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Drug: Herceptin
Therapy: Radiation Therapy
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Total 44 results found since Jan 2013.
Targeted systemic treatments and locoregional radiotherapy for breast cancer: Can we expect a benefit from the potentiation of local treatment?
Cancer Radiother. 2023 Aug 7:S1278-3218(23)00153-1. doi: 10.1016/j.canrad.2023.07.011. Online ahead of print.ABSTRACTBreast cancer is the first most common cancer worldwide, and radiation therapy has a major role to play in locoregional adjuvant treatment. In recent years, we have seen the emergence of adjuvant targeted systemic therapies improving the prognosis of patients at high risk of recurrence. Practices concerning combinations of targeted therapies and locoregional radiation therapy for non-metastatic breast cancers often remain heterogeneous due to the low level of evidence and lack of validated recommendations. T...
Source: Cancer Radiotherapie - August 9, 2023 Category: Cancer & Oncology Authors: A Camps Mal éa C Hennequin S Rivera Source Type: research
Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy: A systematic review and meta-analysis
CONCLUSION: Although there is some concern regarding a slight increase in pneumonitis when combining T-DM1 with postoperative RT, the safety profile of this combination was deemed acceptable for locoregional treatment in non-metastatic breast cancer. However, caution is advised when irradiating intracranial sites concurrently with T-DM1. There is a pressing need for international consensus guidelines regarding the safety considerations of combining T-DM1 and RT for breast cancer.PMID:37437610 | DOI:10.1016/j.radonc.2023.109805
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2023 Category: Radiology Authors: Viola Salvestrini Kyubo Kim Saverio Caini Sara Alkner Maria Ekholm Tanja Skytt ä Carlotta Becherini Charlotte E Coles Orit Kaidar-Person Birgitte Offersen Evandro de Azambuja Luca Visani Javier Cortes Nadia Harbeck Hope S Rugo Clare M Isacke Elisabetta M Source Type: research
Safety profile of trastuzumab-emtansine (T-DM1) with concurrent radiation therapy: a systematic review and meta-analysis
CONCLUSION: Although there is some concern regarding a slight increase in pneumonitis when combining T-DM1 with postoperative RT, the safety profile of this combination was deemed acceptable for locoregional treatment in non-metastatic breast cancer. However, caution is advised when irradiating intracranial sites concurrently with T-DM1. There is a pressing need for international consensus guidelines regarding the safety considerations of combining T-DM1 and RT for breast cancer.PMID:37437610 | DOI:10.1016/j.radonc.2023.109805
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 12, 2023 Category: Radiology Authors: Viola Salvestrini Kyubo Kim Saverio Caini Sara Alkner Maria Ekholm Tanja Skytt ä Carlotta Becherini Charlotte E Coles Orit Kaidar-Person Birgitte Offersen Evandro de Azambuja Luca Visani Javier Cortes Nadia Harbeck Hope S Rugo Clare M Isacke Elisabetta M Source Type: research
Late hepatic toxicity after breast cancer intensity-modulated radiotherapy using helicoidal tomotherapy
CONCLUSION: Delayed hepatotoxicity after multimodal non-metastatic breast cancer management including rotational IMRT was negligible. Consequently, the liver doesn't have to be considered like an organ-at-risk in the analysis of breast cancer radiotherapy but future prospectives studies are needed to confirm these findings.PMID:37179220 | DOI:10.1016/j.canrad.2023.03.001
Source: Cancer Radiotherapie - May 13, 2023 Category: Cancer & Oncology Authors: K Quintin P Loap A Fourquet Y Kirova Source Type: research
Radiotherapy and targeted therapy for the management of breast cancer: A review
Cancer Radiother. 2023 May 10:S1278-3218(23)00072-0. doi: 10.1016/j.canrad.2023.02.002. Online ahead of print.ABSTRACTThe purpose of this study was to review the current knowledge regarding combinations of the most commonly used targeted therapies or those under development for the management of breast cancer with radiation therapy. Several studies have shown that the combination of radiation therapy and tamoxifen increased the risk of radiation-induced lung toxicity; therefore, the two modalities are generally not given concurrently. The combination of HER2 inhibitors (trastuzumab, pertuzumab) and radiation therapy appear...
Source: Cancer Radiotherapie - May 12, 2023 Category: Cancer & Oncology Authors: A Beddok P Cottu A Fourquet Y Kirova Source Type: research
Safety and Tolerability of Metastasis-Directed Radiation Therapy in the Era of Evolving Systemic, Immune, and Targeted Therapies
CONCLUSIONS: Suggested approaches are described, using up-to-date literature, to aid clinicians in navigating the integration of newer targeted agents with hypofractionated palliative and/or ablative metastatic RT. Further prospective studies are required.PMID:36177487 | PMC:PMC9513086 | DOI:10.1016/j.adro.2022.101022
Source: Adv Data - September 30, 2022 Category: Epidemiology Authors: Elizabeth Guimond Chiaojung Jillian Tsai Ali Hosni Grainne O'Kane Jonathan Yang Aisling Barry Source Type: research
