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Specialty: Environmental Health
Drug: Tamoxifen
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Total 33 results found since Jan 2013.
Comprehensive identification of gene expression fingerprints and biomarkers of sexual endocrine disruption in zebrafish embryo
Ecotoxicol Environ Saf. 2023 Jan 4;250:114514. doi: 10.1016/j.ecoenv.2023.114514. Online ahead of print.ABSTRACTEndocrine disruptors (EDs), capable of modulating the sex hormone system of an organism, can exert long-lasting negative effects on reproduction in both humans and the environment. For these reasons, the properties of EDs prevent a substance from being approved for marketing. However, regulatory testing to evaluate endocrine disruption is time-consuming, costly, and animal-intensive. Here, we combined sublethal zebrafish embryo assays with transcriptomics and proteomics for well-characterized endocrine disrupting...
Source: Ecotoxicology and Environmental Safety - January 6, 2023 Category: Environmental Health Authors: Steve U Ayobahan Julia Alvincz Hannes Reinwald Jannis Strompen Gabriela Salinas Christoph Sch äfers Elke Eilebrecht Sebastian Eilebrecht Source Type: research
4,4'-(9-Fluorenylidene)dianiline (BAFL) is antiestrogenic and has adverse effects on female development in CD-1 mice
Ecotoxicol Environ Saf. 2022 Oct 19;246:114202. doi: 10.1016/j.ecoenv.2022.114202. Online ahead of print.ABSTRACTMany phenolic compounds have been found to have endocrine disrupting activities, but their arylamine analogs, the phenolic hydroxyl groups substituted by aniline amino groups, have rarely been reported. 4,4'-(9-Fluorenylidene)dianiline (BAFL) is an arylamine analog of fluorene-9-bisphenol (BHPF) and BHPF has been reported to be a strong antiestrogen which could cause endometrial atrophy, ovarian damage and adverse pregnancy outcomes in animals. BAFL has been widely used as material to synthetize polymers, such a...
Source: Ecotoxicology and Environmental Safety - October 21, 2022 Category: Environmental Health Authors: Xiaojing Jia Ying Zhou Xingtai Mao Narma Huai Xuan Guo Zhaobin Zhang Source Type: research
Antiestrogenic property of 9,9-bis4-(2-hydroxyethoxy)phenylfluorene (BPEF) and its effects on female development in CD-1 mice
Ecotoxicol Environ Saf. 2022 Jul 22;242:113906. doi: 10.1016/j.ecoenv.2022.113906. Online ahead of print.ABSTRACTIdentifying chemicals with endocrine disrupting properties linked to disease outcomes is a key concern, as stated in the WHO-UNEP 2012 report on endocrine-disrupting chemicals. The chemical 9,9-bis[4-(2-hydroxyethoxy)phenyl]fluorene (BPEF) is widely and increasingly applied in synthesizing fluorene-based cardo polymers with superior optical, thermal and mechanical properties for various uses. However, little toxicological information is available regarding its safety. Here, we studied the endocrine disrupting pr...
Source: Ecotoxicology and Environmental Safety - July 25, 2022 Category: Environmental Health Authors: Xiaojing Jia Xingtai Mao Ying Zhou Xuan Guo Narma Huai Ying Hu Libei Sun Jilong Guo Zhaobin Zhang Source Type: research
Tricresyl phosphate inhibits fertilization in Japanese medaka (Oryzias latipes): Emphasizing metabolic toxicity
Environ Pollut. 2022 Jan 8;297:118809. doi: 10.1016/j.envpol.2022.118809. Online ahead of print.ABSTRACTAs tricresyl phosphate (TCrP) is commonly found in global water sources, its potential reproductive toxicity to fish is of increasing concern. Japanese medaka larvae were exposed to TCrP at 657.9, 1,511, and 4042 ng/L for 100 days. We identified significant fertilization inhibition (6.9%-12.8%) in all exposure groups. Intersex was significantly induced at 4042 ng/L, with an incidence of 22.0%. TCrP exposure also caused dilation of the efferent duct in the testes with maximum duct widths of 83.3, 93.2, and 149.7 μm in th...
Source: Environmental Pollution - January 12, 2022 Category: Environmental Health Authors: Ruichao Chen Jianwu He Yu Li Lihui An Jianying Hu Source Type: research
Photolytic Fate of (E)- and (Z)-Endoxifen in Water and Treated Wastewater Exposed to Sunlight
This study elucidated the fate and susceptibility of (E)- and (Z)-endoxifen (2 μg mL-1, 1:1 weight ratio between the two easily interchangeable isomers) in wastewater and receiving surface water to sunlight. Phototransformation by-products (PBPs) and their toxicity were determined. Sunlight reduced at least 83% of endoxifen concentration in wastewater samples, whereas in surface water samples, 60% of endoxifen was photodegraded after 180 min of the irradiation. In ultrapure water samples spiked with endoxifen, PBPs were mainly generated via con-rotatory 6π-photocyclization, followed by oxidative aromatization. These PBPs...
Source: Environmental Research - April 6, 2021 Category: Environmental Health Authors: Marina Ari ño Martin Jayaraman Sivaguru John McEvoy Prinpida Sonthiphand Eakalak Khan Source Type: research
Anticancer drugs in the aquatic ecosystem: Environmental occurrence, ecotoxicological effect and risk assessment
Environ Int. 2021 Apr 1;153:106543. doi: 10.1016/j.envint.2021.106543. Online ahead of print.ABSTRACTAnticancer drugs are a group of therapeutic agents used to enhance cell death in targeted cell types of neoplasia. Because of frequent use and eventual discharge, they have been often detected in wastewater from pharmaceutical factories and hospitals, domestic wastewater, and surface waters. The occurrence of these drugs in aquatic ecosystems and their effects on aquatic organisms have been poorly characterized. This review focuses on the global occurrence of major classes of anticancer drugs in water and sediments of fresh...
Source: Environment International - April 4, 2021 Category: Environmental Health Authors: Dan Li Hongxing Chen Hongsong Liu Daniel Schlenk Jingli Mu Silvia Lacorte Guang-Guo Ying Lingtian Xie Source Type: research
Embryotoxicity of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae
This study aimed to evaluate the putative toxicity of five cytostatics to fathead minnow (Pimephales promelas) larvae: tamoxifen, capecitabine, methotrexate, cyclophosphamide, and ifosfamide. Eggs collected post-fertilization were exposed for 6 days to a range of concentrations, including one above environmental level. At all environmental concentrations, no significant difference in mortality, hatching time, length, heart rate, and presence of malformations were found. Altogether, these cytostatics do not seem embryotoxic to fish. Although, an increased proportion of complete swim bladder were found after ifosfamide's exp...
Source: Bulletin of Environmental Contamination and Toxicology - March 13, 2021 Category: Environmental Health Authors: M Lefebvre-Raine N Paquet G Triffault-Bouchet V S Langlois Source Type: research
The impact of xenoestrogens on effectiveness of treatment for hormone-dependent breast cancer - current state of knowledge and perspectives for research
CONCLUSIONS: Confirmation in clinical trials of the results obtained in vitro and in vivo tests, would enable the creation of specific recommendations for patients undergoing breast cancer treatment, especially hormone therapy. An area requiring further research is the analysis of the effects of xenoestrogens other than phytoestrogens, e.g. metalloestrogens, on the effects of drugs used in the treatment of breast cancer.PMID:33356056 | DOI:10.26444/aaem/124165
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 28, 2020 Category: Environmental Health Authors: Kamila Boszkiewicz Ewa Sawicka Agnieszka Piwowar Source Type: research
