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An antimicrobial metabolite n- hexadecenoic acid from marine sponge-associated bacteria < em > Bacillus subtilis < /em > effectively inhibited biofilm forming multidrug-resistant < em > P. aeruginosa < /em >
Biofouling. 2023 May-Jul;39(5):502-515. doi: 10.1080/08927014.2023.2232722. Epub 2023 Jul 24.ABSTRACTEffective drug candidates to obstruct the emergence of multidrug-resistant pathogens have become a major concern. A potent antimicrobial producer was isolated from a marine sponge designated as MSI38 and was identified as Bacillus subtilis by 16SrDNA sequencing. The active antimicrobial fraction was purified, and the metabolite was identified as n-hexadecanoic acid by spectroscopic analysis. The fish-borne pathogen Pseudomonas aeruginosa FP012 was found to be multidrug-resistant and poses a risk of disease to food handlers ...
Source: Biofouling - July 24, 2023 Category: Molecular Biology Authors: Arya Sajayan Amrudha Ravindran Joseph Selvin Prathiviraj Ragothaman George Seghal Kiran Source Type: research

Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen
This study aimed to evaluate the effects of long-term exposure to environmental CIP concentrations (1, 10, and 100 μg.L-1) in males and females of Rhamdia quelen. After 28 days of exposure, we collected the blood for the analysis of hematological and genotoxic biomarkers. Additionally, we measured 17 β-estradiol and 11 keto-testosterone levels. After the euthanasia, we collected the brain and the hypothalamus to analyze acetylcholinesterase (AChE) activity and neurotransmitters, respectively. The liver and gonads were assessed for biochemical, genotoxic, and histopathological biomarkers. At 100 μg.L-1 CIP, we observed g...
Source: Chemosphere - June 15, 2023 Category: Chemistry Authors: Lucicleide Ângelo Silva Jungles de Carvalho La ís Fernanda Oya-Silva Maiara Carolina Perussolo Gisele de Oliveira Guaita J úlio César Moreira Brito Allan Arnold Evans Maritana Mela Prodocimo Marta Margarete Cestari Tarcio Teodoro Bragah Helena Cristin Source Type: research

Mycobacterium marinum infection of the wrist
We report a patient with cutaneous Mycobacterium marinum infection with a non-pruritic erythematous plaque on his right wrist for three months. A history of exposure to contaminated freshwater two years prior was the only exposure that could be determined. Treatment with oral ciprofloxacin combined with clarithromycin produced a good outcome.PMID:37220290 | DOI:10.5070/D329260774
Source: Dermatol Online J - May 23, 2023 Category: Dermatology Authors: Chumsaeng Chumsaengsri Jirawan Khommee Papitchaya Urairerkkul Source Type: research

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