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TWiV 1020: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong, safety, immunogenicity and protection of heterol...
Source: This Week in Virology - MP3 Edition - July 1, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Bmal1 and Gut-lung axis in SARS-CoV-2 infection: New insight into the effects of melatonin on COVID-19 patients?
Biomed Pharmacother. 2023 Jan 23;164:114291. doi: 10.1016/j.biopha.2023.114291. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19), is known as one of the most known challenge worldwide. Numerous studies have tried to introduce different mechanisms involved in the pathophysiology of COVID-19 and efforts in this field are also ongoing. The presence of SARS-CoV-2 RNA in feces of COVID-19 patients along with a variety of gastrointestinal symptoms may show a significant association between gut microbiota and SARS-CoV-2 infection. However, the exact mechanism indicating how SARS-CoV-2 and gut flora influence each...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 31, 2023 Category: Drugs & Pharmacology Authors: Mohammad Rafi Khezri Reza Varzandeh Morteza Ghasemnejad-Berenji Source Type: research

Role of Supplements in the Management of COVID-19 - A Comprehensive Review
Infect Disord Drug Targets. 2023 Mar 10. doi: 10.2174/1871526523666230310094646. Online ahead of print.ABSTRACTCoronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) and patients with COVID-19 may be treated primarily with SARS CoV-2-targeting drugs and the therapeutic agents assisting in the management of COVID-19 complications. This review focuses on the supplements like vitamins, minerals, herbal constituents, and others that help prevent or manage negative outcomes among COVID-19 patients. The literature was searched in databases such as Medline/PubMed Central/...
Source: Infectious Disorders Drug Targets - March 10, 2023 Category: Infectious Diseases Authors: Rajkapoor Balasubramanian Naina Mohamed Pakkir Maideen Sudha Muthusamy Sambathkumar Ramanathan Mohamed Harsath Jahir Hussain Source Type: research

Development of indolealkylamine derivatives as potential multi-target agents for COVID-19 treatment
In conclusion, we provide a proof-of-concept for the successful design of multi-target compounds based on the tryptamine scaffold. Optimization of these preliminary hit compounds could potentially provide drug candidates to treat COVID-19 and other coronavirus diseases.PMID:36724633 | DOI:10.1016/j.ejmech.2023.115152
Source: European Journal of Medicinal Chemistry - February 1, 2023 Category: Chemistry Authors: Jyoti Chauhan Erika Cecon Nedjma Labani Florence Gbahou Fernando Real Morgane Bomsel Kshatresh Dutta Dubey Ranajit Das Julie Dam Ralf Jockers Subhabrata Sen Source Type: research

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