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Drug: Lithium
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Total 26 results found since Jan 2013.
Major U.S. geological survey aims to uncover minerals critical for batteries and microchips
From the air, Maine is a uniform sea of green: Forests cover 90% of the state. But beneath the foliage and the dirt lies an array of geological terrains that is far more diverse, built from the relics of volcanic islands that collided with North America hundreds of millions of years ago.
Two years ago, sensor-laden aircraft began to survey these geochemically rich terrains for precious minerals. Researchers spotted an anomalous signal streaming out of Pennington Mountain, 50 kilometers from the Canadian border. State geologists bushwhacked through the paper mill–bound pine forests, taking rock samples. They
event...
Source: Science of Aging Knowledge Environment - June 1, 2023 Category: Geriatrics Source Type: research
Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is.
Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes?
https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/
Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cyclic estrogen and progesterone during instrumental acquisition contributes to habit formation in female rats
Horm Behav. 2022 Apr 8;142:105172. doi: 10.1016/j.yhbeh.2022.105172. Online ahead of print.ABSTRACTHabit formation is thought to involve two parallel processes that are mediated by distinct neural substates: one that suppresses goal-directed behavior, and one that facilitates stimulus-response (S-R) learning, which underscores habitual behavior. In previous studies we showed that habitual responding emerges early during instrumental training in gonadally-intact female, compared to male, rats. The present study aimed to determine the role of ovarian hormones during instrumental acquisition in the transition from goal-direct...
Source: Hormones and Behavior - April 11, 2022 Category: Endocrinology Authors: Hannah L Schoenberg Gillian P Bremer Francesca Carasi-Schwartz Sarah VonDoepp Christian Arnsten Allison M J Anacker Donna J Toufexis Source Type: research
Fight Aging! Newsletter, February 28th 2022
In conclusion, as BMI and waist circumference are related to elevations of immune markers in the IL-6 pathway, chronic inflammation might be an important mediator of the relationship between BMI and frailty.
Fat Tissue Becomes Dysfunctional with Age as Mitochondria Falter
https://www.fightaging.org/archives/2022/02/fat-tissue-becomes-dysfunctional-with-age-as-mitochondria-falter/
Mitochondria are effectively power plants, hundreds of them working in every cell to produce chemical energy store molecules to power cellular processes. Mitochondrial function declines with age, unfortunately, for underlying re...
Source: Fight Aging! - February 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Improved battery cycle life prediction using a hybrid data-driven model incorporating linear support vector regression and Gaussian process regression
In this study, two hybrid data-driven models, incorporating a traditional linear support vector regression (LSVR) and a Gaussian process regression (GPR), were developed to estimate battery life-time at an early stage, before more severe capacity fading, utilizing a data set of 124 battery cells with lifetimes ranging from 150 to 2300 cycles. Two type of hybrid models, here denoted as A and B, were proposed. For each of the models, we achieved 1.1 % (A) and 1.4 % (B) training error, and similarly, 8.3 % (A) and 8.2 % (B) test error. The two key advantages are that the error percentage is kept below 10\% and that very low e...
Source: Chemphyschem - January 25, 2022 Category: Chemistry Authors: Mohammad Alipour Shiva Sander Tavallaey Anna M Andersson Daniel Brandell Source Type: research
Dopamine sensitization by methamphetamine treatment prior to instrumental training delays the transition into habit in female rats
Behav Brain Res. 2021 Oct 20:113636. doi: 10.1016/j.bbr.2021.113636. Online ahead of print.ABSTRACTEarly in instrumental learning, behavior is goal-directed and sensitive to changes in the value of the instrumental outcome. With sufficient repetition, responding becomes insensitive to changes in outcome value, or habitual. We have previously found that females transition into habit over a distinct range of training from 120 to 160 reinforced responses. This low level of instrumental training is markedly less than what has been shown to support habitual responding in male rats. To begin to investigate the early development ...
Source: Brain Research - October 23, 2021 Category: Neurology Authors: Hannah L Schoenberg Charlotte Evans Lauren Bausch Abigail Wootton Ari Kirshenbaum Donna J Toufexis Source Type: research
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Quantitative analysis of lithium in brine by laser-induced breakdown spectroscopy based on convolutional neural network
In this study, a simple and effective method for accurate determination of lithium in brine samples was developed by the combination of laser induced breakdown spectroscopy (LIBS) and convolutional neural network (CNN). Our results clearly demonstrate that the use of CNN could efficiently overcome the complex matrix effects, and thus allows for on-site Li quantitative determination in brine samples by LIBS. Specifically, two CNN models with different input data (M-CNN with matrix emission lines, and DP-CNN with double Li lines) were constructed based on the primary matrix features on spectrum and Boltzmann equation, respec...
Source: Analytica Chimica Acta - September 6, 2021 Category: Chemistry Authors: Pengju Xing Junhang Dong Peiwen Yu Hongtao Zheng Xing Liu Shenghong Hu Zhenli Zhu Source Type: research
