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Tangeretin and 4'-demethyltangeretin prevent damage to mouse hepatocytes from oxidative stress by activating the Nrf2-related antioxidant pathway via an epigenetic mechanism
In this study we examined the effects of tangeretin (TAN), a common citrus PMF, and its metabolite 4'-demethyltangeretin (4'-OH-TAN) on activation of the Nrf2 antioxidant system in mouse AML-12 hepatocytes through regulation by epigenetic mechanisms. The ability of TAN and 4'-OH-TAN to inhibit APAP-induced hepatotoxicity was also evaluated. The results showed that TAN and 4'-OH-TAN significantly increased the mRNA and protein levels of Nrf2 and Nrf2-mediated antioxidant and detoxifying enzymes (UGT1A, HO-1, and NQO1) in AML-12 cells. TAN and 4'-OH-TAN also suppressed protein expression of histone deacetylases (HDACs) and D...
Source: Chemico-Biological Interactions - July 30, 2023 Category: Molecular Biology Authors: Zheng-Yuan Su Jen-Chun Chien Yen-Chen Tung Tien-Yuan Wu Jie-An Liao Guor-Jien Wei Source Type: research

Dose-dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets
In conclusion, platelets from healthy donors represents a population of cells easily available, which can be routinely used in studies assessing mitochondrial drug toxicity. Whether these results can be recapitulated in patients treated with these medications is worth further investigation as potential peripheral biomarker of drug overdose.PMID:37486451 | DOI:10.1007/s11010-023-04814-z
Source: Molecular Medicine - July 24, 2023 Category: Molecular Biology Authors: Alina Maria Be ţiu Rodica Lighezan Vlad Florian Avram Danina Mirela Muntean Eskil Elm ér Lucian Petrescu Source Type: research

Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3 β phosphorylation and mitochondrial translocation
Exp Mol Med. 2023 Jun 1. doi: 10.1038/s12276-023-01009-w. Online ahead of print.ABSTRACTThe signaling pathways governing acetaminophen (APAP)-induced liver injury have been extensively studied. However, little is known about the ubiquitin-modifying enzymes needed for the regulation of APAP-induced liver injury. Here, we examined whether the Pellino3 protein, which has E3 ligase activity, is needed for APAP-induced liver injury and subsequently explored its molecular mechanism. Whole-body Peli3-/- knockout (KO) and adenovirus-mediated Peli3 knockdown (KD) mice showed reduced levels of centrilobular cell death, infiltration ...
Source: Molecular Medicine - May 31, 2023 Category: Molecular Biology Authors: Jaewon Lee Jihoon Ha Jun-Hyeong Kim Dongyeob Seo Minbeom Kim Yerin Lee Seong Shil Park Dahee Choi Jin Seok Park Young Jae Lee Siyoung Yang Kyung-Min Yang Su Myung Jung Suntaek Hong Seung-Hoi Koo Yong-Soo Bae Seong-Jin Kim Seok Hee Park Source Type: research

Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
Curr Issues Mol Biol. 2023 May 17;45(5):4389-4399. doi: 10.3390/cimb45050279.ABSTRACTAcetaminophen (APAP) overdose can cause severe liver damage, but therapeutic options are limited. Apamin is a natural peptide present in bee venom and has antioxidant and anti-inflammatory properties. Accumulating evidence suggests that apamin has favorable actions in rodent models of inflammatory disorders. Here, we examined the effect of apamin on APAP-evoked hepatotoxicity. Intraperitoneal administration of apamin (0.1 mg/kg) alleviated histological abnormalities and reduced serum levels of liver enzymes in mice injected with APAP. Apam...
Source: Current Issues in Molecular Biology - May 26, 2023 Category: Molecular Biology Authors: Hyo-Jeong Jang Jaechan Leem Gyun Moo Kim Source Type: research

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