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Drug: Lithium

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Total 72 results found since Jan 2013.

Phosphorylation of PI3K/Akt at Thr308, but not MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Exp Neurol. 2022 Feb 2:113996. doi: 10.1016/j.expneurol.2022.113996. Online ahead of print.ABSTRACTLithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its modulatory effect on GSK pathway. Therefore, we initially analyzed the dose-dependent effects of lithium on neurological deficits, infarct volume, brain edema and blood-brain barrier integrity, along with neuronal injury and survival in mice subjected to focal cerebral ischemia. Thereafter, we investigated the in...
Source: Experimental Neurology - February 5, 2022 Category: Neurology Authors: Nilay Ates Aysun Caglayan Zeynep Balcikanli Elif Sertel Mustafa Caglar Beker Pelin Dilsiz Ahmet Burak Caglayan S üleyman Celik Muhammed Furkan Dasdelen Berrak Caglayan T ürkan Yigitbasi Hanefi Ozbek Thorsten Roland Doeppner Dirk Matthias Hermann Ertugru Source Type: research

4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation.
Abstract Hypoxia is an important cause of brain injury in ischemic stroke. It is known that endoplasmic reticulum (ER) stress is an important determinant of cell survival or death during hypoxia. However, the signaling pathways and molecular mechanisms involved remain to be studied in more detail. To investigate whether inhibition of ER stress promotes neuroprotection pathways, we applied an in vitro oxygen-glucose deprivation (OGD) followed by reoxygenation model of human SK-N-MC neuronal cell cultures in this study. Our results showed that neuronal cell death was induced in this model during the OGD reoxygenatio...
Source: Cellular and Molecular Neurobiology - March 17, 2015 Category: Cytology Authors: Tung WF, Chen WJ, Hung HC, Liu GY, Tung JN, Huang CC, Lin CL Tags: Cell Mol Neurobiol Source Type: research

Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/ β-catenin signaling in mice.
Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/β-catenin signaling in mice. Neuropharmacology. 2021 Jan 29;:108474 Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Abstract Although upregulation of endothelial Wnt/β-catenin signaling may be used to treat blood-brain barrier (BBB) breakdown caused by cerebral ischemia/reperfusion injury, no agents based on this mechanism are available clinically. Lithium, a medication used for treating bipolar mood disorders, upregulates Wnt/β-...
Source: Neuropharmacology - January 29, 2021 Category: Drugs & Pharmacology Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Tags: Neuropharmacology Source Type: research

Lithium chloride promotes neural functional recovery after local cerebral ischemia injury in rats through Wnt signaling pathway activation
Folia Morphol (Warsz). 2022 Aug 2. doi: 10.5603/FM.a2022.0068. Online ahead of print.ABSTRACTLithium chloride (LiCl) has a significant neuroprotective effect in cerebral ischemia. However, to date, there is a paucity of evidence on the role of LiCl in neural restoration after brain ischemia and the signaling pathways involved remain unclear. Therefore, to address this gap, the middle cerebral artery occlusion (MCAO) rat model was used to simulate human ischemia stroke. Male SD rats were given MCAO for 90 min followed by reperfusion, and Dickkopf-1(DKK1, 5.0 μg/kg) was administered half an hour before MCAO. Rats were then ...
Source: Folia Morphologica - August 2, 2022 Category: Anatomy Authors: Z Junde L Tingting Z Lu C Shan Y Dan Source Type: research