• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Stroke and Ischemic Heart Disease With Enzyme-inducing Antiseizure Medications: Time to Change Prescribing Habits
Conclusions and Relevance: The hazard of incident cardiovascular disease is higher in those receiving eiASMs. The association is dose dependent and the absolute difference in hazard seems to reach clinical significance by approximately 10 years from first exposure.PMID:35444497 | PMC:PMC8988723 | DOI:10.1177/15357597211070392
Source: Epilepsy Currents - April 21, 2022 Category: Neurology Authors: David G Vossler Source Type: research

Antiepileptic Drug Prescribing for OEF/OIFVeterans with New-Onset Epilepsy: 2008-2010 (S59.004)
CONCLUSIONS: Our examination of prescribing patterns found that slightly over half of individuals with new epilepsy were treated using newer AEDs and 94% received monotherapy. Despite lack of FDA approval or recommendation by the AES, AAN or the ILAE for the use of levetiracetam monotherapy in the treatment of new onset epilepsy, levetiracetam monotherapy was the most common single medication prescribed. Moreover, nearly 40% of women in childbearing age received valproate or topiramate, which have been identified as teratogenic. Further research is needed to evaluate the quality of prescribing for women.Study Supported by:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pugh, M. J., Van Cott, A., Baca, C., Amuan, M. Tags: Epilepsy and Clinical Neurophysiology (EEG): Reproduction, Health Care Delivery, and Co-morbidities Source Type: research

Antiepileptic Drug Prescribing for OEF/OIFVeterans with New-Onset Epilepsy: 2008-2010 (I8-1.009)
CONCLUSIONS: Our examination of prescribing patterns found that slightly over half of individuals with new epilepsy were treated using newer AEDs and 94% received monotherapy. Despite lack of FDA approval or recommendation by the AES, AAN or the ILAE for the use of levetiracetam monotherapy in the treatment of new onset epilepsy, levetiracetam monotherapy was the most common single medication prescribed. Moreover, nearly 40% of women in childbearing age received valproate or topiramate, which have been identified as teratogenic. Further research is needed to evaluate the quality of prescribing for women.Study Supported by:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pugh, M. J., Van Cott, A., Baca, C., Amuan, M. Tags: Clinical Decision Making After the Dust Settles on Clinical Trials Poster Presentations Source Type: research

Mitochondrial Dysfunction in Migraine
Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and migraine: (1) Biochemical evidence: Abnormal mt function translates into high intracellular penetration of Ca2+, excessive production of free radicals, and deficient oxidative phosphorylation, which ultimately causes energy failure in neurons and astrocytes, thus triggering ...
Source: Seminars in Pediatric Neurology - September 1, 2013 Category: Neurology Authors: William R. Yorns, H. Huntley Hardison Source Type: research

Childhood and Adolescent Migraine Prevention (CHAMP) Study: A Double-Blinded, Placebo-Controlled, Comparative Effectiveness Study of Amitriptyline, Topiramate, and Placebo in the Prevention of Childhood and Adolescent Migraine.
CONCLUSIONS: The goal of the CHAMP study is to obtain level 1 evidence for the effectiveness of amitriptyline and topiramate in the prevention of migraine in children and adolescents. If this study proves to be positive, it will provide information to the practicing physician as how to best prevent migraine in children and adolescents and subsequently improve the disability and outcomes. PMID: 23594025 [PubMed - in process]
Source: Headache - May 1, 2013 Category: Neurology Authors: Hershey AD, Powers SW, Coffey CS, Eklund DD, Chamberlin LA, Korbee LL, CHAMP Study Group Tags: Headache Source Type: research

Childhood and Adolescent Migraine Prevention (CHAMP) Study: A Double‐Blinded, Placebo‐Controlled, Comparative Effectiveness Study of Amitriptyline, Topiramate, and Placebo in the Prevention of Childhood and Adolescent Migraine
ConclusionsThe goal of the CHAMP study is to obtain level 1 evidence for the effectiveness of amitriptyline and topiramate in the prevention of migraine in children and adolescents. If this study proves to be positive, it will provide information to the practicing physician as how to best prevent migraine in children and adolescents and subsequently improve the disability and outcomes.
Source: Headache: The Journal of Head and Face Pain - April 17, 2013 Category: Neurology Authors: Andrew D. Hershey, Scott W. Powers, Christopher S. Coffey, Dixie D. Eklund, Leigh Ann Chamberlin, Leslie L. Korbee, Tags: Protocols Source Type: research

Pages: 1  2  3  4  5  6  7  8