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Drug: Tamoxifen
Nutrition: Soy isoflavones
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Total 42 results found since Jan 2013.
Suppression of breast cancer: modulation of estrogen receptor and downregulation of gene expression using natural products
Nat Prod Res. 2023 Jul 10:1-10. doi: 10.1080/14786419.2023.2232926. Online ahead of print.ABSTRACTThe main cause of cancer death among women is breast cancer. The most common type of breast cancer is the estrogen receptor positive breast cancer. Discovery of estrogen receptor provided a highly effective target for treatment of hormone-dependent breast cancer. Selective estrogen receptor inhibitors are useful for halting the growth of breast cancer cells and inducing apoptosis. Tamoxifen, a popular selective estrogen receptor modulator, can treat breast cancer but also has unfavourable side effects due to its estrogenic act...
Source: Cell Research - July 10, 2023 Category: Cytology Authors: Haidy Ahmed Alyaa Abdelraheem Mona Salem Martha Sabry Nada Fekry Fatma Mohamed Ahmed Saber Diletta Piatti Miral Sabry Omar Sabry Giovanni Caprioli Source Type: research
Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma
Biochem Biophys Res Commun. 2023 Feb 10;651:114-120. doi: 10.1016/j.bbrc.2023.02.021. Online ahead of print.ABSTRACTIn pharmacokinetics plasma protein binding (PPB) is a well-established parameter impacting drug disposition. The unbound fraction (fu) is arguably regarded the effective concentration at the target site. Pharmacology and toxicology, increasingly use in vitro models. The translation of in vitro concentrations to in vivo doses can be supported by toxicokinetic modelling, e.g. physiologically based toxicokinetic models (PBTK). PPB of a test substance is an input parameter for PBTK. We compared three methods to q...
Source: Biochemical and Biophysical Research communications - February 22, 2023 Category: Biochemistry Authors: Dunja Dimitrijevic Eric Fabian Dorothee Funk-Weyer Robert Landsiedel Source Type: research
Design, synthesis and anti-breast cancer activity of novel fluorinated 7-O-modified genistein derivatives
CONCLUSION: The activities against breast cancer of genistein were enhanced by introducing 7-alkoxyl group and fluorine atom into the B-ring. Therefore, these compounds may be potential candidates for treating breast cancer.PMID:35674304 | DOI:10.2174/1573406418666220607140651
Source: Medicinal Chemistry - June 8, 2022 Category: Chemistry Authors: Zhifang Yang Yi Liu Zhuo Liu Qinfang Xu Shun Liu Kailin Jiang Yuanlong Shi Wenyu Xu Zehua Yang Pengbing Mi Yijun Xiang Xu Yao Xing Zheng Source Type: research
Synthesis and Bio-evaluation of 2-Alkyl Substituted Fluorinated Genistein Analogues Against Breast Cancer
CONCLUSION: Most of the newly synthesized compounds could highly selectively inhibit breast cancer cell lines. The experimental results indicate that the synthesized analogs may also have obvious selective inhibitory effects on other malignant proliferation cancer cells.PMID:34463229 | DOI:10.2174/1573406417666210830114715
Source: Medicinal Chemistry - August 31, 2021 Category: Chemistry Authors: Yingli Zhu Fan Zheng Can Xiao Xiaohe Liu Xu Yao Wenbin Zeng Source Type: research
