ss-eQTLs and increase our understanding of sexual dimorphism in gene regulation. Author Contributions JS and WY contributed to conception and design...
Source: Frontiers in Genetics - April 8, 2019 Category: Genetics & Stem Cells Source Type: research