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Potential Drug Interactions in Terminally-Ill Cancer Patients, a Report from the Middle East
This study aims to evaluate the epidemiology of potential drug interactions in terminally-ill cancer patients receiving exclusively supportive care. In this cross-sectional study, during a 6-month follow-up, we considered the medical record of terminally-ill cancer patients referred to palliative care at the cancer center in Isfahan, Iran. Potential drug-drug interactions (DDIs) were assessed by Lexi-Interact ver.1.1 online software. During the study period, 133 terminally-ill cancer patients were recruited. We detected 1678 DDIs with moderate or major severity levels. Among them, 330, 219, 32, 1075, and 51 interactions we...
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Hamed Mahzoni Erfan Naghsh Mehran Sharifi Ayda Moghaddas Mahnaz Momenzadeh Azadeh Moghaddas Source Type: research

Naldemedine-induced opioid withdrawal with restlessness as the predominant symptom in a palliative care setting
We report a terminally ill cancer patient who was diagnosed with opioid withdrawal syndrome (OWS) based on symptoms centered around restlessness and sweating that developed 43 days after administration of naldemedine for OIC.RESULTS: The patient was a 78-year-old woman who was diagnosed with stage IVB uterine sarcoma in October, 1 year prior to her visit to our clinic, and underwent chemotherapy after surgery, but the disease became progressive. Thereafter, metastasis to the fourth thoracic vertebrae (Th4) was identified, and loxoprofen and acetaminophen were started for pain at the metastatic site. Oxycodone hydrochloride...
Source: Palliative and Supportive Care - June 23, 2023 Category: Palliative Care Authors: Ryota Sato Mayumi Ishida Nozomu Uchida Takehiko Sakimoto Takefumi Yamaguchi Yoshitaka Ooya Takao Takahashi Hideki Onishi Source Type: research

Y-site injection physical compatibility of remdesivir with select intravenous drugs used in palliative care and for treating coronavirus disease 2019
CONCLUSIONS: The drugs tested in this study show Y-site physical compatibility with remdesivir.PMID:37271548 | DOI:10.1272/jnms.JNMS.2023_90-508
Source: Journal of Nippon Medical School - June 4, 2023 Category: Universities & Medical Training Authors: Masayoshi Kondo Mai Genpei Kei Watanabe Masato Yoshida Naoya Tagui Shouhei Fukao Kazutoshi Sugaya Hisamitsu Takase Source Type: research

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