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Drug: Insulin
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Total 212 results found since Jan 2013.
Spontaneous baroreflex sensitivity is attenuated in male UCD-type 2 diabetes mellitus rats: A link between metabolic and autonomic dysfunction
This study aimed to investigate the role of visceral fat and adiponectin, the most abundant cytokine produced by adipocytes, on baroreflex dysfunction in T2DM rats. Experiments were performed in adult male UCD-T2DM rats assigned to the following experimental groups (n = 6 in each): prediabetic (Pre), diabetes-onset (T0), 4 weeks after onset (T4), and 12 weeks after onset (T12). Age-matched healthy Sprague-Dawley rats were used as controls. Rats were anesthetized and blood pressure was directly measured on a beat-to-beat basis to assess spontaneous baroreflex sensitivity (BRS) using the sequence technique. Dual-energy X-ray...
Source: Autonomic Neuroscience - September 1, 2023 Category: Neuroscience Authors: Milena Samora Yu Huo Richard K McCuller Suchit Chidurala Kimber L Stanhope Peter J Havel Audrey J Stone Michelle L Harrison Source Type: research
The role of sex in the relationship between fasting adipokines levels, maximal fat oxidation during exercise, and insulin resistance in young adults with excess adiposity
CONCLUSION: Insulin resistance was similar between sexes regardless of superior levels of adipokines and MFO during exercise in women. Therefore, adiponectin and leptin may regulate glucose homeostasis without altering whole body fat oxidation rate during exercise.PMID:37598975 | DOI:10.1016/j.bcp.2023.115757
Source: Biochemical Pharmacology - August 20, 2023 Category: Drugs & Pharmacology Authors: Isaac A Ch ávez-Guevara Francisco J Amaro-Gahete Francisco J Osuna-Prieto Idoia Labayen Concepcion M Aguilera Jonatan R Ruiz Source Type: research
Complementary effects of dapagliflozin and lobeglitazone on metabolism in a diet-induced obese mouse model
We examined the complementary effects of dapagliflozin, an SGLT2 inhibitor, and lobeglitazone, a thiazolidinedione, in high-fat diet (HFD)-induced obese mice. We treated HFD-induced obese mice with vehicle, dapagliflozin, lobeglitazone, and their combination for 12 weeks. Oral glucose tolerance and insulin tolerance tests were performed after 12-week treatment, and body composition was measured by dual-energy X-ray absorptiometry before and after treatment. We analyzed oxygen consumption rate (OCR) using 3T3-L1 cells after treatment of β-hydroxybutyrate and/or lobeglitazone. Treatment with a combination of dapagliflozin a...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Yun Kyung Lee Tae Jung Oh Ji In Lee Bo Yoon Choi Hyen Chung Cho Hak Chul Jang Sung Hee Choi Source Type: research
Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial
CONCLUSIONS: The use of berberine had no adverse events, supporting its use as a natural alternative to pharmacological therapies in the case of IFG.PMID:37522683 | DOI:10.26355/eurrev_202307_33142
Source: Pharmacological Reviews - July 31, 2023 Category: Drugs & Pharmacology Authors: M Rondanelli C Gasparri G Petrangolini P Allegrini D Avenoso T Fazia L Bernardinelli G Peroni Z Patelli F Mansueto A Tartara A Cavioni A Riva Source Type: research
The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy
CONCLUSIONS: Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.PMID:37368517 | DOI:10.1002/oby.23773
Source: Obesity - June 27, 2023 Category: Eating Disorders & Weight Management Authors: Michelle D Pang Jacco J A J Bastings Yvonne M H Op den Kamp-Bruls Joanne A Harrold Louise Kj ølbaek Jason C G Halford Tanja C M Adam Anne Raben Vera B Schrauwen-Hinderling Gijs H Goossens Ellen E Blaak Source Type: research
