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Specialty: General Medicine
Drug: Insulin

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Total 49 results found since Jan 2013.

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack.
CONCLUSIONS: PPAR-γ agonists were demonstrated to reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and improve insulin sensitivity and the stabilisation of carotid plaques. There is evidence of limited quality that they are well-tolerated. However, the conclusions should be interpreted with caution considering the small number and the quality of the included studies. In future, well-designed, double-blind RCTs with large samples are required to test the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular ev...
Source: Cochrane Database of Systematic Reviews - January 8, 2014 Category: Journals (General) Authors: Liu J, Wang LN Tags: Cochrane Database Syst Rev Source Type: research

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack.
CONCLUSIONS: Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular...
Source: Cochrane Database of Systematic Reviews - December 2, 2017 Category: General Medicine Authors: Liu J, Wang LN Tags: Cochrane Database Syst Rev Source Type: research

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
CONCLUSIONS: Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular...
Source: Cochrane Database of Systematic Reviews - January 10, 2023 Category: General Medicine Authors: Jia Liu Lu-Ning Wang Source Type: research

Insulin for glycaemic control in acute ischaemic stroke.
CONCLUSIONS: After updating the results of our previous review, we found that the administration of intravenous insulin with the objective of maintaining serum glucose within a specific range in the first hours of acute ischaemic stroke does not provide benefit in terms of functional outcome, death, or improvement in final neurological deficit and significantly increased the number of hypoglycaemic episodes. Specifically, those people whose glucose levels were maintained within a tighter range with intravenous insulin experienced a greater risk of symptomatic and asymptomatic hypoglycaemia than those people in the control ...
Source: Cochrane Database of Systematic Reviews - January 23, 2014 Category: Journals (General) Authors: Bellolio MF, Gilmore RM, Ganti L Tags: Cochrane Database Syst Rev Source Type: research

Dynamic derangement in amino acid profile during and after a stroke-like episode in adult-onset mitochondrial disease: a case report
ConclusionsGrowth differentiation factor-15 can be used not only for the diagnosis of mitochondrial disease, but as an indicator of its acute exacerbation. A stroke-like episode of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes reflects a drastic derangement of multiple amino acids. The involvement of aspartic acid in the episodes should be explored in future studies.
Source: Journal of Medical Case Reports - October 20, 2019 Category: General Medicine Source Type: research

The effect of covariate adjustment for baseline severity in acute stroke clinical trials with responder analysis outcomes
Conclusions: Our results suggest that, under the given treatment effect scenarios, the decision whether or not to adjust for baseline severity when using a responder analysis outcome should be guided by the needs of the study, as type I error rates and power do not appear to vary largely between the methods. These findings are applicable to stroke trials which use the mRS for the primary outcome, but also provide a broader insight into the analysis of binary outcomes that are defined based on baseline prognostic variables.Trial registration: This research is part of the Stroke Hyperglycemia Insulin Network Effort (SHINE) t...
Source: Trials - April 11, 2013 Category: Journals (General) Authors: Kyra GarofoloSharon YeattsViswanathan RamakrishnanEdward JauchKaren JohnstonValerie Durkalski Source Type: research

Physical fitness training in Subacute Stroke (PHYS-STROKE) - study protocol for a randomised controlled trial
DiscussionThe goal of this endpoint-blinded, phase III randomised controlled trial is to provide evidence to guide post-stroke physical fitness-based rehabilitation programmes, and to elucidate the mechanisms underlying this intervention.Trial registration: Registered in ClinicalTrials.gov with the Identifier NCT01953549.
Source: Trials - February 3, 2014 Category: Journals (General) Authors: Agnes FlöelCordula WernerUlrike GrittnerStefan HesseMichael JöbgesJanet KnaussMichael SeifertElisabeth Steinhagen-ThiessenMehmet GövercinChristian DohleWolfgang FischerRegina SchliederAlexander NaveAndreas MeiselMartin EbingerIan Wellwood Source Type: research

Relationship between serum insulin-like growth factor 1 levels and ischaemic stroke: a systematic review and meta-analysis
Conclusion Higher serum IGF-1 was significantly correlated with a lower risk of ischaemic stroke. In view of the high degree of heterogeneity, it may need more studies to confirm the prognostic value of serum IGF-1 levels in ischaemic stroke and explore the sources of heterogeneity.
Source: BMJ Open - June 15, 2022 Category: General Medicine Authors: Li, Y., Yang, W., Li, J., Zhang, Y., Zhang, L., Chen, S., He, L., Zhang, Y. Tags: Open access, Neurology Source Type: research

Rationale and design of Short-Term EXenatide therapy in Acute ischaemic Stroke (STEXAS): a randomised, open-label, parallel-group study
Conclusions As GLP-1 analogues require elevated glucose levels to exert their insulin potentiating activity, the use of exenatide in the management of hyperglycaemia in AIS may reduce the incidence of hypoglycaemia, thereby conferring a benefit in morbidity and mortality for patients in the long term. Trial registration number ACTRN12614001189617.
Source: BMJ Open - February 24, 2016 Category: Journals (General) Authors: McGrath, R. T., Hocking, S. L., Priglinger, M., Day, S., Herkes, G. K., Krause, M., Fulcher, G. R. Tags: Open access, Neurology, Research methods, Diabetes and Endocrinology Protocol Source Type: research

Treatment of Hyperglycemia in Patients With Acute Stroke
To the Editor The multicenter Stroke Hyperglycemia Insulin Network Effort (SHINE) randomized clinical trial enrolled 1118 patients with acute ischemic stroke and hyperglycemia (923 with known diabetes) to test the effect of different blood glucose control strategies on neurological outcome. No difference in favorable functional outcome was found with intensive vs standard glucose control. We wish to highlight several issues.
Source: JAMA - December 10, 2019 Category: General Medicine Source Type: research

Diabetes Drug Drops CV Events After Stroke (CME/CE)
(MedPage Today) -- Findings suggest insulin resistance may be new target for secondary stroke prevention
Source: MedPage Today Meeting Coverage - February 17, 2016 Category: Journals (General) Source Type: news

Effect of Intensive vs Standard Treatment of Hyperglycemia on Functional Outcome in Stroke
This randomized clinical trial compares the effects of continuous intravenous vs subcutaneous sliding scale insulin for treatment of hyperglycemia during acute ischemic stroke on functional outcome in adult patients in the United States.
Source: JAMA - July 23, 2019 Category: General Medicine Source Type: research