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< em > Elizabethkingia meningosepticum < /em > infections with varied presentations and different antimicrobial susceptibility - A case series
We report three sporadic infections by Elizabethkingia meningosepticum from Government Medical College Kozhikode in Kerala state, South India over a period of three years. Two cases were commenced in the community in immunocompromised children beyond the newborn period, but both recovered promptly. Another was a hospital-acquired meningitis in a newborn baby who developed neurologic sequelae. In contrast to widespread antimicrobial resistance exhibited by this pathogen, there was good susceptibility to commonly used antimicrobials such as ampicillin, cefotaxime, piperacillin, ciprofloxacin, and vancomycin. Whilst ß lactam...
Source: Tropical Doctor - June 8, 2023 Category: Tropical Medicine Authors: Chakkiyar Krishnan Madathil Govindaraj Geeta Methele Pangat Balakrishnan Shabina Thaliyil Veettil Rajesh Aishwarya Raj Vellani Thamunnu Ajithkumar Source Type: research

Proteus mirabilis isolated from untreated hospital wastewater, Ibadan, Southwestern Nigeria showed low-level resistance to fluoroquinolone and carried qnrD3 on Col3M plasmids
In this study, we investigated the determinants of resistance in three multidrug resistant strains of Proteus mirabilis isolated from untreated wastewater collected from three government owned hospitals in Ibadan, Nigeria. Despite showing low-level resistance to ciprofloxacin, whole genome sequencing revealed the transferable mechanism of quinolone resistance (TMQR) gene qnrD3 carried on Col3M plasmids in all the isolates. Core genome phylogenetic analysis showed the isolates are closely related differing from each other by ≤ 23 single nucleotide polymorphisms (SNP). Further, they shared the closest evolutionary relation...
Source: Environmental Science and Pollution Research International - February 3, 2023 Category: Environmental Health Authors: Adenike Omolola Ajayi-Odoko Ayantade Dayo Victor Ayansina Odion O Ikhimiukor Jochen A M üller Olawale Olufemi Adelowo Source Type: research

Current and developing therapies for the treatment of Multi Drug Resistant Tuberculosis (MDR-TB) in India.
Authors: Muniyandi M, Ramachandran R Abstract INTRODUCTION: India accounts for 25% of the global burden of MDR-TB. In 2016, the India's Revised National TB Control Programme reported a success rate of 46% among 19298 MDR-TB patients treated under the programme. This suboptimal treatment outcome warrants an urgent need for newer drugs and newer regimens in the treatment of MDR-TB. India requires new shorter, cheap, safe and effective anti-TB regimen to treat MDR-TB. Areas covered: We used different search strategies to obtain relevant literature from PubMed, on Indian experiences of developing therapies for the trea...
Source: Expert Opinion on Pharmacotherapy - August 9, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research