Filtered By:
Drug: Taxotere
Therapy: Gene Therapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 23 results found since Jan 2013.
Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel
Biomacromolecules. 2023 Feb 13. doi: 10.1021/acs.biomac.2c01329. Online ahead of print.ABSTRACTCationic glycopolymers stand out as gene delivery nanosystems due to their inherent biocompatibility and high binding affinity to the asialoglycoprotein receptor (ASGPR), a target receptor overexpressed in hepatocellular carcinoma (HCC) cells. However, their synthesis procedure remains laborious and complex, with problems of solubilization and the need for protection/deprotection steps. Here, a mini-library of well-defined poly(2-aminoethyl methacrylate hydrochloride-co-poly(2-lactobionamidoethyl methacrylate) (PAMA-co-PLAMA) gly...
Source: Biomacromolecules - February 13, 2023 Category: Biochemistry Authors: Daniela Santo Rosemeyre A Cordeiro Patr ícia V Mendonça Arm énio C Serra Jorge F J Coelho Henrique Faneca Source Type: research
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Novel treatments in BCG failure. Where do we stand today?
CONCLUSIONS: Results from ongoing trials will provide us useful information about many of the existing regimens and probably new drugs will soon be available for this group of patients.PMID:34472437
Source: Archivos Espanoles de Urologia - September 2, 2021 Category: Urology & Nephrology Authors: Charalampos Fragkoulis Ioannis Glykas Aristotelis Bamias Georgios Stathouros Georgios Papadopoulos Konstantinos Ntoumas Source Type: research
