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Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma
Biochem Biophys Res Commun. 2023 Feb 10;651:114-120. doi: 10.1016/j.bbrc.2023.02.021. Online ahead of print.ABSTRACTIn pharmacokinetics plasma protein binding (PPB) is a well-established parameter impacting drug disposition. The unbound fraction (fu) is arguably regarded the effective concentration at the target site. Pharmacology and toxicology, increasingly use in vitro models. The translation of in vitro concentrations to in vivo doses can be supported by toxicokinetic modelling, e.g. physiologically based toxicokinetic models (PBTK). PPB of a test substance is an input parameter for PBTK. We compared three methods to q...
Source: Biochemical and Biophysical Research communications - February 22, 2023 Category: Biochemistry Authors: Dunja Dimitrijevic Eric Fabian Dorothee Funk-Weyer Robert Landsiedel Source Type: research

Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer
Pharmaceutics. 2022 Jul 18;14(7):1486. doi: 10.3390/pharmaceutics14071486.ABSTRACTThe solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which is a potent chemotherapeutic, antioxidant, anti-inflammatory and P-gp inhibitor for enhancing bioavailability and to obtain synergistic anti-cancer effect against breast cancer. SNEDDS were developed using capmul MCM as oil, Tween 80 as surfactant and transcutol-HP as co-surfactant and optimized by central composite rotatable desig...
Source: Cell Research - July 27, 2022 Category: Cytology Authors: Nupur Shrivastava Ankit Parikh Rikeshwer Prasad Dewangan Largee Biswas Anita Kamra Verma Saurabh Mittal Javed Ali Sanjay Garg Sanjula Baboota Source Type: research

Encapsulated Peritoneal Sclerosis in an Adolescent With Kidney Transplant After Long-Term Peritoneal Dialysis
We present an 18-year-old female patient who was first diagnosed with renal failure at 8 years of age and who had 7 years of peritoneal dialysis and then hemodialysis before kidney transplant from a deceased donor. Before transplant, the patient developed encapsulated peritoneal sclerosis and was treated with tamoxifen and steroids. Three years after transplant, the patient presented with complaints of vomiting, abdominal pain, and abdominal distension and was again diagnosed with encapsulated peritoneal sclerosis. The patient required excretory paracentesis, pulse steroid treatment for 3 days, and treatment with methylpre...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 16, 2022 Category: Transplant Surgery Authors: Emre Levento ğlu Bahar B üyükkaragöz Ayd ın Dalgıç Kibriya Fidan O ğuz Söylemezoğlu Sevcan A Bakkalo ğlu Source Type: research