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Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect How to Construct Measures of Biological Age A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome Intestinal Barrier Dysfunction as a Feature of Aging in Many Species NAFLD as an Age-Related Condition Towards Sensory Hair Cell Regeneration in the Inner Ear Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Mitochondrial dynamics when mitochondrial toxic chemicals exposed in 3D cultured mouse embryonic stem cell
Toxicol Res. 2022 Dec 13;39(2):239-249. doi: 10.1007/s43188-022-00161-1. eCollection 2023 Apr.ABSTRACTMitochondria need to use considerable energy for the intracellular organelles that produce ATP. They are abundant in the cells of organs, such as muscles, liver, and kidneys. The heart, which requires a lot of energy, is also rich in mitochondria. Mitochondrial damage can induce cell death. Doxorubicin, acetaminophen, valproic acid, amiodarone, and hydroxytamoxifen are representative substances that induce mitochondrial damage. On the other hand, the effects of this substance on the progress of cardiomyocyte-differentiatin...
Source: Cell Research - April 3, 2023 Category: Cytology Authors: Changhwan Ahn SunHwa Jeong Eui-Bae Jeung Source Type: research

Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts
Arch Toxicol. 2022 Sep 4. doi: 10.1007/s00204-022-03372-5. Online ahead of print.ABSTRACTThe persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in the United States, despite the availability of N-acetylcysteine, illustrates the clinical relevance of additional therapeutic approaches. While human mesenchymal stem cells (MSCs) have shown protection in mouse models of liver injury, the MSCs used are generally not cleared for human use and it is unclear whether these effects are due to xenotransplantation. Here w...
Source: Archives of Toxicology - September 4, 2022 Category: Toxicology Authors: David S Umbaugh Rupal P Soder Nga T Nguyen Olamide Adelusi Dakota R Robarts Ben Woolbright Luqi Duan Sunil Abhyankar Buddhadeb Dawn Udayan Apte Hartmut Jaeschke Anup Ramachandran Source Type: research

Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway
CONCLUSIONS: Activation of Notch2 is required for the ability of MSCs to reduce the severity of APAP-induced liver damage in mice. Our findings underscore a novel molecular insights into MSCs-mediated immunomodulation by activating Notch2/COX2/AMPK/SIRT1 pathway and thus provide a new strategy for the treatment of liver inflammatory diseases.PMID:35842731 | DOI:10.1186/s13287-022-02999-6
Source: Cell Research - July 16, 2022 Category: Cytology Authors: Mengxue Yu Min Zhou Jiahui Li Ruobin Zong Yufei Yan Liangyi Kong Qiang Zhu Changyong Li Source Type: research

First Human Report of Relief of Lumbar and Cervical Discogenic and Arthritic Back Pain after Epidural and Facet Joint Mesenchymal Stem Cell Injection
CONCLUSION: We have demonstrated for the first time that MSC injection into the lumbar facet joints and epidural space results in significant improvement of lower back pain and additionally has the capability to improve symptoms in other spinal regions without engendering the risks associated with intradiscal injections or epidural use of corticosteroids.PMID:35762554 | DOI:10.2174/1574888X17666220628123115
Source: Current Stem Cell Research and Therapy - June 28, 2022 Category: Stem Cells Authors: Joshua Sharan Amir Barmada Chadwick Prodromos Kenneth Candido Source Type: research

The spatiotemporal program of zonal liver regeneration following acute injury
Cell Stem Cell. 2022 Jun 2;29(6):973-989.e10. doi: 10.1016/j.stem.2022.04.008.ABSTRACTThe liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-cell approaches are necessary to study this process, given the spatial heterogeneity of liver cell types. Here, we use spatially resolved single-cell RNA sequencing (scRNA-seq) to study the dynamics of mouse liver regeneration after acute acetaminophen (APAP) intoxication. We find that hepatocytes proliferate throughout the liver lobule, creating the mitotic pressure required to repopulate the necrotic pericentral zone rapidly. A subset of hepato...
Source: Cell Stem Cell - June 6, 2022 Category: Stem Cells Authors: Shani Ben-Moshe Tamar Veg Rita Manco Stav Dan Delfina Papinutti Aviezer Lifshitz Aleksandra A Kolodziejczyk Keren Bahar Halpern Eran Elinav Shalev Itzkovitz Source Type: research

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