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Maternal melatonin supplementation shapes gut microbiota and protects against inflammation in early life
CONCLUSION: This study suggests that maternal melatonin supplementation can shape the gut microbiota and metabolism of offspring under normal physiological conditions and protect them against LPS-induced inflammation in early life.PMID:37257272 | DOI:10.1016/j.intimp.2023.110359
Source: International Immunopharmacology - May 31, 2023 Category: Allergy & Immunology Authors: Fei Li Jiahao Lai Fei Ma Yao Cai Sitao Li Zhoushan Feng Zhendong Lu Xiao Liu Qiong Ke Hu Hao Xin Xiao Source Type: research

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The effects of daytime melatonin ingestion on arousal and vigilance vanish after sub-maximal exercise: a pilot study
CONCLUSIONS: The negative effects of melatonin ingestion on vigilance and arousal vanished after a 45 min of submaximal exercise. The hypnotic effect of melatonin observed in the pre-exercise dissipated in the post-exercise period, possibly due to the significant elevation of Tre, HR, and cortisol at the end of submaximal exercise.PMID:36111906 | DOI:10.26355/eurrev_202209_29622
Source: Pharmacological Reviews - September 16, 2022 Category: Drugs & Pharmacology Authors: A Souissi M A Farjallah O Gaied Chortane I Dergaa M A Mejri N Gaamouri N Souissi N Souissi K Chamari K Weiss H Ben Saad A Ghram B Knechtle Source Type: research

Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Common Sleep Disorders in Children
Am Fam Physician. 2022 Feb 1;105(2):168-176.ABSTRACTChildhood sleep disorders can disrupt family dynamics and cause cognitive and behavior problems. Early recognition and management can prevent these complications. Behavior subtypes of childhood insomnias affect 10% to 30% of children and result from inconsistent parental limit-setting and improper sleep-onset association. Behavior insomnias are treated using extinction techniques and parent education. Hypnotic medications are not recommended. Obstructive sleep apnea affects 1% to 5% of children. Polysomnography is required to diagnose obstructive sleep apnea; history and ...
Source: American Family Physician - February 15, 2022 Category: Primary Care Authors: Prajakta Deshpande Betzy Salcedo Cynthia Haq Source Type: research

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