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Intra-Operative Adjunctive Magnesium Sulfate in Pain Management of Total Knee Arthroplasty; a Systematic Review and Meta-analysis
CONCLUSION: This study presents evidence at low to moderate levels supporting the use of intra-operative adjunctive magnesium sulfate in TKA for improved pain management and reduced opioid consumption. However, further research is needed to address the heterogeneity and to explore optimal dosing regimens and routes of administration to maximize the benefits of magnesium sulfate in TKA.PMID:37671273 | PMC:PMC10475748 | DOI:10.22037/aaem.v11i1.2058
Source: Accident and Emergency Nursing - September 6, 2023 Category: Emergency Medicine Authors: Amirali Azimi Fatemeh-Sadat Tabatabaei Amirfarbod Azimi Hamid Mazloom Mohammad Mehdi Foruzanfar Nastaran Sadat Mahdavi Source Type: research

Postoperative analgesia for complex spinal surgery
Purpose of review Complex spinal surgery is associated with significant postoperative pain. The purpose of this paper is to review recent literature on postoperative pain management in adult and adolescent patients having complex spinal surgery. Recent findings We conducted a literature search using the Medline database for relevant publications from 2020 to 2022 on postoperative pain after complex spinal surgery. Although opioids remain the mainstay to manage pain after complex spinal surgery, they are associated with adverse effects. Multimodal analgesia may be used to reduce these adverse effects by combining...
Source: Current Opinion in Anaesthesiology - September 7, 2022 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Anthony R. Absalom Source Type: research

The Effect of Erector Spinae Plane Block With and Without Addition of Magnesium on Relief of Pain from Post-herpetic Neuralgia
CONCLUSION: ESPB with or without adding magnesium sulphate is an effective pain management tool for cases of PHN. It leads to a significant decrease in pain score and analgesic requirements.PMID:35901476
Source: Pain Physician - July 28, 2022 Category: Anesthesiology Authors: Sameh Abdelhalik Ahmed Amr Ahmed Magdy Mohammad Ali Abdullah Amr Arafa Albadry Source Type: research

Case Report: Posterolateral Epidural Supra-C2-Root Approach (PESCA) for Biopsy of a Retro-Odontoid Lesions in Same Sitting After Occipitocervical Fixation and Decompression in a Case of Crowned Dens Syndrome With Brainstem Compression and Displacement
CONCLUSIONS: This study demonstrates that PESCA can be used to obtain tissue for pathological analysis in one surgical sitting after fusion and decompression and that fusion, decompression, and PESCA (in the same session) together with subsequent conservative management could be a good alternative for the treatment of CDS.PMID:35558389 | PMC:PMC9086508 | DOI:10.3389/fsurg.2022.797495
Source: Hand Surgery - May 13, 2022 Category: Surgery Authors: Patrick Haas Till-Karsten Hauser Kosmas Kandilaris Marco Skardelly Marcos Tatagiba Sasan Darius Adib Source Type: research

Utilization of Magnesium for the Treatment of Chronic Pain
CONCLUSIONS: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain.PMID:34221945 | PMC:PMC8236839 | DOI:10.5812/aapm.112348
Source: Pain Physician - July 5, 2021 Category: Anesthesiology Authors: Ivan Urits Jai Won Jung Ariunzaya Amgalan Luc Fortier Anthony Anya Brendan Wesp Vwaire Orhurhu Elyse M Cornett Alan D Kaye Farnad Imani Giustino Varrassi Henry Liu Omar Viswanath Source Type: research

Pharmacological Methods of Postoperative Pain Management After Laparoscopic Cholecystectomy: A Review of Meta-analyses
Conclusions: Very low to low–quality evidence indicated that pharmacological agents, such as nonsteroidal anti-inflammatory drugs, lidocaine, parecoxib, nefopam, dexamethasone, and magnesium sulfate, could decrease pain intensity in patients undergoing LC. Moreover, moderate to high–quality evidence showed that intravenous infusion of ketamine and opioids, as well as pregabalin, was effective in pain control. Further, robust clinical trials are needed with several arms (eg, pharmacological agents) to compare the efficacy and safety of analgesics under similar clinical conditions and to find optimal regimens for pai...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - December 1, 2020 Category: Surgery Tags: Review Articles Source Type: research

The Evidence for the Role of Nutraceuticals in the Management of Pediatric Migraine: a Review
AbstractPurpose of ReviewNutraceuticals are a form of complementary and alternative medicine that is commonly used by children and adolescents with migraine. In this review, observational studies, randomized controlled trials, systematic reviews, and meta-analyses on the efficacy and safety of single compound nutraceuticals for the management of migraine in children and adolescents were identified through a literature search of MEDLINE, Embase, and EBM Reviews —Cochrane Central Register of Controlled Trials.Recent FindingsTwenty-one studies were reviewed, of which 11 were observational studies, 7 were randomized controll...
Source: Current Pain and Headache Reports - April 4, 2018 Category: Neurology Source Type: research

Epidural therapy for the treatment of severe pre-eclampsia in non labouring women.
CONCLUSIONS: Currently, there is insufficient evidence from randomised controlled trials to evaluate the effectiveness, safety or cost of using epidural therapy for treating severe pre-eclampsia in non-labouring women.High-quality randomised controlled trials are needed to evaluate the use of epidural agents as therapy for treatment of severe pre-eclampsia. The rationale for the use of epidural is well-founded. However there is insufficient evidence from randomised controlled trials to show that the effect of epidural translates into improved maternal and fetal outcomes. Thus, there is a need for larger, well-designed stud...
Source: Cochrane Database of Systematic Reviews - November 28, 2017 Category: General Medicine Authors: Ray A, Ray S Tags: Cochrane Database Syst Rev Source Type: research

What Causes Hypercalcemia?
Discussion Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here. Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium. Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydra...
Source: PediatricEducation.org - March 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news